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Clinical research

Edited by Holger Cramer, Jianping Liu and Karen Pilkington

This section covers research reporting clinical applications of interventions or resources in the complementary medicine field, including the evaluation of the efficacy and safety of the therapies, clinical trials and systematic reviews/meta-analysis.

Page 4 of 6

  1. Content type: Case report

    In Taiwan, there is a good universal healthcare system to the patients; however, the majority of Taiwanese seek the complementary and alternative medicine when they are injured or ill. The traditional Chinese ...

    Authors: Chiu-Liang Chen, Shin-Lin Chiu, Chiao-Lee Chu and Shou-Jen Lan

    Citation: BMC Complementary and Alternative Medicine 2015 15:98

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  2. Content type: Research article

    Many smokers are unable to access effective behavioral smoking cessation therapies due to location, financial limitations, schedule, transportation issues or other reasons. We report results from a prospective...

    Authors: James M Davis, Alison R Manley, Simon B Goldberg, Kristin A Stankevitz and Stevens S Smith

    Citation: BMC Complementary and Alternative Medicine 2015 15:95

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  3. Content type: Research article

    One of the most common symptoms observed in patients with dementia is agitation, and several non-pharmacological treatments have been used to control this symptom. However, because of limitations in research d...

    Authors: Man-Hua Yang, Li-Chan Lin, Shiao-Chi Wu, Jen-Hwey Chiu, Pei-Ning Wang and Jaung-Geng Lin

    Citation: BMC Complementary and Alternative Medicine 2015 15:93

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  4. Content type: Research article

    Complementary therapies (CT), such as relaxation technique, massage, guided imagery, and accupuncture have shown to benefit patients undergoing surgery. The aim of this study was to determine the feasibility o...

    Authors: Margaret M Hansen

    Citation: BMC Complementary and Alternative Medicine 2015 15:92

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  5. Content type: Research article

    Previous research suggests benefits of yoga in reducing depression and anxiety. However, common concerns in reviews of the research include lack of detail, rationale and consistency of approach of intervention...

    Authors: Michael de Manincor, Alan Bensoussan, Caroline Smith, Paul Fahey and Suzanne Bourchier

    Citation: BMC Complementary and Alternative Medicine 2015 15:85

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  6. Content type: Research article

    Short-term vasodilatation in the pain area after dry needling (DN) of active trigger points (TrPs) was recorded in several cases of sciatica. Moreover, the presence of TrPs in sciatica patients secondary to pr...

    Authors: Elżbieta Skorupska, Michał Rychlik and Włodzimierz Samborski

    Citation: BMC Complementary and Alternative Medicine 2015 15:72

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  7. Content type: Research article

    An emerging paradigm suggests children with autism display a unique pattern of environmental, genetic, and epigenetic triggers that make them susceptible to developing dysfunctional heavy metal and chemical de...

    Authors: Scott Faber, Gregory M Zinn, Andrew Boggess, Timothy Fahrenholz, John C Kern II and HM Skip Kingston

    Citation: BMC Complementary and Alternative Medicine 2015 15:71

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  8. Content type: Research article

    Metabolic syndrome (MetS) comprises a spectrum of clinical phenotypes in which dyslipidemia, dysglycemia and hypertension are clustered and where all share a high level of oxidative stress and an increased ris...

    Authors: Veronique Verhoeven, Anastasia Van der Auwera, Luc Van Gaal, Roy Remmen, Sandra Apers, Michel Stalpaert, Johan Wens and Nina Hermans

    Citation: BMC Complementary and Alternative Medicine 2015 15:52

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  9. Content type: Research article

    Biobanks are more important in medical area because they can give researchers data for demonstrating and validating their research. In this study, we developed a biobank called the Korea Constitutional Multice...

    Authors: Hee-Jeong Jin, Younghwa Baek, Ho-Seok Kim, Jonghyang Ryu and Siwoo Lee

    Citation: BMC Complementary and Alternative Medicine 2015 15:46

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  10. Content type: Research article

    The rates of muscle aches, sprains, and inflammation are significantly increased during pregnancy. However, women are afraid to use systemic analgesics due to perceptions of fetal risks. Thus, topical products...

    Authors: Abdulaziz MS Alsaad, Colleen Fox and Gideon Koren

    Citation: BMC Complementary and Alternative Medicine 2015 15:40

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  11. Content type: Research article

    Xuesaitong Injection (XST) is one of the most commonly used medicines for treating acute cerebral infarction (ACI) in China. However, compared to the conventional therapy with western medicines (WM), the effec...

    Authors: Xiaomeng Zhang, Jiarui Wu and Bing Zhang

    Citation: BMC Complementary and Alternative Medicine 2015 15:36

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  12. Content type: Study protocol

    Balance dysfunction after stroke limits patients’ general function and participation in daily life. Previous researches have suggested that Tai Chi exercise could offer a positive improvement in older individu...

    Authors: Jing Tao, Ting Rao, Lili Lin, Wei Liu, Zhenkai Wu, Guohua Zheng, Yusheng Su, Jia Huang, Zhengkun Lin, Jinsong Wu, Yunhua Fang and Lidian Chen

    Citation: BMC Complementary and Alternative Medicine 2015 15:31

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  13. Content type: Research article

    Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are highly prevalent and associated with a large symptom burden, that is compounded in a dual HF-COPD diagnosis. Yoga has potential benefit f...

    Authors: Lucy Selman, Kelly McDermott, DorAnne Donesky, Tracie Citron and Jill Howie-Esquivel

    Citation: BMC Complementary and Alternative Medicine 2015 15:21

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  14. Content type: Research article

    Tai Chi is the Chinese traditional medicine exercise for mind-body health. The objective of this study is to investigate the effect of Tai Chi Chuan (TCC) exercise on the proliferative and cytolytic/tumoricida...

    Authors: Jing Liu, Peijie Chen, Ru Wang, Yonghong Yuan, Xueqiang Wang and Chunying Li

    Citation: BMC Complementary and Alternative Medicine 2015 15:3

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  15. Content type: Research article

    Fatigue is an important problem in paediatric cancer patients and yoga may be an effective intervention. The primary objective was to determine the feasibility of individualized yoga for hospitalized children ...

    Authors: Caroline Diorio, Tal Schechter, Michelle Lee, Cathy O’Sullivan, Tanya Hesser, Deborah Tomlinson, Janine Piscione, Christine Armstrong, George Tomlinson and Lillian Sung

    Citation: BMC Complementary and Alternative Medicine 2015 15:2

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  16. Content type: Research article

    Andrographis paniculata (andrographis) is one of the herbal products that are widely used for various indications. Hypersensitivity reactions have been reported among subjects receiving Andrographis paniculata i...

    Authors: Wimon Suwankesawong, Surasak Saokaew, Unchalee Permsuwan and Nathorn Chaiyakunapruk

    Citation: BMC Complementary and Alternative Medicine 2014 14:515

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  17. Content type: Research article

    Polycystic ovary syndrome (PCOS) is a prevalent, complex endocrine disorder characterised by polycystic ovaries, chronic anovulation and hyperandrogenism leading to symptoms of irregular menstrual cycles, hirs...

    Authors: Susan Arentz, Jason Anthony Abbott, Caroline Anne Smith and Alan Bensoussan

    Citation: BMC Complementary and Alternative Medicine 2014 14:511

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  18. Content type: Research article

    Moxibustion is one of the most commonly used therapies in acupuncture practice, and is demonstrated to be beneficial for patients with diarrhea from irritable bowel syndrome (D-IBS). But its mechanism remains ...

    Authors: Yi Zhu, Zhiyuan Wu, Xiaopeng Ma, Huirong Liu, Chunhui Bao, Ling Yang, Yunhua Cui, Cili Zhou, Xiaomei Wang, Yuemin Wang, Zhongwei Zhang, Huan Zhang, Haipeng Jia and Huangan Wu

    Citation: BMC Complementary and Alternative Medicine 2014 14:500

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  19. Content type: Research article

    Many studies show an effectiveness of hypnotic analgesia. It has been discussed whether the analgesic effect is mainly caused by the relaxation that is concomitant to hypnosis. This study was designed to evalu...

    Authors: Sybille Kramer, Rolf Zims, Michael Simang, Linda Rüger and Dominik Irnich

    Citation: BMC Complementary and Alternative Medicine 2014 14:496

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  20. Content type: Research article

    Pain and anxiety occurring from cardiovascular disease are associated with long-term health risks. Integrative medicine (IM) therapies reduce pain and anxiety in small samples of hospitalized cardiovascular pa...

    Authors: Jill R Johnson, Daniel J Crespin, Kristen H Griffin, Michael D Finch, Rachael L Rivard, Courtney J Baechler and Jeffery A Dusek

    Citation: BMC Complementary and Alternative Medicine 2014 14:486

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  21. Content type: Research article

    Humans are exposed to toxins which accumulate in the body, and are detoxified primarily in the liver. Studies have shown that cruciferous vegetables (such as radishes) may be beneficial to health by aiding det...

    Authors: Malkanthi Evans, Elaine Paterson and David M Barnes

    Citation: BMC Complementary and Alternative Medicine 2014 14:475

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  22. Content type: Research article

    Stress places a metabolic burden on homeostasis and is linked to heightened sympathetic activity, increased energy expenditure and pathology. The yogic state is a hypometabolic state that corresponds with mind...

    Authors: Anupama Tyagi, Marc Cohen, John Reece and Shirley Telles

    Citation: BMC Complementary and Alternative Medicine 2014 14:445

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  23. Content type: Research article

    ‘Kneipp Therapy’ (KT) is a form of Complementary and Alternative Medicine (CAM) that includes a combination of hydrotherapy, herbal medicine, mind-body medicine, physical activities, and healthy eating. Since ...

    Authors: Miriam Ortiz, Eva Soom Ammann, Corina Salis Gross, Katharina Schnabel, Torsten Walbaum, Sylvia Binting, Herbert Felix Fischer, Michael Teut, Jan Kottner, Ralf Suhr and Benno Brinkhaus

    Citation: BMC Complementary and Alternative Medicine 2014 14:443

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  24. Content type: Research article

    Sensory isolation in a flotation tank is a method known for inducing deep relaxation and subsequent positive health effects for patients suffering from e.g. stress or muscle tensions pains. Very few studies ha...

    Authors: Anette Kjellgren and Jessica Westman

    Citation: BMC Complementary and Alternative Medicine 2014 14:417

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  25. Content type: Study protocol

    Negative affective states such as anxiety, depression and stress are significant risk factors for cardiovascular disease, particularly in cardiac and post-cardiac rehabilitation populations.

    Authors: Alan Yeung, Hosen Kiat, A Robert Denniss, Birinder S Cheema, Alan Bensoussan, Bianca Machliss, Ben Colagiuri and Dennis Chang

    Citation: BMC Complementary and Alternative Medicine 2014 14:411

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  26. Content type: Research article

    Musculoskeletal disorders, stress and performance anxiety are common in musicians. Therefore, some use the Alexander Technique (AT), a psycho-physical method that helps to release unnecessary muscle tension an...

    Authors: Sabine D Klein, Claudine Bayard and Ursula Wolf

    Citation: BMC Complementary and Alternative Medicine 2014 14:414

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  27. Content type: Research article

    The progressive nature of glaucoma and its growing incidence make its therapy an important target for research. The role of oxidative damage in the pathogenesis of glaucoma makes antioxidants such as saffron e...

    Authors: Mohammad Hossein Jabbarpoor Bonyadi, Shahin Yazdani and Saeed Saadat

    Citation: BMC Complementary and Alternative Medicine 2014 14:399

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  28. Content type: Research article

    Traditional Chinese medicine (TCM) is the most commonly used alternative therapy in children with asthma, especially in the Chinese community. This study aimed to investigate the effects of the government-spon...

    Authors: Yu-Chiang Hung, I-Ling Hung, Mao-Feng Sun, Chih-Hsin Muo, Bei-Yu Wu, Ying-Jung Tseng and Wen-Long Hu

    Citation: BMC Complementary and Alternative Medicine 2014 14:389

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  29. Content type: Study protocol

    About six percent of pregnant women suffer from severe fear of childbirth. These women are at increased risk of obstetric labour and delivery interventions and pre- and postpartum complications, e.g., preterm ...

    Authors: Gert A Klabbers, Klaas Wijma, K Marieke Paarlberg, Wilco HM Emons and Ad JJM Vingerhoets

    Citation: BMC Complementary and Alternative Medicine 2014 14:385

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  30. Content type: Research article

    Therapy-induced mucositis and dysphagia puts head and neck (H&N) cancer patients at increased risk for developing cachexia. Omega-3 fatty acids (n-3 FA) have been suggested to protect against cachexia. We aimed t...

    Authors: Lies Pottel, Michelle Lycke, Tom Boterberg, Hans Pottel, Laurence Goethals, Fréderic Duprez, Alex Maes, Stefan Goemaere, Sylvie Rottey, Imogen Foubert and Philip R Debruyne

    Citation: BMC Complementary and Alternative Medicine 2014 14:382

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  31. Content type: Study protocol

    Patients with schizophrenia are characterized by high prevalence rates and chronicity that often leads to long-term institutionalization. Under the traditional medical model, treatment usually emphasizes the m...

    Authors: Rainbow Tin Hung Ho, Adrian Ho Yin Wan, Friendly So Wah Au-Yeung, Phyllis Hau Yan Lo, Pantha Joey Chung Yue Siu, Cathy Pui Ki Wong, Winnie Yuen Han Ng, Irene Kit Man Cheung, Siu Man Ng, Cecilia Lai Wan Chan and Eric Yu Hai Chen

    Citation: BMC Complementary and Alternative Medicine 2014 14:364

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  32. Content type: Research article

    Among underserved, largely minority women who were breast cancer survivors, this pilot project was designed to evaluate the quality of life outcomes of a 20 week Contemplative Self-Healing Program.

    Authors: Mary E Charlson, Joseph Loizzo, Alyson Moadel, Miles Neale, Chayim Newman, Erin Olivo, Emily Wolf and Janey C Peterson

    Citation: BMC Complementary and Alternative Medicine 2014 14:349

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  33. Content type: Research article

    Postprandial hyperglycemia is a known risk factor for the development of several health disorders including type 2 diabetes, obesity, oxidative stress, and cardiovascular diseases. One encouraging approach for...

    Authors: Vickram Beejmohun, Marie Peytavy-Izard, Cyril Mignon, Delphine Muscente-Paque, Xavier Deplanque, Christophe Ripoll and Nicolas Chapal

    Citation: BMC Complementary and Alternative Medicine 2014 14:351

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  34. Content type: Study protocol

    Knee osteoarthritis (OA) causes pain and long-term disability with annual healthcare costs exceeding $185 billion in the United States. Few medical remedies effectively influence the course of the disease. Fin...

    Authors: Chenchen Wang, Maura D Iversen, Timothy McAlindon, William F Harvey, John B Wong, Roger A Fielding, Jeffrey B Driban, Lori Lyn Price, Ramel Rones, Tressa Gamache and Christopher H Schmid

    Citation: BMC Complementary and Alternative Medicine 2014 14:333

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  35. Content type: Erratum

    Authors: John E Lewis, Angelica B Melillo, Eduard Tiozzo, Lawrence Chen, Susanna Leonard, Mark Howell, Janelle Diaz, Kathy Gonzalez, Judi M Woolger, Janet Konefal, Elaine Paterson and David Barnes

    Citation: BMC Complementary and Alternative Medicine 2014 14:332

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    The original article was published in BMC Complementary and Alternative Medicine 2014 14:43

  36. Content type: Research article

    Acupuncture has been shown to reduce pain, and acupuncture-induced sensation may be important for this analgesia. In addition, cognitive coping strategies can influence sensory perception. However, the role of...

    Authors: Jeungchan Lee, Vitaly Napadow and Kyungmo Park

    Citation: BMC Complementary and Alternative Medicine 2014 14:324

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  37. Content type: Research article

    Electroacupuncture (EA) is a traditional Chinese medicine treatment guided by meridian theory. As it gradually gains more worldwide acceptance, a clarification of its mechanisms is extremely urgent. We observe...

    Authors: Shu-Xia Zheng, Xiao-Hua Pan, Jin-Sen Xu, Chun-Ying Xiu, Ya-Qin Dong and Xiaoxiang Zhu

    Citation: BMC Complementary and Alternative Medicine 2014 14:323

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  38. Content type: Research article

    The purpose of present study was to examine biological and psychological characteristics of people according to the Sasang typology, which is popular in Korea. We evaluated the Sasang Personality Questionnaire...

    Authors: Soo Jin Lee, Soo Hyun Park, C Robert Cloninger, Yun Hee Kim, Minwoo Hwang and Han Chae

    Citation: BMC Complementary and Alternative Medicine 2014 14:315

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  39. Content type: Research article

    The aging process involves a decline in immune functioning that renders elderly people more vulnerable to disease. In residential programs for the aged, it is vital to diminish their risk of disease, promote t...

    Authors: Abilio Reig-Ferrer, Rosario Ferrer-Cascales, Ana Santos-Ruiz, Adolfo Campos-Ferrer, Alvaro Prieto-Seva, Irene Velasco-Ruiz, Maria Dolores Fernandez-Pascual and Natalia Albaladejo-Blazquez

    Citation: BMC Complementary and Alternative Medicine 2014 14:311

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  40. Content type: Research article

    The utility of acupuncture in managing osteoarthritis symptoms is uncertain. Trial results are conflicting and previous systematic reviews may have overestimated the benefits of acupuncture.

    Authors: Taru Manyanga, Maria Froese, Ryan Zarychanski, Ahmed Abou-Setta, Carol Friesen, Michael Tennenhouse and Barbara L Shay

    Citation: BMC Complementary and Alternative Medicine 2014 14:312

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  41. Content type: Study protocol

    The prevalence and socioeconomic cost of late life depression (LLD) is on the rise, while the response rate to antidepressant trials remains poor. Various mind-body therapies are being embraced by patients as ...

    Authors: Zareen Amtul, Amanda Arena, Hussein Hirjee, Zaineb U Khan, Pramudith M Maldeniya, Ronnie I Newman, Amer M Burhan, Stephen Wetmore and Akshya Vasudev

    Citation: BMC Complementary and Alternative Medicine 2014 14:307

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  42. Content type: Study protocol

    Abused women, who suffer from chronic psychological stress, have been shown to have shorter telomeres than never abused women. Telomere shortening is associated with increased risk of cell death, and it is bel...

    Authors: Agnes Tiwari, Cecilia Lai Wan Chan, Rainbow Tin Hung Ho, George Sai Wah Tsao, Wen Deng, Athena Wai Lin Hong, Daniel Yee Tak Fong, Helina Yin King Yuk Fung, Emily Pei Shin Pang, Denise Shuk Ting Cheung and Joyce Lai Chong Ma

    Citation: BMC Complementary and Alternative Medicine 2014 14:300

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  43. Content type: Study protocol

    In women with mixed urinary incontinence, pelvic floor muscle training and solifenacin is the recommended conservative treatment, while electroacupuncture is a safe, economical and effective option.

    Authors: Baoyan Liu, Yang Wang, Huanfang Xu, Yuelai Chen, Jiani Wu, Qian Mo and Zhishun Liu

    Citation: BMC Complementary and Alternative Medicine 2014 14:301

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  44. Content type: Research article

    Obesity is an important risk factor for cardiovascular and metabolic diseases and could affect mortality rates. Body mass index (BMI) and waist circumference (WC) have been used to classify obesity, and waist-...

    Authors: Younghwa Baek, Kihyun Park, Siwoo Lee and Eunsu Jang

    Citation: BMC Complementary and Alternative Medicine 2014 14:298

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  45. Content type: Research article

    Plantago ovata husk therapy could be used in patients with Parkinson disease to reduce the symptoms of gastrointestinal disorders, but it is important to know whether this compound modifies levodopa pharmacoki...

    Authors: M Nelida Fernandez-Martinez, Luis Hernandez-Echevarria, Matilde Sierra-Vega, M Jose Diez-Liebana, Angela Calle-Pardo, Demetrio Carriedo-Ule, Ana M Sahagún-Prieto, Anna Anguera-Vila and Juan Jose Garcia-Vieitez

    Citation: BMC Complementary and Alternative Medicine 2014 14:296

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  46. Content type: Study protocol

    Low back pain (LBP) is a major health issue due to its high prevalence rate and socioeconomic cost. While spinal manipulation (SM) is recommended for LBP treatment by recently published clinical guidelines, th...

    Authors: Ting Xia, David G Wilder, Maruti R Gudavalli, James W DeVocht, Robert D Vining, Katherine A Pohlman, Gregory N Kawchuk, Cynthia R Long and Christine M Goertz

    Citation: BMC Complementary and Alternative Medicine 2014 14:292

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  47. Content type: Research article

    Oral mucositis is one of the common complications of cancer chemotherapy and about 40% of the patients who take chemotherapy protocols, experience this irritating problem. The purpose of this study was to draw...

    Authors: Mohammad Ali Raeessi, Neda Raeessi, Yunes Panahi, Homa Gharaie, Seyyed Masoud Davoudi, Alireza Saadat, Ali Akbar Karimi Zarchi, Fereshteh Raeessi, Seyyed Mostafa Ahmadi and Hamidreza Jalalian

    Citation: BMC Complementary and Alternative Medicine 2014 14:293

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  48. Content type: Study protocol

    Stroke is one of the most common causes of cognitive impairment. Up to 75% of stroke survivors may be considered to have cognitive impairment, which severely limit individual autonomy for successful reintegrat...

    Authors: Shanli Yang, Haicheng Ye, Jia Huang, Jing Tao, Cai Jiang, Zhicheng Lin, Guohua Zheng and Lidian Chen

    Citation: BMC Complementary and Alternative Medicine 2014 14:290

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