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Clinical research

Edited by Holger Cramer, Jianping Liu and Karen Pilkington

This section covers research reporting clinical applications of interventions or resources in the complementary medicine field, including the evaluation of the efficacy and safety of the therapies, clinical trials and systematic reviews/meta-analysis.

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  1. Content type: Research article

    Dogs are the most common companion animal, and therefore not surprisingly a popular choice for animal-assisted interventions. Dog-assisted interventions are increasingly used in healthcare. The aim of the revi...

    Authors: Martina Lundqvist, Per Carlsson, Rune Sjödahl, Elvar Theodorsson and Lars-Åke Levin

    Citation: BMC Complementary and Alternative Medicine 2017 17:358

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  2. Content type: Study protocol

    Stroke presents a serious health problem in China. Despite progresses made in recent years, there is still a lack of effective treatments for acute ischemic stroke (AIS) in clinical practices.

    Authors: Weiping Sun, Qianhua Ou, Zhijun Zhang, Jiazhi Qu and Yining Huang

    Citation: BMC Complementary and Alternative Medicine 2017 17:357

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  3. Content type: Study protocol

    Cancer-related fatigue is one of the most common symptoms experienced by cancer patients, and it diminishes their quality of life. However, there is currently no confirmed standard treatment for cancer-related...

    Authors: Mikyung Kim, Jung-Eun Kim, Hye-Yoon Lee, Ae-Ran Kim, Hyo-Ju Park, O-Jin Kwon, Eun-Jung Kim, Yeon-Cheol Park, Byung-Kwan Seo, Jung Hyo Cho and Joo-Hee Kim

    Citation: BMC Complementary and Alternative Medicine 2017 17:353

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  4. Content type: Research article

    The psychophysical responses induced by verum acupuncture are characterized by a constellation of unique subjective sensory responses commonly termed De Qi. Furthermore, a variety of sham interventions have be...

    Authors: Shohreh Razavy, Marcus Gadau, Shi Ping Zhang, Fu Chun Wang, Sergio Bangrazi, Christine Berle, Mahrita Harahap, Tie Li, Wei Hong Li and Christopher Zaslawski

    Citation: BMC Complementary and Alternative Medicine 2017 17:348

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  5. Content type: Research article

    Pain is a common symptom in cancer patients. Acupuncture is a suggested treatment for a wide range of clinical conditions, usually for its beneficial effects on pain control. Si guan xue (the four points) have be...

    Authors: To-Yi Lam, Li-Ming Lu, Wai-Man Ling and Li-Zhu Lin

    Citation: BMC Complementary and Alternative Medicine 2017 17:335

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  6. Content type: Research article

    Quality of life has become an important aspect in the measurement of the health of an individual as the population ages. Rhythm-centred music making (RMM) has been shown to improve physical, psychological and ...

    Authors: Angela Frances Yap, Yu Heng Kwan, Chuen Seng Tan, Syed Ibrahim and Seng Bin Ang

    Citation: BMC Complementary and Alternative Medicine 2017 17:311

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  7. Content type: Research article

    Traditional Chinese medicine (TCM) has a long history in the treatment of psoriasis vulgaris. We aimed to evaluate the clinical efficacy and safety of Chinese herbal Pulian ointment in treating psoriasis vulga...

    Authors: Nuo Li, Wenbin Zhao, Jianmin Xing, Jianping Liu, Guangzhong Zhang, Yunbi Zhang, Yuanwen Li, Wali Liu, Fei Shi and Yanping Bai

    Citation: BMC Complementary and Alternative Medicine 2017 17:264

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  8. Content type: Research article

    Despite advances in the treatment of depression, one-third of depressed patients fail to respond to conventional antidepressant medication. There is a need for more effective treatments with fewer side effects. T...

    Authors: Johannes Naumann, Julian Grebe, Sonja Kaifel, Tomas Weinert, Catharina Sadaghiani and Roman Huber

    Citation: BMC Complementary and Alternative Medicine 2017 17:172

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  9. Content type: Research article

    Only a small number of articles have investigated the relationship between mindfulness-based interventions (MBIs) and biomarkers. The aim of this systematic review was to study the effect of MBIs on specific b...

    Authors: Kenji Sanada, Marta Alda Díez, Montserrat Salas Valero, María C. Pérez-Yus, Marcelo M. P. Demarzo, Jesús Montero-Marín, Mauro García-Toro and Javier García-Campayo

    Citation: BMC Complementary and Alternative Medicine 2017 17:125

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  10. Content type: Study protocol

    Thalamic hemorrhage (TH) is a neurological insult with a high rate of morbidity and mortality. Moderate TH (10–30 ml) accounts for more than half of all TH. Treatment remains controversial. The role of acupunc...

    Authors: Chengwei Wang, Chao You, Lu Ma, Mengyue Liu, Meng Tian and Ning Li

    Citation: BMC Complementary and Alternative Medicine 2017 17:112

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  11. Content type: Research article

    Qianggu Capsule, a Chinese patent medicine, has been widely applied in the clinical practice of primary osteoporosis (POP) in recent years. This study aims to summarize the effectiveness and safety of Qianggu ...

    Authors: Xu Wei, Aili Xu, Hao Shen and Yanming Xie

    Citation: BMC Complementary and Alternative Medicine 2017 17:108

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  12. Content type: Research article

    Acupuncture treatments that regulate the heart are used to treat various clinical disorders and conditions. Although many studies have been conducted to measure quantitatively the effects of acupuncture, thus ...

    Authors: Haebeom Lee, Hyunho Kim, Jungkuk Kim, Hwan-Sup Oh, Young-Jae Park and Young-Bae Park

    Citation: BMC Complementary and Alternative Medicine 2017 17:101

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  13. Content type: Research article

    Type two diabetes is a complex and demanding chronic disease and its impact in a state (Kerala) which leads India in terms of the number of people with Diabetes is profound. Though the male to female ratio amo...

    Authors: Aswathy Sreedevi, Unnikrishnan Ambika Gopalakrishnan, Sundaram Karimassery Ramaiyer and Leelamoni Kamalamma

    Citation: BMC Complementary and Alternative Medicine 2017 17:100

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  14. Content type: Research article

    Nutrition plays an important role in prevention and management of cardiovascular diseases (CVD) in early stages. Recent research demonstrated beneficial effects of various nutritional ingredients on vascular h...

    Authors: Claudia A. Reule, Birgit Goyvaerts and Christiane Schoen

    Citation: BMC Complementary and Alternative Medicine 2017 17:92

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  15. Content type: Research article

    Mind-body practices such as yoga have been studied for their generally positive effects on health-related quality of life (HRQOL). The association between how a person practices yoga and the person’s HRQOL is ...

    Authors: Gurjeet S. Birdee, Sujata G. Ayala and Kenneth A. Wallston

    Citation: BMC Complementary and Alternative Medicine 2017 17:83

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  16. Content type: Research article

    Many previous studies of electroacupuncture used combined therapy of electroacupuncture and systemic manual acupuncture, so it was uncertain which treatment was effective. This study evaluated and compared the...

    Authors: Bong Hyun Kim, Kyuseok Kim and Hae Jeong Nam

    Citation: BMC Complementary and Alternative Medicine 2017 17:85

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  17. Content type: Research article

    Several studies have used placebo acupuncture methods in recent years as a way for blinding therapeutic effect of acupuncture, however placebo method selection has not followed enough methodological criteria t...

    Authors: Leonardo Yung dos Santos Maciel, Paula Michele dos Santos Leite, Mauricio Lima Poderoso Neto, Andreza Carvalho Rabelo Mendonça, Carla Carolina Alves de Araujo, Jersica da Hora Santos Souza and Josimari Melo DeSantana

    Citation: BMC Complementary and Alternative Medicine 2016 16:518

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  18. Content type: Research article

    Electroacupuncture (EA), as an extension technique of acupuncture based on traditional acupuncture combined with modern electrotherapy, is commonly used for stroke in clinical treatment and researches. However...

    Authors: Jing-jing Wei, Wen-ting Yang, Su-bing Yin, Chen Wang, Yan Wang and Guo-qing Zheng

    Citation: BMC Complementary and Alternative Medicine 2016 16:512

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  19. Content type: Research article

    Ao-dake-humi is a traditional Japanese bamboo foot stimulator consisting of a half-pipe-shaped step made of bamboo used to stimulate the foot by stepping on it, and is commonly used to...

    Authors: Tomonori Minagawa, Tetsuichi Saitou, Toshiro Suzuki, Takahisa Domen, Hitoshi Yokoyama, Masakuni Ishikawa, Shiro Hirakata, Takashi Nagai, Masaki Nakazawa, Teruyuki Ogawa and Osamu Ishizuka

    Citation: BMC Complementary and Alternative Medicine 2016 16:513

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  20. Content type: Study protocol

    Prednisone plus azathioprine is considered the mainstay of therapy in the current recommendations for autoimmune hepatitis (AIH). However, it does not provide good benefits for AIH patients because of its seri...

    Authors: Xiao-ling Chi, Huan-ming Xiao, Yu-bao Xie, Gao-shu Cai, Jun-min Jiang, Guang-jun Tian, Mei-jie Shi, Shu-duo Wu, Peng-tao Zhao and Hui-jun Chen

    Citation: BMC Complementary and Alternative Medicine 2016 16:505

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  21. Content type: Research article

    In the author’s earlier in vitro investigation, a combination of 0.25 mg/ml green tea and 7.82 mg/ml Salvadora persica L. aqueous extracts was found to exhibit significant synergistic anti-bacterial and anti-adhe...

    Authors: Hayder Raad Abdulbaqi, Wan Harun Himratul-Aznita and Nor Adinar Baharuddin

    Citation: BMC Complementary and Alternative Medicine 2016 16:493

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  22. Content type: Research article

    Manual muscle testing (MMT) is a non-invasive assessment tool used by a variety of health care providers to evaluate neuromusculoskeletal integrity, and muscular strength in particular. In one form of MMT call...

    Authors: Anne M. Jensen, Richard J. Stevens and Amanda J. Burls

    Citation: BMC Complementary and Alternative Medicine 2016 16:492

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  23. Content type: Study protocol

    Coronary artery bypass graft surgery (CABG) is an effective and widespread coronary revascularisation technique, nevertheless there are a number of long-term postoperative complications from which patients can...

    Authors: Gert Roncada

    Citation: BMC Complementary and Alternative Medicine 2016 16:482

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  24. Content type: Research article

    Hashimoto’s thyroiditis is an autoimmune disorder and the most common cause of hypothyroidism. The use of Nigella sativa, a potent herbal medicine, continues to increase worldwide as an alternative treatment o...

    Authors: Mahdieh Abbasalizad Farhangi, Parvin Dehghan, Siroos Tajmiri and Mehran Mesgari Abbasi

    Citation: BMC Complementary and Alternative Medicine 2016 16:471

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  25. Content type: Research article

    The effect and safety of catgut implantation at acupoints o treat allergic rhinitis (ICD-10 code J30.4) remain controversial. Here, we used a sham catgut implantation group to determine whether catgut implanta...

    Authors: Xinrong Li, Yang Liu, Qinxiu Zhang, Nan Xiang, Miao He, Juan Zhong, Qing Chen and Xiaopei Wang

    Citation: BMC Complementary and Alternative Medicine 2016 16:454

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  26. Content type: Research article

    The theory of traditional Chinese medicine (TCM) constitution involves genetic characteristics, psychological factors, organ functions, and many other aspects. Studies have shown that TCM constitution is assoc...

    Authors: Yi Liu, Ting Pan, Wenjing Zou, Ye Sun, Yun Cai, Rui Wang, Pingping Han, Zhe Zhang, Qunying He and Feng Ye

    Citation: BMC Complementary and Alternative Medicine 2016 16:451

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  27. Content type: Research article

    Postoperative nausea and vomiting (PONV) is one of the most common postoperative complications of general anesthesia in pediatrics. Aromatherapy has been shown to be effective in treating PONV in adults. Given...

    Authors: Mathew B. Kiberd, Suzanne K. Clarke, Jill Chorney, Brandon d’Eon and Stuart Wright

    Citation: BMC Complementary and Alternative Medicine 2016 16:450

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  28. Content type: Research article

    Danlou tablets, a patented Chinese Medicine, have been long approved for the treatment of ischemic heart disease in China. While numerous empirical observations suggested Danlou tablets could decrease frequenc...

    Authors: Shuai Mao, Lei Wang, Wenwei Ouyang, Yuanshen Zhou, Jianyong Qi, Liheng Guo, Minzhou Zhang and Aleksander Hinek

    Citation: BMC Complementary and Alternative Medicine 2016 16:447

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  29. Content type: Study protocol

    Acupuncture is beneficial for controlling chemotherapy-induced nausea and vomiting (CINV). However, the effect of different acupoint combinations on controlling CINV remains unknown. This study aims to compare...

    Authors: Lili Gao, Bo Chen, Qiwen Zhang, Tianyi Zhao, Bo Li, Tao Sha, Jinxin Zou, Yongming Guo, Xingfang Pan and Yi Guo

    Citation: BMC Complementary and Alternative Medicine 2016 16:441

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  30. Content type: Study protocol

    Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) affects many adult men worldwide. The currently available therapies offer little or no proven benefit for CP/CPPS. We designed this study to assess th...

    Authors: Zongshi Qin, Zhiwei Zang, Jiani Wu, Jing Zhou and Zhishun Liu

    Citation: BMC Complementary and Alternative Medicine 2016 16:440

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  31. Content type: Research article

    Allergic rhinitis is regarded as an imbalanced Th1/Th2 cell-mediated response. The present study used microarray analysis to compare gene expression levels between allergic rhinitis patients before and after a...

    Authors: Horng-Sheng Shiue, Yun-Shien Lee, Chi-Neu Tsai and Hen-Hong Chang

    Citation: BMC Complementary and Alternative Medicine 2016 16:436

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  32. Content type: Study protocol

    Caregiving can be stressful, potentially creating physical and psychological strain. Substantial evidence has shown that family caregivers suffer from significant health problems arising from the demands of ca...

    Authors: Agnes Tiwari, Lixing Lao, Amy Xiao-Min Wang, Denise Shuk Ting Cheung, Mike Ka Pui So, Doris Sau Fung Yu, Terry Yat Sang Lum, Helina Yin King Yuk Fung, Jerry Wing Fai Yeung and Zhang-Jin Zhang

    Citation: BMC Complementary and Alternative Medicine 2016 16:424

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  33. Content type: Study protocol

    Irritable bowel syndrome (IBS) is a worldwide disease with high morbidity. The effect of current treatment with Western medicine is not satisfactory. Although moxibustion treatment is widely used for gastroint...

    Authors: Chunhui Bao, Jingzhi Zhang, Jinmei Liu, Huirong Liu, Luyi Wu, Yin Shi, Jing Li, Zhihai Hu, Yongzheng Dong, Siyao Wang, Xiaoqing Zeng and Huangan Wu

    Citation: BMC Complementary and Alternative Medicine 2016 16:408

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  34. Content type: Study protocol

    Virgin olive oil, a recognized healthy food, cannot be consumed in great quantities. We aim to assess in humans whether an optimized virgin olive oil with high phenolic content (OVOO, 429 mg/Kg) and a function...

    Authors: Sara Biel, Maria-Dolores Mesa, Rafael de la Torre, Juan-Antonio Espejo, Jose-Ramón Fernández-Navarro, Montserrat Fitó, Estefanía Sánchez-Rodriguez, Carmen Rosa, Rosa Marchal, Juan de Dios Alche, Manuela Expósito, Manuel Brenes, Beatriz Gandul, Miguel Angel Calleja and María-Isabel Covas

    Citation: BMC Complementary and Alternative Medicine 2016 16:404

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  35. Content type: Research article

    In Japanese Kampo medical practice, suidoku (fluid disturbance) is one of the most important concepts for selecting the proper medication. Suidoku is an excessive or uneven distribution of fluid that is indica...

    Authors: Aya Murakami, Daisuke Kobayashi, Toshio Kubota, Niina Zukeyama, Haru Mukae, Norihiro Furusyo, Mosaburo Kainuma and Takao Shimazoe

    Citation: BMC Complementary and Alternative Medicine 2016 16:405

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  36. Content type: Research article

    Blood-stasis syndrome (BSS) is one of the Traditional Chinese medicine (TCM) syndrome differentiations that are commonly seen in stroke and ischemic heart diseases; however, the BSS differentiation criterion i...

    Authors: Jiangquan Liao, Yongmei Liu and Jie Wang

    Citation: BMC Complementary and Alternative Medicine 2016 16:371

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    The Erratum to this article has been published in BMC Complementary and Alternative Medicine 2016 16:458

  37. Content type: Research article

    The primary objective of this study was to assess whether Zhengtian Capsule was non-inferior to flunarizine in efficacy and safety profile for prevention of migraine in adults.

    Authors: Kegang Cao, Fang Han, Anji Lin, Wenming Yang, Jianjun Zhao, Hui Zhang, Yanbing Ding, Wei Xie, Yinping Xu, Tingmin Yu, Xinzhi Wang, Xiaosu Yang, Jiying Zhou, Qun Hou, Lihua Yu and Ying Gao

    Citation: BMC Complementary and Alternative Medicine 2016 16:356

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  38. Content type: Research article

    Cerebral infarction frequently leads to mild cognitive impairment (MCI). Prompt management of MCI can prevent vascular dementia and improve patient outcome. This single center randomized controlled trial aims ...

    Authors: Shuhua Wang, Hongling Yang, Jie Zhang, Bin Zhang, Tao Liu, Lu Gan and Jiangang Zheng

    Citation: BMC Complementary and Alternative Medicine 2016 16:361

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  39. Content type: Research article

    Chinese traditional “eye exercises of acupoints” have been advocated as a compulsory measure to reduce visual symptoms, as well as to retard the development of refractive error, among Chinese students for deca...

    Authors: Zhong Lin, Balamurali Vasudevan, Su Jie Fang, Vishal Jhanji, Guang Yun Mao, Wei Han, Tie Ying Gao, Kenneth J. Ciuffreda and Yuan Bo Liang

    Citation: BMC Complementary and Alternative Medicine 2016 16:349

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  40. Content type: Research article

    Current clinical practices used to functionally classify heart failure (HF) are time-consuming, expensive, or require complex calculations. This study aimed to design an inquiry list from the perspective of tr...

    Authors: Tieh-Cheng Fu, Yi-Chung Lin, Ching-Mao Chang, Wei-Ling Chou, Pei-Hsun Yuan, Min-Hui Liu, Chao-Hung Wang, Juei-Chao Chen, Hen-Hong Chang and Tai-Long Pan

    Citation: BMC Complementary and Alternative Medicine 2016 16:342

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  41. Content type: Research article

    We aimed to evaluate the effect of an 8-week yoga intervention on the shoulder and spinal actions of women with breast cancer-related arm lymphoedema.

    Authors: Annette Loudon, Tony Barnett, Neil Piller, Maarten A. Immink, Denis Visentin and Andrew D. Williams

    Citation: BMC Complementary and Alternative Medicine 2016 16:343

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  42. Content type: Research article

    Virus-induced dendritic cells (DCs) functional deficiency leads to sub-optimal initiation of adaptive immune responses and consequently chronic infection establishment. The present study reports an advanced he...

    Authors: Doaa A. Ghareeb, Eiman H. Elwakeel, Rowaida Khalil, Mina S. Aziz and Maha A. El demellawy

    Citation: BMC Complementary and Alternative Medicine 2016 16:325

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  43. Content type: Research article

    Diabetes mellitus (DM) is a hypercoagulable state and is associated with highly increased risk of vascular complications. In the theory of traditional Chinese medicine (TCM), these vascular complications are c...

    Authors: Po-Chi Hsu, Yu-Chuen Huang, John Y. Chiang, Hen-Hong Chang, Pei-Yung Liao and Lun-Chien Lo

    Citation: BMC Complementary and Alternative Medicine 2016 16:324

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  44. Content type: Research article

    Antrodia cinnamomea (AC) is a popular medicinal mushroom in Taiwan that has been widely used for treatment of various cancers. Few clinical studies have reported its application and ef...

    Authors: Ming-Yen Tsai, Yu-Chiang Hung, Yen-Hao Chen, Yung-Hsiang Chen, Yu-Chuen Huang, Chao-Wei Kao, Yu-Li Su, Hsien-Hsueh Elley Chiu and Kun-Ming Rau

    Citation: BMC Complementary and Alternative Medicine 2016 16:322

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  45. Content type: Research article

    Self-report measures indicate that Yoga practices are perceived to reduce stress; however, molecular mechanisms through which YB affects stress are just beginning to be understood. While invasive sampling such...

    Authors: Waleed O. Twal, Amy E. Wahlquist and Sundaravadivel Balasubramanian

    Citation: BMC Complementary and Alternative Medicine 2016 16:294

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  46. Content type: Research article

    With an estimated 65 million Diabetes Mellitus (DM) patients, India ranks second in the world in terms of DM burden. The emphasis of current medical practice has been on pharmacotherapy but, despite the best c...

    Authors: Srinivas Bairy, Ajay M. V. Kumar, MSN Raju, Shanta Achanta, Balaji Naik, Jaya P. Tripathy and Rony Zachariah

    Citation: BMC Complementary and Alternative Medicine 2016 16:290

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  47. Content type: Research article

    Despite the increasing number and variety of antiepileptic drugs, nearly 30 % of epileptic patients who receive appropriate medical attention have persisting seizures. Anticonvulsant activity has been demonstr...

    Authors: Germain Sotoing Taiwe, Bernard Dabole, Thierry Bang Tchoya, Joseph Renaud Menanga, Paul Désiré Djomeni Dzeufiet and Michel De Waard

    Citation: BMC Complementary and Alternative Medicine 2016 16:285

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