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Clinical research

Edited by Holger Cramer, Jianping Liu and Karen Pilkington

This section covers research reporting clinical applications of interventions or resources in the complementary medicine field, including the evaluation of the efficacy and safety of the therapies, clinical trials and systematic reviews/meta-analysis.

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  1. Content type: Research article

    Chronic pain can alter the autonomic balance with increased sympathetic activity reflected in altered heart rate variability (HRV). It has been proposed that yoga can be useful to correct the autonomic imbalan...

    Authors: Shirley Telles, Sachin Kumar Sharma, Ram Kumar Gupta, Abhishek Kumar Bhardwaj and Acharya Balkrishna

    Citation: BMC Complementary and Alternative Medicine 2016 16:279

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  2. Content type: Research article

    The purpose of this study is to investigate cardiovascular benefits of juices obtained from two commonly consumed fruits in Thailand, Pachyrhizus erosus, L. (yam bean) and Psidium guajava, L. (guava), by examinin...

    Authors: Thitiporn Thaptimthong, Thitima Kasemsuk, Nathawut Sibmooh and Supeenun Unchern

    Citation: BMC Complementary and Alternative Medicine 2016 16:269

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  3. Content type: Research article

    Osteoarthritic knee (OA knee) is a common condition in the elderly. Exploration of non-invasive complementary therapies for OA knee is warranted given the limitations of pharmacologic therapies. Auriculotherap...

    Authors: Lorna K. P. Suen, Chao Hsing Yeh and Simon K. W. Yeung

    Citation: BMC Complementary and Alternative Medicine 2016 16:257

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    The Erratum to this article has been published in BMC Complementary and Alternative Medicine 2016 16:391

  4. Content type: Research article

    Cardiovascular diseases are a main cause of mortality worldwide. Spa bathing and immersion in thermoneutral water (ITW) have a long history in the treatment of cardiovascular risk factors.

    Authors: Johannes Naumann, Catharina Sadaghiani, Nina Bureau, Stefan Schmidt and Roman Huber

    Citation: BMC Complementary and Alternative Medicine 2016 16:250

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  5. Content type: Research article

    Tangshen Formula (TSF) is a traditional Chinese medicine for the treatment of diabetic kidney disease (DKD). Liver-type fatty acid binding protein (L-FABP) is expressed in various tissues, including the kidney...

    Authors: Xin Yang, Bingxuan Zhang, Xiaoguang Lu, Meihua Yan, Yumin Wen, Tingting Zhao and Ping Li

    Citation: BMC Complementary and Alternative Medicine 2016 16:246

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  6. Content type: Research article

    Most subjects regain weight after weight loss due to compensatory adaptations finalized to maintain stable body energy stores. Green tea (GT) preparations, which help maintain energy expenditure while dieting ...

    Authors: Luisa Gilardini, Lucia Pasqualinotto, Francesco Di Pierro, Paolo Risso and Cecilia Invitti

    Citation: BMC Complementary and Alternative Medicine 2016 16:233

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  7. Content type: Research article

    This study aimed to investigate the effect of acupuncture administered immediately following a graded exercise test (GXT) on physiological measures of recovery and determine if instruction (expectancy) affecte...

    Authors: Paola Urroz, Ben Colagiuri, Caroline A. Smith, Alan Yeung and Birinder S. Cheema

    Citation: BMC Complementary and Alternative Medicine 2016 16:227

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  8. Content type: Research article

    Acupuncture is not considered a conventional therapy for post-stroke sequelae but it might have some additional positive effects on early rehabilitation. We conducted this trial to determine whether acupunctur...

    Authors: Lifang Chen, Jianqiao Fang, Ruijie Ma, Xudong Gu, Lina Chen, Jianhua Li and Shouyu Xu

    Citation: BMC Complementary and Alternative Medicine 2016 16:226

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  9. Content type: Research article

    Increased cellular ATP levels have the potential to enhance athletic performance. A proprietary blend of ancient peat and apple extracts has been supposed to increase ATP production. Therefore, the purpose of ...

    Authors: Jordan M. Joy, Roxanne M. Vogel, Jordan R. Moon, Paul H. Falcone, Matt M. Mosman, Zbigniew Pietrzkowski, Tania Reyes and Michael P. Kim

    Citation: BMC Complementary and Alternative Medicine 2016 16:224

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  10. Content type: Research article

    Primary insomnia is a widespread and refractory disease. Moxibustion therapy for insomnia shows some advantages compared with conventional therapies. This systematic review and meta-analysis of randomized cont...

    Authors: Yu-Jiao Sun, Jia-Min Yuan and Zhi-Min Yang

    Citation: BMC Complementary and Alternative Medicine 2016 16:217

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  11. Content type: Research article

    Tripterygium wilfordii Hook F (TwHF), a medicinal plant that has been widely used in Chinese traditional medicine, is proven effective for treating rheumatoid arthritis (RA), but its c...

    Authors: Hai-Long Wang, Quan Jiang, Xing-Hua Feng, Hua-Dong Zhang, Lin Ge, Cheng-Gui Luo, Xun Gong and Bo Li

    Citation: BMC Complementary and Alternative Medicine 2016 16:215

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  12. Content type: Research article

    Qili Qiangxin capsule is a standardized Chinese herbal treatment that is commonly used in China for heart failure (HF) alongside conventional medical care. In 2014, Chinese guidelines for the treatment of chro...

    Authors: Jin Sun, Kang Zhang, Wen-Jing Xiong, Guo-Yan Yang, Yun-Jiao Zhang, Cong-Cong Wang, Lily Lai, Mei Han, Jun Ren, George Lewith and Jian-Ping Liu

    Citation: BMC Complementary and Alternative Medicine 2016 16:201

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  13. Content type: Research article

    Mesenteric phlebosclerosis (MP) is a disease characterized by fibrotic change or calcification of the mesenteric vein. Recently, there has been an increase in case reports of MP related to herbal medicine usag...

    Authors: Yutaka Nagata, Tetsuo Watanabe, Kazuhiko Nagasaka, Masaaki Yamada, Masafumi Murai, Sunao Takeuchi, Mai Murase, Toshinori Yazaki, Takayuki Murase, Kenichi Komatsu, Machiko Kaizuka, Mika Sano, Koji Asano, Chikao Ando and Norihide Taniuchi

    Citation: BMC Complementary and Alternative Medicine 2016 16:207

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  14. Content type: Research article

    The use of Complementary and Alternative Medicine (CAM) has been increasing over the years. A recent review of adverse event reports (AERs) associated with CAM in Singapore found a notable number of AERs submi...

    Authors: Desmond Chun Hwee Teo, Patricia Suet Leng Ng, Siew Har Tan, Adena Theen Lim, Dorothy Su Lin Toh, Sui Yung Chan and Han Hui Cheong

    Citation: BMC Complementary and Alternative Medicine 2016 16:192

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  15. Content type: Study protocol

    Cerebral palsy leads to many complications as well as delayed motor development, and early intensive rehabilitation in infancy, which is based on the theory of brain plasticity, is emphasized. In addition to c...

    Authors: Jeong-Eun Yoo, Young-Ju Yun, Yong-Beom Shin, Nam-kwen Kim, Soo-Yeon Kim, Myung-Jun Shin and Sun-ae Yu

    Citation: BMC Complementary and Alternative Medicine 2016 16:172

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  16. Content type: Research article

    Hitherto no study has been published on the effect of the adjunctive administration of essential oils following scaling and root planing (SRP). This study describes the effect of a mouthrinse consisting of ess...

    Authors: Mohammad Fallah Azad, Andreas Schwiertz and Holger F. R. Jentsch

    Citation: BMC Complementary and Alternative Medicine 2016 16:171

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  17. Content type: Research article

    Muscle damage induced by unaccustomed or eccentric exercise results in delayed onset vascular stiffening. We tested the hypothesis that a 7-day supplementation of panax ginseng and salvia miltiorrhiza prior to an...

    Authors: Hsin-Fu Lin, Kang Tung, Chun-Chung Chou, Ching-Che Lin, Jaung-Geng Lin and Hirofumi Tanaka

    Citation: BMC Complementary and Alternative Medicine 2016 16:168

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  18. Content type: Research article

    Clinical history-taking can be employed as a standardized approach to elucidate the use of herbal medicines and their linked suspected adverse drug reactions (ADRs) among hospitalized patients. We sought to id...

    Authors: Ronald Kiguba, Sam Ononge, Charles Karamagi and Sheila M. Bird

    Citation: BMC Complementary and Alternative Medicine 2016 16:145

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  19. Content type: Research article

    During Flotation-REST a person is floating inside a quiet and dark tank, filled with heated salt saturated water. Deep relaxation and beneficial effects on e.g. stress, sleep difficulties, anxiety and depressi...

    Authors: Kristoffer Jonsson and Anette Kjellgren

    Citation: BMC Complementary and Alternative Medicine 2016 16:108

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  20. Content type: Case report

    Immune thrombocytopenia (ITP) is a hematological disorder with an isolated decrease in number of circulating platelets. Bee venom therapy (BVT) is a form of alternative medicine. It is still being practiced in...

    Authors: Mohammad Adel Abdulsalam, Bader Esmael Ebrahim and Ahmad Jasem Abdulsalam

    Citation: BMC Complementary and Alternative Medicine 2016 16:107

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  21. Content type: Research article

    Patients who sustain a motor vehicle accident may experience long-term distress, even if they are uninjured or only slightly injured. There is a risk of neglecting patients with minor or no physical injuries, ...

    Authors: Fanny Airosa, Maria Arman, Tobias Sundberg, Gunnar Öhlén and Torkel Falkenberg

    Citation: BMC Complementary and Alternative Medicine 2016 16:106

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  22. Content type: Study protocol

    Although higher habitual soy intake is associated with lower blood pressure (BP) and stroke incidence, clinical trials using soy protein or isoflavones on cardiovascular risks yielded inconsistent results. The...

    Authors: Zhao-min Liu, Suzanne C. Ho, Yu-ming Chen, Yao Jie Xie, Zhi-guan Huang and Wen-hua Ling

    Citation: BMC Complementary and Alternative Medicine 2016 16:89

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  23. Content type: Study protocol

    The EUDAIMON study focuses on fibromyalgia syndrome (FMS), a prevalent chronic condition characterized by pain, fatigue, cognitive problems and distress. According to recent reviews and meta-analyses, Mindfuln...

    Authors: Albert Feliu-Soler, Xavier Borràs, María T. Peñarrubia-María, Antoni Rozadilla-Sacanell, Francesco D’Amico, Rona Moss-Morris, Matthew A. Howard, Nicolás Fayed, Carles Soriano-Mas, Marta Puebla-Guedea, Antoni Serrano-Blanco, Adrián Pérez-Aranda, Raffaele Tuccillo and Juan V. Luciano

    Citation: BMC Complementary and Alternative Medicine 2016 16:81

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  24. Content type: Research article

    Acupuncture is applied for treating numerous conditions in children, but few studies have examined the safe needling depth of acupoints in the pediatric population. In this study, we investigated the depths to...

    Authors: Yi-Chun Ma, Ching-Tien Peng, Yu-Chuen Huang, Hung-Yi Lin and Jaung-Geng Lin

    Citation: BMC Complementary and Alternative Medicine 2016 16:85

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  25. Content type: Research article

    Recurrent respiratory tract infections (RRTIs) have a negative impact on both children’s health and family wellbeing. Deficiency of ZhengQi used to be an instinct factor driving RRTI in Traditional Chinese Med...

    Authors: Fei Dong, He Yu, Jiaju Ma, Liqun Wu, Tiegang Liu, Guokai Lv, Jianhua Zhen, Xiaofei Li, George Lewith and Xiaohong Gu

    Citation: BMC Complementary and Alternative Medicine 2016 16:82

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  26. Content type: Research article

    To appraise critically whether published trials of ShenXiong glucose injection for patients with acute ischemic stroke (AIS) are of sufficient quality, and in addition to rate the quality of evidence by using ...

    Authors: Xue-ting Liu, Peng-wei Ren, Le Peng, De-ying Kang, Tian-le Zhang, Shu Wen, Qi Hong and Wen-jie Yang

    Citation: BMC Complementary and Alternative Medicine 2016 16:68

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  27. Content type: Research article

    Of patients undergoing surgery, 22 to 57 % have been reported to be using naturopathic medicines. Several of these medicines have been reported to increase bleeding or enhance the effect of other drugs that in...

    Authors: August Bagge, Ulf Schött and Thomas Kander

    Citation: BMC Complementary and Alternative Medicine 2016 16:64

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  28. Content type: Research article

    The hypertriglyceridemic waist (HW) phenotype has been shown to be strongly associated with metabolic abnormalities; however, to date, no study has reported the prediction of metabolic abnormalities using the ...

    Authors: Bum Ju Lee, Jiho Nam and Jong Yeol Kim

    Citation: BMC Complementary and Alternative Medicine 2016 16:59

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  29. Content type: Study protocol

    Integrative medicine (IM) provides patient-centered care and addresses the full range of physical, emotional, mental, social, spiritual, and environmental influences that affect a person’s health. IM is a “who...

    Authors: Jeffery A. Dusek, Donald I. Abrams, Rhonda Roberts, Kristen H. Griffin, Desiree Trebesch, Rowena J. Dolor, Ruth Q. Wolever, M. Diane McKee and Benjamin Kligler

    Citation: BMC Complementary and Alternative Medicine 2016 16:53

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  30. Content type: Research article

    Symptomatic cervical intervertebral disc herniation (IDH) presenting as neck pain accompanied by arm pain is a common affliction whose prevalence continues to rise, and is a frequent reason for integrative inp...

    Authors: Sang Hyun Baek, Jae Woo Oh, Joon-Shik Shin, Jinho Lee, Yoon Jae Lee, Me-riong Kim, Yong-jun Ahn, Areum Choi, Ki Byung Park, Byung-Cheul Shin, Myeong Soo Lee and In-Hyuk Ha

    Citation: BMC Complementary and Alternative Medicine 2016 16:52

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  31. Content type: Study protocol

    Despite high quality stroke care, decreased sensorimotor function, anxiety and pain often remain one year after stroke which can lead to impaired health and dependence, as well as higher healthcare costs. Touc...

    Authors: Kristina Lämås, Charlotte Häger, Lenita Lindgren, Per Wester and Christine Brulin

    Citation: BMC Complementary and Alternative Medicine 2016 16:50

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  32. Content type: Study protocol

    The purpose of this study is to evaluate the efficacy and safety of myofascial-meridian release acupuncture (MMRA) in the treatment of chronic neck pain compared with sham acupuncture.

    Authors: Seunghoon Lee, Dongwoo Nam, Jungtae Leem, Gajin Han, Seungmin Lee and Junhee Lee

    Citation: BMC Complementary and Alternative Medicine 2016 16:45

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  33. Content type: Study protocol

    Although various placebo acupuncture devices have been developed and used in acupuncture research, there is controversy concerning whether these devices really serve as appropriate placebos for control groups.

    Authors: Jungtae Leem, Jimin Park, Gajin Han, Seulgi Eun, Meena M. Makary, Kyungmo Park, Junhee Lee and Sanghoon Lee

    Citation: BMC Complementary and Alternative Medicine 2016 16:43

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  34. Content type: Study protocol

    Chronic cough, defined it lasts more than 8 weeks. The symptom is common, but highly troublesome, and it reduces quality of life. Despite much effort to develop a protocol for diagnosis and treatment of chroni...

    Authors: Kwan-Il Kim, Seungwon Shin, Kyuseok Kim and Junhee Lee

    Citation: BMC Complementary and Alternative Medicine 2016 16:46

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  35. Content type: Research article

    Probiotics have rarely been studied in young healthy infants from low-income countries. This phase I study investigated the safety and acceptability of two probiotics in Bangladesh.

    Authors: Yana Emmy Hoy-Schulz, Kaniz Jannat, Thomas Roberts, Saira Husain Zaidi, Leanne Unicomb, Stephen Luby and Julie Parsonnet

    Citation: BMC Complementary and Alternative Medicine 2016 16:44

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  36. Content type: Research article

    Transcutaneous acupoint electrical stimulation (TAES) as a needleless acupuncture has the same effect like traditional manual acupuncture. The combination of TAES and anesthesia has been proved valid in enhanc...

    Authors: Xing Liu, Jing Wang, Baoguo Wang, Ying Hua Wang, Qinglei Teng, Jiaqing Yan, Shuangyan Wang and You Wan

    Citation: BMC Complementary and Alternative Medicine 2016 16:33

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  37. Content type: Study protocol

    Due to increasing interest from acne patients concerned about the side effects associated with conventional therapies, complementary and alternative medicine (CAM) has been suggested as a new therapeutic modal...

    Authors: Kyuseok Kim, Kwan-Il Kim and Junhee Lee

    Citation: BMC Complementary and Alternative Medicine 2016 16:21

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  38. Content type: Study protocol

    The treatment of low back pain is very challenging due to the recurrent nature of the problem. It is believed that traditional Malay massage helps to relieve such back pain but there is a lack of scientific ev...

    Authors: Nurhanisah Sejari, Kamaria Kamaruddin, Kalavathy Ramasamy, Siong Meng Lim, Chin Fen Neoh and Long Chiau Ming

    Citation: BMC Complementary and Alternative Medicine 2016 16:16

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  39. Content type: Research article

    Nausea and vomiting in pregnancy (NVP) and hyperemesis gravidarum (HG) have a significant impact on quality of life. Medication to relieve symptoms of NVP and HG are available but pregnant women and their care...

    Authors: Els Van den Heuvel, Maria Goossens, Hilde Vanderhaegen, Hai Xia Sun and Frank Buntinx

    Citation: BMC Complementary and Alternative Medicine 2016 16:13

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  40. Content type: Research article

    Sailuotong (SLT) is a standardised herbal medicine formula consisting of Panax ginseng, Ginkgo biloba, and Crocus sativus, and has been designed to enhance cognitive and cardiovascular function.

    Authors: Genevieve Z. Steiner, Alan Yeung, Jian-Xun Liu, David A. Camfield, Frances M. de Blasio, Andrew Pipingas, Andrew B. Scholey, Con Stough and Dennis H. Chang

    Citation: BMC Complementary and Alternative Medicine 2016 16:15

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  41. Content type: Research article

    It is important that potential study participants are appropriately informed and understand what is involved with their research participation. A few studies have examined study participants’ understanding of ...

    Authors: Caroline A. Smith and Sarah Fogarty

    Citation: BMC Complementary and Alternative Medicine 2016 16:10

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  42. Content type: Research article

    Functional dyspepsia (FD), which is a very common disorder worldwide, is known to be caused by multiple factors including environmental and genetic factors. Sasang constitutional medicine (SCM) is a component ...

    Authors: Yoon Jeong Kim, Yo Chan Ahn and Chang Gue Son

    Citation: BMC Complementary and Alternative Medicine 2015 15:150

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  43. Content type: Research article

    Cystic fibrosis (CF) leads to advanced lung disease despite aggressive care. Persistent inflammation and oxidative stress contribute to exacerbations and disease progression. Flaxseed (FS), a dietary botanical...

    Authors: Jason B Turowski, Ralph A Pietrofesa, John A Lawson, Melpo Christofidou-Solomidou and Denis Hadjiliadis

    Citation: BMC Complementary and Alternative Medicine 2015 15:148

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  44. Content type: Research article

    Dementia is a prevalent neurodegenerative disorder affecting an estimated 24.3 million people across the globe. The burden on those caring for people with dementia is substantial, with widespread implications ...

    Authors: Matthew J. Leach, Andrew Francis and Tahereh Ziaian

    Citation: BMC Complementary and Alternative Medicine 2015 15:145

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  45. Content type: Research article

    Chronic tension-type headache (CTTH) is characterized by almost daily headaches and central sensitization, for which electroacupuncture (EA) might be effective. The central nervous system (CNS) plasticity can ...

    Authors: Mônica Chassot, Jairo Alberto Dussan-Sarria, Francislea Cristina Sehn, Alícia Deitos, Andressa de Souza, Rafael Vercelino, Iraci LS Torres, Felipe Fregni and Wolnei Caumo

    Citation: BMC Complementary and Alternative Medicine 2015 15:144

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  46. Content type: Study protocol

    Angina pectoris (Angina) is a medical condition related to myocardial ischemia. Although acupuncture has been widely accepted as a clinical approach for angina, there is no sufficient evidence of its effective...

    Authors: Ning Wang, Sheng-Feng Lu, Hui Chen, Jian-Fei Wang, Shu-Ping Fu, Chen-Jun Hu, Yi Yang, Fan-Rong Liang and Bing-Mei Zhu

    Citation: BMC Complementary and Alternative Medicine 2015 15:139

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  47. Content type: Research article

    Psychological distress is associated with impaired health-related quality of life (HRQL) and poor sense of coherence (SOC). In a previous study, we found that therapeutic acupuncture (TA) and an integrative tr...

    Authors: Tina Arvidsdotter, Bertil Marklund, Charles Taft and Sven Kylén

    Citation: BMC Complementary and Alternative Medicine 2015 15:132

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  48. Content type: Research article

    Chinese medicine is commonly used and covered by health insurance to treat symptoms of uterine fibroids in Taiwan. This retrospective cohort study compared the consumption of conventional western medicine and ...

    Authors: Shan-Yu Su, Chih-Hsin Muo and Donald E Morisky

    Citation: BMC Complementary and Alternative Medicine 2015 15:129

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