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Clinical research

Edited by Holger Cramer, Jianping Liu and Karen Pilkington

This section covers research reporting clinical applications of interventions or resources in the complementary medicine field, including the evaluation of the efficacy and safety of the therapies, clinical trials and systematic reviews/meta-analysis.

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  1. Content type: Study protocol

    Caregiving can be stressful, potentially creating physical and psychological strain. Substantial evidence has shown that family caregivers suffer from significant health problems arising from the demands of ca...

    Authors: Agnes Tiwari, Lixing Lao, Amy Xiao-Min Wang, Denise Shuk Ting Cheung, Mike Ka Pui So, Doris Sau Fung Yu, Terry Yat Sang Lum, Helina Yin King Yuk Fung, Jerry Wing Fai Yeung and Zhang-Jin Zhang

    Citation: BMC Complementary and Alternative Medicine 2016 16:424

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  2. Content type: Study protocol

    Irritable bowel syndrome (IBS) is a worldwide disease with high morbidity. The effect of current treatment with Western medicine is not satisfactory. Although moxibustion treatment is widely used for gastroint...

    Authors: Chunhui Bao, Jingzhi Zhang, Jinmei Liu, Huirong Liu, Luyi Wu, Yin Shi, Jing Li, Zhihai Hu, Yongzheng Dong, Siyao Wang, Xiaoqing Zeng and Huangan Wu

    Citation: BMC Complementary and Alternative Medicine 2016 16:408

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  3. Content type: Research article

    In Japanese Kampo medical practice, suidoku (fluid disturbance) is one of the most important concepts for selecting the proper medication. Suidoku is an excessive or uneven distribution of fluid that is indica...

    Authors: Aya Murakami, Daisuke Kobayashi, Toshio Kubota, Niina Zukeyama, Haru Mukae, Norihiro Furusyo, Mosaburo Kainuma and Takao Shimazoe

    Citation: BMC Complementary and Alternative Medicine 2016 16:405

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  4. Content type: Study protocol

    Virgin olive oil, a recognized healthy food, cannot be consumed in great quantities. We aim to assess in humans whether an optimized virgin olive oil with high phenolic content (OVOO, 429 mg/Kg) and a function...

    Authors: Sara Biel, Maria-Dolores Mesa, Rafael de la Torre, Juan-Antonio Espejo, Jose-Ramón Fernández-Navarro, Montserrat Fitó, Estefanía Sánchez-Rodriguez, Carmen Rosa, Rosa Marchal, Juan de Dios Alche, Manuela Expósito, Manuel Brenes, Beatriz Gandul, Miguel Angel Calleja and María-Isabel Covas

    Citation: BMC Complementary and Alternative Medicine 2016 16:404

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  5. Content type: Research article

    Blood-stasis syndrome (BSS) is one of the Traditional Chinese medicine (TCM) syndrome differentiations that are commonly seen in stroke and ischemic heart diseases; however, the BSS differentiation criterion i...

    Authors: Jiangquan Liao, Yongmei Liu and Jie Wang

    Citation: BMC Complementary and Alternative Medicine 2016 16:371

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    The Erratum to this article has been published in BMC Complementary and Alternative Medicine 2016 16:458

  6. Content type: Research article

    Cerebral infarction frequently leads to mild cognitive impairment (MCI). Prompt management of MCI can prevent vascular dementia and improve patient outcome. This single center randomized controlled trial aims ...

    Authors: Shuhua Wang, Hongling Yang, Jie Zhang, Bin Zhang, Tao Liu, Lu Gan and Jiangang Zheng

    Citation: BMC Complementary and Alternative Medicine 2016 16:361

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  7. Content type: Research article

    The primary objective of this study was to assess whether Zhengtian Capsule was non-inferior to flunarizine in efficacy and safety profile for prevention of migraine in adults.

    Authors: Kegang Cao, Fang Han, Anji Lin, Wenming Yang, Jianjun Zhao, Hui Zhang, Yanbing Ding, Wei Xie, Yinping Xu, Tingmin Yu, Xinzhi Wang, Xiaosu Yang, Jiying Zhou, Qun Hou, Lihua Yu and Ying Gao

    Citation: BMC Complementary and Alternative Medicine 2016 16:356

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  8. Content type: Research article

    Chinese traditional “eye exercises of acupoints” have been advocated as a compulsory measure to reduce visual symptoms, as well as to retard the development of refractive error, among Chinese students for deca...

    Authors: Zhong Lin, Balamurali Vasudevan, Su Jie Fang, Vishal Jhanji, Guang Yun Mao, Wei Han, Tie Ying Gao, Kenneth J. Ciuffreda and Yuan Bo Liang

    Citation: BMC Complementary and Alternative Medicine 2016 16:349

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  9. Content type: Research article

    We aimed to evaluate the effect of an 8-week yoga intervention on the shoulder and spinal actions of women with breast cancer-related arm lymphoedema.

    Authors: Annette Loudon, Tony Barnett, Neil Piller, Maarten A. Immink, Denis Visentin and Andrew D. Williams

    Citation: BMC Complementary and Alternative Medicine 2016 16:343

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  10. Content type: Research article

    Current clinical practices used to functionally classify heart failure (HF) are time-consuming, expensive, or require complex calculations. This study aimed to design an inquiry list from the perspective of tr...

    Authors: Tieh-Cheng Fu, Yi-Chung Lin, Ching-Mao Chang, Wei-Ling Chou, Pei-Hsun Yuan, Min-Hui Liu, Chao-Hung Wang, Juei-Chao Chen, Hen-Hong Chang and Tai-Long Pan

    Citation: BMC Complementary and Alternative Medicine 2016 16:342

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  11. Content type: Research article

    Virus-induced dendritic cells (DCs) functional deficiency leads to sub-optimal initiation of adaptive immune responses and consequently chronic infection establishment. The present study reports an advanced he...

    Authors: Doaa A. Ghareeb, Eiman H. Elwakeel, Rowaida Khalil, Mina S. Aziz and Maha A. El demellawy

    Citation: BMC Complementary and Alternative Medicine 2016 16:325

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  12. Content type: Research article

    Diabetes mellitus (DM) is a hypercoagulable state and is associated with highly increased risk of vascular complications. In the theory of traditional Chinese medicine (TCM), these vascular complications are c...

    Authors: Po-Chi Hsu, Yu-Chuen Huang, John Y. Chiang, Hen-Hong Chang, Pei-Yung Liao and Lun-Chien Lo

    Citation: BMC Complementary and Alternative Medicine 2016 16:324

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  13. Content type: Research article

    Antrodia cinnamomea (AC) is a popular medicinal mushroom in Taiwan that has been widely used for treatment of various cancers. Few clinical studies have reported its application and ef...

    Authors: Ming-Yen Tsai, Yu-Chiang Hung, Yen-Hao Chen, Yung-Hsiang Chen, Yu-Chuen Huang, Chao-Wei Kao, Yu-Li Su, Hsien-Hsueh Elley Chiu and Kun-Ming Rau

    Citation: BMC Complementary and Alternative Medicine 2016 16:322

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  14. Content type: Research article

    Self-report measures indicate that Yoga practices are perceived to reduce stress; however, molecular mechanisms through which YB affects stress are just beginning to be understood. While invasive sampling such...

    Authors: Waleed O. Twal, Amy E. Wahlquist and Sundaravadivel Balasubramanian

    Citation: BMC Complementary and Alternative Medicine 2016 16:294

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  15. Content type: Research article

    With an estimated 65 million Diabetes Mellitus (DM) patients, India ranks second in the world in terms of DM burden. The emphasis of current medical practice has been on pharmacotherapy but, despite the best c...

    Authors: Srinivas Bairy, Ajay M. V. Kumar, MSN Raju, Shanta Achanta, Balaji Naik, Jaya P. Tripathy and Rony Zachariah

    Citation: BMC Complementary and Alternative Medicine 2016 16:290

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  16. Content type: Research article

    Despite the increasing number and variety of antiepileptic drugs, nearly 30 % of epileptic patients who receive appropriate medical attention have persisting seizures. Anticonvulsant activity has been demonstr...

    Authors: Germain Sotoing Taiwe, Bernard Dabole, Thierry Bang Tchoya, Joseph Renaud Menanga, Paul Désiré Djomeni Dzeufiet and Michel De Waard

    Citation: BMC Complementary and Alternative Medicine 2016 16:285

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  17. Content type: Research article

    Chronic pain can alter the autonomic balance with increased sympathetic activity reflected in altered heart rate variability (HRV). It has been proposed that yoga can be useful to correct the autonomic imbalan...

    Authors: Shirley Telles, Sachin Kumar Sharma, Ram Kumar Gupta, Abhishek Kumar Bhardwaj and Acharya Balkrishna

    Citation: BMC Complementary and Alternative Medicine 2016 16:279

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  18. Content type: Research article

    The purpose of this study is to investigate cardiovascular benefits of juices obtained from two commonly consumed fruits in Thailand, Pachyrhizus erosus, L. (yam bean) and Psidium guajava, L. (guava), by examinin...

    Authors: Thitiporn Thaptimthong, Thitima Kasemsuk, Nathawut Sibmooh and Supeenun Unchern

    Citation: BMC Complementary and Alternative Medicine 2016 16:269

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  19. Content type: Research article

    Osteoarthritic knee (OA knee) is a common condition in the elderly. Exploration of non-invasive complementary therapies for OA knee is warranted given the limitations of pharmacologic therapies. Auriculotherap...

    Authors: Lorna K. P. Suen, Chao Hsing Yeh and Simon K. W. Yeung

    Citation: BMC Complementary and Alternative Medicine 2016 16:257

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    The Erratum to this article has been published in BMC Complementary and Alternative Medicine 2016 16:391

  20. Content type: Research article

    Cardiovascular diseases are a main cause of mortality worldwide. Spa bathing and immersion in thermoneutral water (ITW) have a long history in the treatment of cardiovascular risk factors.

    Authors: Johannes Naumann, Catharina Sadaghiani, Nina Bureau, Stefan Schmidt and Roman Huber

    Citation: BMC Complementary and Alternative Medicine 2016 16:250

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  21. Content type: Research article

    Tangshen Formula (TSF) is a traditional Chinese medicine for the treatment of diabetic kidney disease (DKD). Liver-type fatty acid binding protein (L-FABP) is expressed in various tissues, including the kidney...

    Authors: Xin Yang, Bingxuan Zhang, Xiaoguang Lu, Meihua Yan, Yumin Wen, Tingting Zhao and Ping Li

    Citation: BMC Complementary and Alternative Medicine 2016 16:246

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  22. Content type: Research article

    Most subjects regain weight after weight loss due to compensatory adaptations finalized to maintain stable body energy stores. Green tea (GT) preparations, which help maintain energy expenditure while dieting ...

    Authors: Luisa Gilardini, Lucia Pasqualinotto, Francesco Di Pierro, Paolo Risso and Cecilia Invitti

    Citation: BMC Complementary and Alternative Medicine 2016 16:233

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  23. Content type: Research article

    This study aimed to investigate the effect of acupuncture administered immediately following a graded exercise test (GXT) on physiological measures of recovery and determine if instruction (expectancy) affecte...

    Authors: Paola Urroz, Ben Colagiuri, Caroline A. Smith, Alan Yeung and Birinder S. Cheema

    Citation: BMC Complementary and Alternative Medicine 2016 16:227

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  24. Content type: Research article

    Acupuncture is not considered a conventional therapy for post-stroke sequelae but it might have some additional positive effects on early rehabilitation. We conducted this trial to determine whether acupunctur...

    Authors: Lifang Chen, Jianqiao Fang, Ruijie Ma, Xudong Gu, Lina Chen, Jianhua Li and Shouyu Xu

    Citation: BMC Complementary and Alternative Medicine 2016 16:226

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  25. Content type: Research article

    Increased cellular ATP levels have the potential to enhance athletic performance. A proprietary blend of ancient peat and apple extracts has been supposed to increase ATP production. Therefore, the purpose of ...

    Authors: Jordan M. Joy, Roxanne M. Vogel, Jordan R. Moon, Paul H. Falcone, Matt M. Mosman, Zbigniew Pietrzkowski, Tania Reyes and Michael P. Kim

    Citation: BMC Complementary and Alternative Medicine 2016 16:224

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  26. Content type: Research article

    Primary insomnia is a widespread and refractory disease. Moxibustion therapy for insomnia shows some advantages compared with conventional therapies. This systematic review and meta-analysis of randomized cont...

    Authors: Yu-Jiao Sun, Jia-Min Yuan and Zhi-Min Yang

    Citation: BMC Complementary and Alternative Medicine 2016 16:217

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  27. Content type: Research article

    Tripterygium wilfordii Hook F (TwHF), a medicinal plant that has been widely used in Chinese traditional medicine, is proven effective for treating rheumatoid arthritis (RA), but its c...

    Authors: Hai-Long Wang, Quan Jiang, Xing-Hua Feng, Hua-Dong Zhang, Lin Ge, Cheng-Gui Luo, Xun Gong and Bo Li

    Citation: BMC Complementary and Alternative Medicine 2016 16:215

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  28. Content type: Research article

    Mesenteric phlebosclerosis (MP) is a disease characterized by fibrotic change or calcification of the mesenteric vein. Recently, there has been an increase in case reports of MP related to herbal medicine usag...

    Authors: Yutaka Nagata, Tetsuo Watanabe, Kazuhiko Nagasaka, Masaaki Yamada, Masafumi Murai, Sunao Takeuchi, Mai Murase, Toshinori Yazaki, Takayuki Murase, Kenichi Komatsu, Machiko Kaizuka, Mika Sano, Koji Asano, Chikao Ando and Norihide Taniuchi

    Citation: BMC Complementary and Alternative Medicine 2016 16:207

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  29. Content type: Research article

    Qili Qiangxin capsule is a standardized Chinese herbal treatment that is commonly used in China for heart failure (HF) alongside conventional medical care. In 2014, Chinese guidelines for the treatment of chro...

    Authors: Jin Sun, Kang Zhang, Wen-Jing Xiong, Guo-Yan Yang, Yun-Jiao Zhang, Cong-Cong Wang, Lily Lai, Mei Han, Jun Ren, George Lewith and Jian-Ping Liu

    Citation: BMC Complementary and Alternative Medicine 2016 16:201

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  30. Content type: Research article

    The use of Complementary and Alternative Medicine (CAM) has been increasing over the years. A recent review of adverse event reports (AERs) associated with CAM in Singapore found a notable number of AERs submi...

    Authors: Desmond Chun Hwee Teo, Patricia Suet Leng Ng, Siew Har Tan, Adena Theen Lim, Dorothy Su Lin Toh, Sui Yung Chan and Han Hui Cheong

    Citation: BMC Complementary and Alternative Medicine 2016 16:192

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  31. Content type: Study protocol

    Cerebral palsy leads to many complications as well as delayed motor development, and early intensive rehabilitation in infancy, which is based on the theory of brain plasticity, is emphasized. In addition to c...

    Authors: Jeong-Eun Yoo, Young-Ju Yun, Yong-Beom Shin, Nam-kwen Kim, Soo-Yeon Kim, Myung-Jun Shin and Sun-ae Yu

    Citation: BMC Complementary and Alternative Medicine 2016 16:172

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  32. Content type: Research article

    Hitherto no study has been published on the effect of the adjunctive administration of essential oils following scaling and root planing (SRP). This study describes the effect of a mouthrinse consisting of ess...

    Authors: Mohammad Fallah Azad, Andreas Schwiertz and Holger F. R. Jentsch

    Citation: BMC Complementary and Alternative Medicine 2016 16:171

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  33. Content type: Research article

    Muscle damage induced by unaccustomed or eccentric exercise results in delayed onset vascular stiffening. We tested the hypothesis that a 7-day supplementation of panax ginseng and salvia miltiorrhiza prior to an...

    Authors: Hsin-Fu Lin, Kang Tung, Chun-Chung Chou, Ching-Che Lin, Jaung-Geng Lin and Hirofumi Tanaka

    Citation: BMC Complementary and Alternative Medicine 2016 16:168

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  34. Content type: Research article

    Clinical history-taking can be employed as a standardized approach to elucidate the use of herbal medicines and their linked suspected adverse drug reactions (ADRs) among hospitalized patients. We sought to id...

    Authors: Ronald Kiguba, Sam Ononge, Charles Karamagi and Sheila M. Bird

    Citation: BMC Complementary and Alternative Medicine 2016 16:145

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  35. Content type: Research article

    During Flotation-REST a person is floating inside a quiet and dark tank, filled with heated salt saturated water. Deep relaxation and beneficial effects on e.g. stress, sleep difficulties, anxiety and depressi...

    Authors: Kristoffer Jonsson and Anette Kjellgren

    Citation: BMC Complementary and Alternative Medicine 2016 16:108

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  36. Content type: Case report

    Immune thrombocytopenia (ITP) is a hematological disorder with an isolated decrease in number of circulating platelets. Bee venom therapy (BVT) is a form of alternative medicine. It is still being practiced in...

    Authors: Mohammad Adel Abdulsalam, Bader Esmael Ebrahim and Ahmad Jasem Abdulsalam

    Citation: BMC Complementary and Alternative Medicine 2016 16:107

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  37. Content type: Research article

    Patients who sustain a motor vehicle accident may experience long-term distress, even if they are uninjured or only slightly injured. There is a risk of neglecting patients with minor or no physical injuries, ...

    Authors: Fanny Airosa, Maria Arman, Tobias Sundberg, Gunnar Öhlén and Torkel Falkenberg

    Citation: BMC Complementary and Alternative Medicine 2016 16:106

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  38. Content type: Study protocol

    Although higher habitual soy intake is associated with lower blood pressure (BP) and stroke incidence, clinical trials using soy protein or isoflavones on cardiovascular risks yielded inconsistent results. The...

    Authors: Zhao-min Liu, Suzanne C. Ho, Yu-ming Chen, Yao Jie Xie, Zhi-guan Huang and Wen-hua Ling

    Citation: BMC Complementary and Alternative Medicine 2016 16:89

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  39. Content type: Research article

    Acupuncture is applied for treating numerous conditions in children, but few studies have examined the safe needling depth of acupoints in the pediatric population. In this study, we investigated the depths to...

    Authors: Yi-Chun Ma, Ching-Tien Peng, Yu-Chuen Huang, Hung-Yi Lin and Jaung-Geng Lin

    Citation: BMC Complementary and Alternative Medicine 2016 16:85

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  40. Content type: Research article

    Recurrent respiratory tract infections (RRTIs) have a negative impact on both children’s health and family wellbeing. Deficiency of ZhengQi used to be an instinct factor driving RRTI in Traditional Chinese Med...

    Authors: Fei Dong, He Yu, Jiaju Ma, Liqun Wu, Tiegang Liu, Guokai Lv, Jianhua Zhen, Xiaofei Li, George Lewith and Xiaohong Gu

    Citation: BMC Complementary and Alternative Medicine 2016 16:82

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  41. Content type: Study protocol

    The EUDAIMON study focuses on fibromyalgia syndrome (FMS), a prevalent chronic condition characterized by pain, fatigue, cognitive problems and distress. According to recent reviews and meta-analyses, Mindfuln...

    Authors: Albert Feliu-Soler, Xavier Borràs, María T. Peñarrubia-María, Antoni Rozadilla-Sacanell, Francesco D’Amico, Rona Moss-Morris, Matthew A. Howard, Nicolás Fayed, Carles Soriano-Mas, Marta Puebla-Guedea, Antoni Serrano-Blanco, Adrián Pérez-Aranda, Raffaele Tuccillo and Juan V. Luciano

    Citation: BMC Complementary and Alternative Medicine 2016 16:81

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  42. Content type: Research article

    To appraise critically whether published trials of ShenXiong glucose injection for patients with acute ischemic stroke (AIS) are of sufficient quality, and in addition to rate the quality of evidence by using ...

    Authors: Xue-ting Liu, Peng-wei Ren, Le Peng, De-ying Kang, Tian-le Zhang, Shu Wen, Qi Hong and Wen-jie Yang

    Citation: BMC Complementary and Alternative Medicine 2016 16:68

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  43. Content type: Research article

    Of patients undergoing surgery, 22 to 57 % have been reported to be using naturopathic medicines. Several of these medicines have been reported to increase bleeding or enhance the effect of other drugs that in...

    Authors: August Bagge, Ulf Schött and Thomas Kander

    Citation: BMC Complementary and Alternative Medicine 2016 16:64

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  44. Content type: Research article

    The hypertriglyceridemic waist (HW) phenotype has been shown to be strongly associated with metabolic abnormalities; however, to date, no study has reported the prediction of metabolic abnormalities using the ...

    Authors: Bum Ju Lee, Jiho Nam and Jong Yeol Kim

    Citation: BMC Complementary and Alternative Medicine 2016 16:59

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  45. Content type: Study protocol

    Integrative medicine (IM) provides patient-centered care and addresses the full range of physical, emotional, mental, social, spiritual, and environmental influences that affect a person’s health. IM is a “who...

    Authors: Jeffery A. Dusek, Donald I. Abrams, Rhonda Roberts, Kristen H. Griffin, Desiree Trebesch, Rowena J. Dolor, Ruth Q. Wolever, M. Diane McKee and Benjamin Kligler

    Citation: BMC Complementary and Alternative Medicine 2016 16:53

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  46. Content type: Research article

    Symptomatic cervical intervertebral disc herniation (IDH) presenting as neck pain accompanied by arm pain is a common affliction whose prevalence continues to rise, and is a frequent reason for integrative inp...

    Authors: Sang Hyun Baek, Jae Woo Oh, Joon-Shik Shin, Jinho Lee, Yoon Jae Lee, Me-riong Kim, Yong-jun Ahn, Areum Choi, Ki Byung Park, Byung-Cheul Shin, Myeong Soo Lee and In-Hyuk Ha

    Citation: BMC Complementary and Alternative Medicine 2016 16:52

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  47. Content type: Study protocol

    Despite high quality stroke care, decreased sensorimotor function, anxiety and pain often remain one year after stroke which can lead to impaired health and dependence, as well as higher healthcare costs. Touc...

    Authors: Kristina Lämås, Charlotte Häger, Lenita Lindgren, Per Wester and Christine Brulin

    Citation: BMC Complementary and Alternative Medicine 2016 16:50

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