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Clinical research

Edited by Holger Cramer, Jianping Liu and Karen Pilkington

This section covers research reporting clinical applications of interventions or resources in the complementary medicine field, including the evaluation of the efficacy and safety of the therapies, clinical trials and systematic reviews/meta-analysis.

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  1. Content type: Research article

    In the author’s earlier in vitro investigation, a combination of 0.25 mg/ml green tea and 7.82 mg/ml Salvadora persica L. aqueous extracts was found to exhibit significant synergistic anti-bacterial and anti-adhe...

    Authors: Hayder Raad Abdulbaqi, Wan Harun Himratul-Aznita and Nor Adinar Baharuddin

    Citation: BMC Complementary and Alternative Medicine 2016 16:493

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  2. Content type: Research article

    Manual muscle testing (MMT) is a non-invasive assessment tool used by a variety of health care providers to evaluate neuromusculoskeletal integrity, and muscular strength in particular. In one form of MMT call...

    Authors: Anne M. Jensen, Richard J. Stevens and Amanda J. Burls

    Citation: BMC Complementary and Alternative Medicine 2016 16:492

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  3. Content type: Study protocol

    Coronary artery bypass graft surgery (CABG) is an effective and widespread coronary revascularisation technique, nevertheless there are a number of long-term postoperative complications from which patients can...

    Authors: Gert Roncada

    Citation: BMC Complementary and Alternative Medicine 2016 16:482

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  4. Content type: Research article

    Hashimoto’s thyroiditis is an autoimmune disorder and the most common cause of hypothyroidism. The use of Nigella sativa, a potent herbal medicine, continues to increase worldwide as an alternative treatment o...

    Authors: Mahdieh Abbasalizad Farhangi, Parvin Dehghan, Siroos Tajmiri and Mehran Mesgari Abbasi

    Citation: BMC Complementary and Alternative Medicine 2016 16:471

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  5. Content type: Research article

    The effect and safety of catgut implantation at acupoints o treat allergic rhinitis (ICD-10 code J30.4) remain controversial. Here, we used a sham catgut implantation group to determine whether catgut implanta...

    Authors: Xinrong Li, Yang Liu, Qinxiu Zhang, Nan Xiang, Miao He, Juan Zhong, Qing Chen and Xiaopei Wang

    Citation: BMC Complementary and Alternative Medicine 2016 16:454

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  6. Content type: Research article

    The theory of traditional Chinese medicine (TCM) constitution involves genetic characteristics, psychological factors, organ functions, and many other aspects. Studies have shown that TCM constitution is assoc...

    Authors: Yi Liu, Ting Pan, Wenjing Zou, Ye Sun, Yun Cai, Rui Wang, Pingping Han, Zhe Zhang, Qunying He and Feng Ye

    Citation: BMC Complementary and Alternative Medicine 2016 16:451

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  7. Content type: Research article

    Postoperative nausea and vomiting (PONV) is one of the most common postoperative complications of general anesthesia in pediatrics. Aromatherapy has been shown to be effective in treating PONV in adults. Given...

    Authors: Mathew B. Kiberd, Suzanne K. Clarke, Jill Chorney, Brandon d’Eon and Stuart Wright

    Citation: BMC Complementary and Alternative Medicine 2016 16:450

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  8. Content type: Research article

    Danlou tablets, a patented Chinese Medicine, have been long approved for the treatment of ischemic heart disease in China. While numerous empirical observations suggested Danlou tablets could decrease frequenc...

    Authors: Shuai Mao, Lei Wang, Wenwei Ouyang, Yuanshen Zhou, Jianyong Qi, Liheng Guo, Minzhou Zhang and Aleksander Hinek

    Citation: BMC Complementary and Alternative Medicine 2016 16:447

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  9. Content type: Study protocol

    Acupuncture is beneficial for controlling chemotherapy-induced nausea and vomiting (CINV). However, the effect of different acupoint combinations on controlling CINV remains unknown. This study aims to compare...

    Authors: Lili Gao, Bo Chen, Qiwen Zhang, Tianyi Zhao, Bo Li, Tao Sha, Jinxin Zou, Yongming Guo, Xingfang Pan and Yi Guo

    Citation: BMC Complementary and Alternative Medicine 2016 16:441

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  10. Content type: Study protocol

    Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) affects many adult men worldwide. The currently available therapies offer little or no proven benefit for CP/CPPS. We designed this study to assess th...

    Authors: Zongshi Qin, Zhiwei Zang, Jiani Wu, Jing Zhou and Zhishun Liu

    Citation: BMC Complementary and Alternative Medicine 2016 16:440

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  11. Content type: Research article

    Allergic rhinitis is regarded as an imbalanced Th1/Th2 cell-mediated response. The present study used microarray analysis to compare gene expression levels between allergic rhinitis patients before and after a...

    Authors: Horng-Sheng Shiue, Yun-Shien Lee, Chi-Neu Tsai and Hen-Hong Chang

    Citation: BMC Complementary and Alternative Medicine 2016 16:436

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  12. Content type: Study protocol

    Caregiving can be stressful, potentially creating physical and psychological strain. Substantial evidence has shown that family caregivers suffer from significant health problems arising from the demands of ca...

    Authors: Agnes Tiwari, Lixing Lao, Amy Xiao-Min Wang, Denise Shuk Ting Cheung, Mike Ka Pui So, Doris Sau Fung Yu, Terry Yat Sang Lum, Helina Yin King Yuk Fung, Jerry Wing Fai Yeung and Zhang-Jin Zhang

    Citation: BMC Complementary and Alternative Medicine 2016 16:424

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  13. Content type: Study protocol

    Irritable bowel syndrome (IBS) is a worldwide disease with high morbidity. The effect of current treatment with Western medicine is not satisfactory. Although moxibustion treatment is widely used for gastroint...

    Authors: Chunhui Bao, Jingzhi Zhang, Jinmei Liu, Huirong Liu, Luyi Wu, Yin Shi, Jing Li, Zhihai Hu, Yongzheng Dong, Siyao Wang, Xiaoqing Zeng and Huangan Wu

    Citation: BMC Complementary and Alternative Medicine 2016 16:408

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  14. Content type: Study protocol

    Virgin olive oil, a recognized healthy food, cannot be consumed in great quantities. We aim to assess in humans whether an optimized virgin olive oil with high phenolic content (OVOO, 429 mg/Kg) and a function...

    Authors: Sara Biel, Maria-Dolores Mesa, Rafael de la Torre, Juan-Antonio Espejo, Jose-Ramón Fernández-Navarro, Montserrat Fitó, Estefanía Sánchez-Rodriguez, Carmen Rosa, Rosa Marchal, Juan de Dios Alche, Manuela Expósito, Manuel Brenes, Beatriz Gandul, Miguel Angel Calleja and María-Isabel Covas

    Citation: BMC Complementary and Alternative Medicine 2016 16:404

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  15. Content type: Research article

    In Japanese Kampo medical practice, suidoku (fluid disturbance) is one of the most important concepts for selecting the proper medication. Suidoku is an excessive or uneven distribution of fluid that is indica...

    Authors: Aya Murakami, Daisuke Kobayashi, Toshio Kubota, Niina Zukeyama, Haru Mukae, Norihiro Furusyo, Mosaburo Kainuma and Takao Shimazoe

    Citation: BMC Complementary and Alternative Medicine 2016 16:405

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  16. Content type: Research article

    Blood-stasis syndrome (BSS) is one of the Traditional Chinese medicine (TCM) syndrome differentiations that are commonly seen in stroke and ischemic heart diseases; however, the BSS differentiation criterion i...

    Authors: Jiangquan Liao, Yongmei Liu and Jie Wang

    Citation: BMC Complementary and Alternative Medicine 2016 16:371

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    The Erratum to this article has been published in BMC Complementary and Alternative Medicine 2016 16:458

  17. Content type: Research article

    The primary objective of this study was to assess whether Zhengtian Capsule was non-inferior to flunarizine in efficacy and safety profile for prevention of migraine in adults.

    Authors: Kegang Cao, Fang Han, Anji Lin, Wenming Yang, Jianjun Zhao, Hui Zhang, Yanbing Ding, Wei Xie, Yinping Xu, Tingmin Yu, Xinzhi Wang, Xiaosu Yang, Jiying Zhou, Qun Hou, Lihua Yu and Ying Gao

    Citation: BMC Complementary and Alternative Medicine 2016 16:356

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  18. Content type: Research article

    Cerebral infarction frequently leads to mild cognitive impairment (MCI). Prompt management of MCI can prevent vascular dementia and improve patient outcome. This single center randomized controlled trial aims ...

    Authors: Shuhua Wang, Hongling Yang, Jie Zhang, Bin Zhang, Tao Liu, Lu Gan and Jiangang Zheng

    Citation: BMC Complementary and Alternative Medicine 2016 16:361

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  19. Content type: Research article

    Chinese traditional “eye exercises of acupoints” have been advocated as a compulsory measure to reduce visual symptoms, as well as to retard the development of refractive error, among Chinese students for deca...

    Authors: Zhong Lin, Balamurali Vasudevan, Su Jie Fang, Vishal Jhanji, Guang Yun Mao, Wei Han, Tie Ying Gao, Kenneth J. Ciuffreda and Yuan Bo Liang

    Citation: BMC Complementary and Alternative Medicine 2016 16:349

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