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Clinical research

Edited by Holger Cramer, Jianping Liu and Karen Pilkington

This section covers research reporting clinical applications of interventions or resources in the complementary medicine field, including the evaluation of the efficacy and safety of the therapies, clinical trials and systematic reviews/meta-analysis.

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  1. Content type: Research article

    The first-line agents comprising antihistamines for chronic urticaria, are not completely satisfactory. Tripterygium wilfordii Hook F (TwHF), a Chinese herb, has been developed into several Tripterygium agents an...

    Authors: Liu Liu, Huaibo Zhao, Xiaoying Sun, Qi Zheng, Ying Luo, Yi Ru, Ying Zhang, Xi Chen, Bo Zhu, Chengqian Yin, Bin Li and Xin Li

    Citation: BMC Complementary and Alternative Medicine 2018 18:243

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  2. Content type: Research article

    Cancer-related anorexia remains one of the most prevalent and troublesome clinical problems experienced by patients with cancer during and after therapy. To ensure high-quality care, systematic reviews (SRs) a...

    Authors: Fangyuan Zhang, Aomei Shen, Yinghui Jin and Wanmin Qiang

    Citation: BMC Complementary and Alternative Medicine 2018 18:236

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  3. Content type: Study protocol

    Hypertension control remains a major global challenge. The behavioral approaches recommended for blood pressure reduction are stress reduction, increased exercise and healthy dietary habits. Some study finding...

    Authors: Raja Ram Dhungana, Mahesh Kumar Khanal, Suira Joshi, Om Prakash Kalauni, Anu Shakya, Vijay Bhrutel, Savyata Panthi, Ramesh Kumar KC, Binod Ghimire, Achyut Raj Pandey, Bihungum Bista, Binaya Sapkota, Shiva Ram Khatiwoda, Craig Steven McLachlan and Dinesh Neupane

    Citation: BMC Complementary and Alternative Medicine 2018 18:207

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  4. Content type: Research article

    We aimed to evaluate the effects of a hydroalcoholic extract of Juglans regia L. leaves on blood glucose level and cardiovascular risk factors in type 2 diabetic patients.

    Authors: Khadijeh Rabiei, Mohammad Ali Ebrahimzadeh, Majid Saeedi, Adele Bahar, Ozra Akha and Zahra Kashi

    Citation: BMC Complementary and Alternative Medicine 2018 18:206

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  5. Content type: Study protocol

    Uncomplicated urinary tract infections (UTI) are common in general practice and usually treated with antibiotics. This contributes to increasing resistance rates of uropathogenic bacteria. A previous trial sho...

    Authors: Kambiz Afshar, Nina Fleischmann, Guido Schmiemann, Jutta Bleidorn, Eva Hummers-Pradier, Tim Friede, Karl Wegscheider, Michael Moore and Ildikó Gágyor

    Citation: BMC Complementary and Alternative Medicine 2018 18:203

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  6. Content type: Research article

    Evidence suggests that tocotrienols may benefit bone health in osteopenic women. However, their safety in this population has never been investigated. This study was to evaluate the safety of a 12-week supplem...

    Authors: Chwan-Li Shen, Shu Wang, Shengping Yang, Michael D. Tomison, Mehrnaz Abbasi, Lei Hao, Sheyenne Scott, Md Shahjalal Khan, Amanda W. Romero, Carol K. Felton and Huanbiao Mo

    Citation: BMC Complementary and Alternative Medicine 2018 18:198

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  7. Content type: Research article

    The prevalence of functional constipation (FC) is 3–27%, and FC has been reported to cause discomfort in daily life and various complications. The treatment for FC depends on laxatives, and thus, effective and...

    Authors: Hye-Yoon Lee, Oh-Jin Kwon, Jung-Eun Kim, Mikyeong Kim, Ae-Ran Kim, Hyo-Ju Park, Jung-Hyo Cho, Joo-Hee Kim and Sun-Mi Choi

    Citation: BMC Complementary and Alternative Medicine 2018 18:186

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  8. Content type: Research article

    Patients entering a treatment have expectancy to outcome based on their previous experience, the information received, and the credibility of the treatment. Once the treatment has started, patients may detect ...

    Authors: Ingrid Liodden, Are Hugo Pripp and Arne Johan Norheim

    Citation: BMC Complementary and Alternative Medicine 2018 18:183

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  9. Content type: Research article

    Aromatase inhibitors reduce breast cancer recurrence rates in postmenopausal women by about 30% compared with tamoxifen while treatments differ. Unfortunately, nearly half of women taking AIs report AI-associa...

    Authors: Inmaculada Conejo, Bella Pajares, Emilio Alba and Antonio Ignacio Cuesta-Vargas

    Citation: BMC Complementary and Alternative Medicine 2018 18:180

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  10. Content type: Research article

    Advanced hepatobiliary cancers are highly lethal cancers that require precise prediction in clinical practice. Serum ferritin level increases in malignancy and high serum ferritin level is associated with poor...

    Authors: Anna Song, Wankyu Eo, Sehyun Kim, Bumsang Shim and Sookyung Lee

    Citation: BMC Complementary and Alternative Medicine 2018 18:176

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  11. Content type: Study protocol

    Knee Osteoarthritis (KOA) is a very common condition with prevalence rising with age. It is a major contributor to global disability and has a large socioeconomic burden worldwide. Conservative therapies have ...

    Authors: Regina Wing Shan Sit, Ricky Wing Keung Wu, Kenneth Dean Reeves, David Rabago, Dicken Cheong Chun Chan, Benjamin Hon Kei Yip, Vincent Chi Ho Chung and Samuel Yeung Shan Wong

    Citation: BMC Complementary and Alternative Medicine 2018 18:157

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  12. Content type: Research article

    Cancer patients often suffer from emotional distress as a result of the oncological process. The purpose of our study was to determine whether practice of Jacobson’s relaxation technique reduced consumption of...

    Authors: Paula Parás-Bravo, Cristina Alonso-Blanco, María Paz-Zulueta, Domingo Palacios-Ceña, Carmen María Sarabia-Cobo, Manuel Herrero-Montes, Ester Boixadera-Planas and César Fernández-de-las-Peñas

    Citation: BMC Complementary and Alternative Medicine 2018 18:139

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  13. Content type: Study protocol

    Sinew acupuncture is a new modality of acupuncture in which needles are inserted into acupoints, ashi points or spasm points of sinew and muscles along the meridian sinew pathway. A previous observational stud...

    Authors: Kwok Yin Au, Haiyong Chen, Wing Chung Lam, Chiu On Chong, Andrew Lau, Varut Vardhanabhuti, Kin Cheung Mak, Fei Jiang, Wing Yi Lam, Fung Man Wu, Hiu Ngok Chan, Yan Wah Ng, Bacon Fung-Leung Ng, Eric Tat-Chi Ziea and Lixing Lao

    Citation: BMC Complementary and Alternative Medicine 2018 18:133

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  14. Content type: Research article

    We aimed to investigate the effectiveness of two different forms of dry pulsatile cupping in patients with chronic low back pain (cLBP) compared to medication on demand only in a three-armed randomized trial.

    Authors: M. Teut, A. Ullmann, M. Ortiz, G. Rotter, S. Binting, M. Cree, F. Lotz, S. Roll and B. Brinkhaus

    Citation: BMC Complementary and Alternative Medicine 2018 18:115

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  15. Content type: Research article

    To evaluate the efficacy and tolerability of a poly-herbal formulation, Herbagut, for the treatment of gastrointestinal symptoms and its effect on quality of life parameters in patients presenting with self-re...

    Authors: Adrian L. Lopresti, Hemant Gupta and Stephen J. Smith

    Citation: BMC Complementary and Alternative Medicine 2018 18:98

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  16. Content type: Research article

    To explore if health related quality of life(HRQoL) increased after traditional yoga(TY), mindfulness based cognitive therapy(MBCT), or cognitive behavioral therapy(CBT), in patients on sick leave because of b...

    Authors: Astrid Grensman, Bikash Dev Acharya, Per Wändell, Gunnar H. Nilsson, Torkel Falkenberg, Örjan Sundin and Sigbritt Werner

    Citation: BMC Complementary and Alternative Medicine 2018 18:80

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  17. Content type: Research article

    Evidence suggests that fasting, during which only water is consumed, results in potentially health promoting physiological effects. However, peer-reviewed research assessing the safety of water-only fasting is...

    Authors: John S. Finnell, Bradley C. Saul, Alan C. Goldhamer and Toshia R. Myers

    Citation: BMC Complementary and Alternative Medicine 2018 18:67

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  18. Content type: Research article

    Depression is a common mental disorder. Chai Hu Shu Gan San, a traditional Chinese medicine, is used to treat depression empirically. We present a systematic review and meta-analysis of the therapeutic efficac...

    Authors: Yan Sun, Xia Xu, Jinping Zhang and Yuanyuan Chen

    Citation: BMC Complementary and Alternative Medicine 2018 18:66

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  19. Content type: Research article

    Although the efficiency of conservative management for lumbar spinal stenosis (LSS) has been examined, different conservative management approaches have not been compared. We have performed the first comparati...

    Authors: Hiroyuki Oka, Ko Matsudaira, Yuichi Takano, Daichi Kasuya, Masaki Niiya, Juichi Tonosu, Masayoshi Fukushima, Yasushi Oshima, Tomoko Fujii, Sakae Tanaka and Hirohiko Inanami

    Citation: BMC Complementary and Alternative Medicine 2018 18:19

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  20. Content type: Study protocol

    It has been suggested that the antioxidant, anti-inflammatory and hypolipidemic activities of cardamom may improve diabetes. However, the effect of this spice has not been investigated in diabetic subjects. Th...

    Authors: Mohadeseh Aghasi, Shohreh Ghazi-Zahedi, Fariba Koohdani, Fereydoun Siassi, Ensieh Nasli-Esfahani, Ali Keshavarz, Mostafa Qorbani, Hoorieh Khoshamal, Asma Salari-Moghaddam and Gity Sotoudeh

    Citation: BMC Complementary and Alternative Medicine 2018 18:18

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  21. Content type: Case report

    Impairment of cognitive function as well as negative symptom is the major factor causing the decline of a patient’s functioning in chronic stages of schizophrenia. However, until now, there were no definite tr...

    Authors: Seung Sun Rho, Young Sup Woo and Won-Myong Bahk

    Citation: BMC Complementary and Alternative Medicine 2018 18:14

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  22. Content type: Research article

    Unhealthy lifestyles are a major factor in the development and exacerbation of many chronic diseases. Improving lifestyles though immersive residential experiences that promote healthy behaviours is a focus of...

    Authors: Dhevaksha Naidoo, Adrian Schembri and Marc Cohen

    Citation: BMC Complementary and Alternative Medicine 2018 18:8

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  23. Content type: Research article

    The aim of this clinical trial was to assess the efficacy and safety of curcuminoid complex extract from turmeric rhizome with turmeric volatile oil (CuraMed®) and its combination with boswellic acid extract f...

    Authors: Armine Haroyan, Vahan Mukuchyan, Nana Mkrtchyan, Naira Minasyan, Srbuhi Gasparyan, Aida Sargsyan, Mikael Narimanyan and Areg Hovhannisyan

    Citation: BMC Complementary and Alternative Medicine 2018 18:7

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  24. Content type: Research article

    Clitoria ternatea L., a natural food-colorant containing anthocyanin, demonstrated antioxidant and antihyperglycemic activity. The aim of this study was to determine the effects of Clitoria ternatea flower extrac...

    Authors: Charoonsri Chusak, Thavaree Thilavech, Christiani Jeyakumar Henry and Sirichai Adisakwattana

    Citation: BMC Complementary and Alternative Medicine 2018 18:6

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  25. Content type: Research article

    Alzheimer’s disease (AD) is the most common cause of dementia. However, none of medical treatment can stop or reverse the underlying neurodegenerative of AD at present. Acupuncture has attracted more and more ...

    Authors: Yujie Jia, Xuezhu Zhang, Jianchun Yu, Jingxian Han, Tao Yu, Jiangwei Shi, Lan Zhao and Kun Nie

    Citation: BMC Complementary and Alternative Medicine 2017 17:556

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  26. Content type: Research article

    Osteopathic manipulative treatment (OMT) of the sphenopalatine ganglion (SPG) is used empirically for the treatment of rhinitis and snoring and is thought to increase pharyngeal stability. This trial was desig...

    Authors: Olivier Jacq, Isabelle Arnulf, Thomas Similowski and Valérie Attali

    Citation: BMC Complementary and Alternative Medicine 2017 17:546

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  27. Content type: Research article

    Conventional therapy (CT) such as donepezil and memantine are well-known short-term treatments for the symptoms of Alzheimer’s disease (AD). The efficacy of them, however, drops below baseline level after 9 mo...

    Authors: Jing Shi, Jingnian Ni, Tao Lu, Xuekai Zhang, Mingqing Wei, Ting Li, Weiwei Liu, Yongyan Wang, Yuanyuan Shi and Jinzhou Tian

    Citation: BMC Complementary and Alternative Medicine 2017 17:533

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  28. Content type: Research article

    Chinese herbal medicine formula Yu ping feng san (YPFS) is commonly used for allergic rhinitis (AR). Previous review had summarized the effectiveness and safety of YPFS, however without any subgroup analysis perf...

    Authors: Qiulan Luo, Claire Shuiqing Zhang, Lihong Yang, Anthony Lin Zhang, Xinfeng Guo, Charlie Changli Xue and Chuanjian Lu

    Citation: BMC Complementary and Alternative Medicine 2017 17:485

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  29. Content type: Research article

    Joint and connective tissue integrity, comfort and function are paramount to optimal performance in exercise, recreational and occupational activities. The fruit of Terminalia chebula has been used extensively in...

    Authors: H. L. Lopez, S. M. Habowski, J. E. Sandrock, B. Raub, A. Kedia, E. J. Bruno and T. N. Ziegenfuss

    Citation: BMC Complementary and Alternative Medicine 2017 17:475

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  30. Content type: Study protocol

    Although various treatments for breast cancer related lymphedema exist, there is still a need for a more effective and convenient approach. Pilot studies and our clinical observations suggested that acupunctur...

    Authors: Huiru Zhu, Jinwan Li, Zheng Peng, Yujie Huang, Xiaolan Lv, Liuying Song, Gechen Zhou, Shengzhang Lin, Jifei Chen, Baoyu He, Fengxian Qin, Xumexiang Liu, Meiyu Dai, Yan Zou and Shengming Dai

    Citation: BMC Complementary and Alternative Medicine 2017 17:467

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  31. Content type: Research article

    The beneficial effects of traditional herbs of Crete, Greece for the treatment of upper respiratory tract infections have been reported in observational and laboratory studies. Following a published, double bl...

    Authors: Marilena Anastasaki, Antonios Bertsias, Stergios A. Pirintsos, Elias Castanas and Christos Lionis

    Citation: BMC Complementary and Alternative Medicine 2017 17:466

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  32. Content type: Research article

    Most of the current anti-fungal treatments are chemical-based, fungistatic, have low efficacy in the treatment of tinea and toxicity concerns, while onychomycosis remains recalcitrant to most antifungal therap...

    Authors: Manoj Parekh, Girisha Ramaiah, Prachi Pashilkar, Ranjani Ramanujam, Peter Johnston and Leodevico L. Ilag

    Citation: BMC Complementary and Alternative Medicine 2017 17:464

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  33. Content type: Research article

    Mistletoe extracts have anti-tumor properties and are approved for subcutaneous use in cancer patients. Data on Intravenous application are limited.

    Authors: Roman Huber, Dietrich Schlodder, Carola Effertz, Sabine Rieger and Wilfried Tröger

    Citation: BMC Complementary and Alternative Medicine 2017 17:465

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  34. Content type: Research article

    Impaired glucose regulation (IGR) patients have increased risk of type 2 diabetes mellitus (T2DM). Identifying relevant risk factors in IGR subjects could facilitate early detection and prevention of IGR progr...

    Authors: Hong You, Tong Zhang, Wen Feng and Yun Gai

    Citation: BMC Complementary and Alternative Medicine 2017 17:459

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  35. Content type: Research article

    The objective of the current study was to assess the in vitro antiplasmodial activities of leaf, bark, flower, and the root of Pongamia pinnata against chloroquine-sensitive Plasmodium falciparum (3D7 strain), cy...

    Authors: P.V.V. Satish and K. Sunita

    Citation: BMC Complementary and Alternative Medicine 2017 17:458

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  36. Content type: Research article

    Approximately 11% of the German population are convinced that certain moon phases and moon signs may impact their health and the onset and clinical course of diseases. Before elective surgery, a considerable n...

    Authors: A. Kleespies, M. Mikhailov, P. N. Khalil, S. Pratschke, A. Khandoga, M. Stangl, W. D. Illner, M. K. Angele, K. W. Jauch, M. Guba, J. Werner and M. Rentsch

    Citation: BMC Complementary and Alternative Medicine 2017 17:440

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    The Correction to this article has been published in BMC Complementary and Alternative Medicine 2017 17:478

  37. Content type: Research article

    Indigo naturalis is a Traditional Chinese Medicine (TCM) ingredient long-recognized as a therapy for several inflammatory conditions, including psoriasis. However, its mechanism is unk...

    Authors: Hui-Man Cheng, Yang-Chang Wu, Qingmin Wang, Michael Song, Jackson Wu, Dion Chen, Katherine Li, Eric Wadman, Shung-Te Kao, Tsai-Chung Li, Francisco Leon, Karen Hayden, Carrie Brodmerkel and C. Chris Huang

    Citation: BMC Complementary and Alternative Medicine 2017 17:439

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  38. Content type: Research article

    Primary dysmenorrhoea (PD), defined as painful menses in women with normal pelvic anatomy, is one of the most common gynaecological syndromes. Acupoint-stimulation could potentially be an effective interventio...

    Authors: Yang Xu, Wenli Zhao, Te Li, Huaien Bu, Zhimei Zhao, Ye Zhao and Shilin Song

    Citation: BMC Complementary and Alternative Medicine 2017 17:436

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  39. Content type: Research article

    Feverfew (Tanacetum parthenium L.), magnesium and coenzyme Q10 are frequently used for migraine prophylaxis. Supplementation with a fixed combination of these three agents (Antemig®, PiLeJe) was investigated in a...

    Authors: Angèle Guilbot, Marie Bangratz, Samira Ait Abdellah and Christian Lucas

    Citation: BMC Complementary and Alternative Medicine 2017 17:433

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  40. Content type: Research article

    Use of complementary and alternative medicine (CAM) is widespread among different patient populations despite the availability of evidence-based conventional medicine and lack of supporting evidence for the cl...

    Authors: Mandreker Bahall

    Citation: BMC Complementary and Alternative Medicine 2017 17:422

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  41. Content type: Research article

    To achieve effective antiretroviral therapy (ART) outcomes, adherence to an antiretroviral regimen and a good immunometabolic response are essential. Food insecurity can act as a real barrier to adherence to b...

    Authors: Koy Tshingani, Philippe Donnen, Henri Mukumbi, Pierre Duez and Michèle Dramaix-Wilmet

    Citation: BMC Complementary and Alternative Medicine 2017 17:420

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  42. Content type: Research article

    Extracts from perna canaliculus, the Green Lipped Mussel (GLM) are widely used as a complimentary therapy by patients with osteoarthritis (OA). The current study investigated the potential of a novel GLM formulat...

    Authors: Simon Stebbings, Andrew Gray, Anthony G. Schneiders and Andrew Sansom

    Citation: BMC Complementary and Alternative Medicine 2017 17:416

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  43. Content type: Research article

    The purpose of the present study was to examine the body composition of So-Yang type males according to Sasang constitutional medicine, which is popular in Korea. Different Sasang constitutional types are asso...

    Authors: Jiwon Yoon, Jiho Nam, Chae Hun Leem and Jong Yeol Kim

    Citation: BMC Complementary and Alternative Medicine 2017 17:417

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  44. Content type: Study protocol

    Primary dysmenorrhea (PD) is one of the most common health complaints all over the world, specifically among young females. Acupuncture has been employed to relieve the pain-based symptoms and to avoid the sid...

    Authors: Yingfan Chen, Sinan Tian, Jing Tian and Shi Shu

    Citation: BMC Complementary and Alternative Medicine 2017 17:421

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  45. Content type: Research article

    Shinrin-yoku (experiencing the forest atmosphere or forest bathing) has received increasing attention from the perspective of preventive medicine in recent years. Some studies have rep...

    Authors: Yuki Ideno, Kunihiko Hayashi, Yukina Abe, Kayo Ueda, Hiroyasu Iso, Mitsuhiko Noda, Jung-Su Lee and Shosuke Suzuki

    Citation: BMC Complementary and Alternative Medicine 2017 17:409

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  46. Content type: Study protocol

    Bruxism is a repetitive activity that causes tooth wear, audible sounds, and discomfort. Preventive measures have been studied for conditions that can exert a negative influence on physiological development in...

    Authors: Mônica da Consolação Canuto Salgueiro, Carolina Carvalho Bortoletto, Anna Carolina RattoTempestini Horliana, Ana Carolina Costa Mota, Lara Jansiski Motta, Pamella de Barros Motta, Raquel Agnelli MesquitaFerrari, Kristianne Porta Santos Fernandes and Sandra Kalil Bussadori

    Citation: BMC Complementary and Alternative Medicine 2017 17:391

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  47. Content type: Study protocol

    Colorectal cancer imposes threats to patients’ well-being. Although most physical symptoms can be managed by medication, psychosocial stressors may complicate survival and hamper quality of life. Mindfulness a...

    Authors: Rainbow T. H. Ho, Adrian H. Y. Wan, Jessie S. M. Chan, S. M. Ng, K. F. Chung and Cecilia L. W. Chan

    Citation: BMC Complementary and Alternative Medicine 2017 17:390

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  48. Content type: Research article

    YY-312 is a herbal extract powder from Imperata cylindrica Beauvois, Citrus unshiu Markovich, and Evodia officinalis Dode, which have health promoting effects, including body fat reduction. We aimed to evaluate t...

    Authors: Young-Gyu Cho, Ji-Hye Jung, Jae-Heon Kang, Jin Soo Kwon, Seung Pil Yu and Tae Gon Baik

    Citation: BMC Complementary and Alternative Medicine 2017 17:375

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  49. Content type: Study protocol

    In the treatment of functional dyspepsia, the placebo effect has been reported to be high, and the influence of the patient-practitioner relationship may be a major component of this effect. The specific and n...

    Authors: Seok-Jae Ko, Jae-Woo Park, Jungtae Leem, Ted J. Kaptchuk, Vitaly Napadow, Braden Kuo, Jessica Gerber, Laurie Dimisko, Inkwon Yeo, Junhee Lee and Jinsung Kim

    Citation: BMC Complementary and Alternative Medicine 2017 17:363

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