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Clinical research

Edited by Holger Cramer, Jianping Liu and Karen Pilkington

This section covers research reporting clinical applications of interventions or resources in the complementary medicine field, including the evaluation of the efficacy and safety of the therapies, clinical trials and systematic reviews/meta-analysis.

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  1. Content type: Research article

    The prevalence of functional constipation (FC) is 3–27%, and FC has been reported to cause discomfort in daily life and various complications. The treatment for FC depends on laxatives, and thus, effective and...

    Authors: Hye-Yoon Lee, Oh-Jin Kwon, Jung-Eun Kim, Mikyeong Kim, Ae-Ran Kim, Hyo-Ju Park, Jung-Hyo Cho, Joo-Hee Kim and Sun-Mi Choi

    Citation: BMC Complementary and Alternative Medicine 2018 18:186

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  2. Content type: Research article

    Patients entering a treatment have expectancy to outcome based on their previous experience, the information received, and the credibility of the treatment. Once the treatment has started, patients may detect ...

    Authors: Ingrid Liodden, Are Hugo Pripp and Arne Johan Norheim

    Citation: BMC Complementary and Alternative Medicine 2018 18:183

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  3. Content type: Research article

    Aromatase inhibitors reduce breast cancer recurrence rates in postmenopausal women by about 30% compared with tamoxifen while treatments differ. Unfortunately, nearly half of women taking AIs report AI-associa...

    Authors: Inmaculada Conejo, Bella Pajares, Emilio Alba and Antonio Ignacio Cuesta-Vargas

    Citation: BMC Complementary and Alternative Medicine 2018 18:180

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  4. Content type: Research article

    Advanced hepatobiliary cancers are highly lethal cancers that require precise prediction in clinical practice. Serum ferritin level increases in malignancy and high serum ferritin level is associated with poor...

    Authors: Anna Song, Wankyu Eo, Sehyun Kim, Bumsang Shim and Sookyung Lee

    Citation: BMC Complementary and Alternative Medicine 2018 18:176

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  5. Content type: Study protocol

    Knee Osteoarthritis (KOA) is a very common condition with prevalence rising with age. It is a major contributor to global disability and has a large socioeconomic burden worldwide. Conservative therapies have ...

    Authors: Regina Wing Shan Sit, Ricky Wing Keung Wu, Kenneth Dean Reeves, David Rabago, Dicken Cheong Chun Chan, Benjamin Hon Kei Yip, Vincent Chi Ho Chung and Samuel Yeung Shan Wong

    Citation: BMC Complementary and Alternative Medicine 2018 18:157

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  6. Content type: Research article

    Cancer patients often suffer from emotional distress as a result of the oncological process. The purpose of our study was to determine whether practice of Jacobson’s relaxation technique reduced consumption of...

    Authors: Paula Parás-Bravo, Cristina Alonso-Blanco, María Paz-Zulueta, Domingo Palacios-Ceña, Carmen María Sarabia-Cobo, Manuel Herrero-Montes, Ester Boixadera-Planas and César Fernández-de-las-Peñas

    Citation: BMC Complementary and Alternative Medicine 2018 18:139

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  7. Content type: Study protocol

    Sinew acupuncture is a new modality of acupuncture in which needles are inserted into acupoints, ashi points or spasm points of sinew and muscles along the meridian sinew pathway. A previous observational stud...

    Authors: Kwok Yin Au, Haiyong Chen, Wing Chung Lam, Chiu On Chong, Andrew Lau, Varut Vardhanabhuti, Kin Cheung Mak, Fei Jiang, Wing Yi Lam, Fung Man Wu, Hiu Ngok Chan, Yan Wah Ng, Bacon Fung-Leung Ng, Eric Tat-Chi Ziea and Lixing Lao

    Citation: BMC Complementary and Alternative Medicine 2018 18:133

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  8. Content type: Research article

    We aimed to investigate the effectiveness of two different forms of dry pulsatile cupping in patients with chronic low back pain (cLBP) compared to medication on demand only in a three-armed randomized trial.

    Authors: M. Teut, A. Ullmann, M. Ortiz, G. Rotter, S. Binting, M. Cree, F. Lotz, S. Roll and B. Brinkhaus

    Citation: BMC Complementary and Alternative Medicine 2018 18:115

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  9. Content type: Research article

    To evaluate the efficacy and tolerability of a poly-herbal formulation, Herbagut, for the treatment of gastrointestinal symptoms and its effect on quality of life parameters in patients presenting with self-re...

    Authors: Adrian L. Lopresti, Hemant Gupta and Stephen J. Smith

    Citation: BMC Complementary and Alternative Medicine 2018 18:98

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  10. Content type: Research article

    To explore if health related quality of life(HRQoL) increased after traditional yoga(TY), mindfulness based cognitive therapy(MBCT), or cognitive behavioral therapy(CBT), in patients on sick leave because of b...

    Authors: Astrid Grensman, Bikash Dev Acharya, Per Wändell, Gunnar H. Nilsson, Torkel Falkenberg, Örjan Sundin and Sigbritt Werner

    Citation: BMC Complementary and Alternative Medicine 2018 18:80

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  11. Content type: Research article

    Evidence suggests that fasting, during which only water is consumed, results in potentially health promoting physiological effects. However, peer-reviewed research assessing the safety of water-only fasting is...

    Authors: John S. Finnell, Bradley C. Saul, Alan C. Goldhamer and Toshia R. Myers

    Citation: BMC Complementary and Alternative Medicine 2018 18:67

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  12. Content type: Research article

    Depression is a common mental disorder. Chai Hu Shu Gan San, a traditional Chinese medicine, is used to treat depression empirically. We present a systematic review and meta-analysis of the therapeutic efficac...

    Authors: Yan Sun, Xia Xu, Jinping Zhang and Yuanyuan Chen

    Citation: BMC Complementary and Alternative Medicine 2018 18:66

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  13. Content type: Research article

    Although the efficiency of conservative management for lumbar spinal stenosis (LSS) has been examined, different conservative management approaches have not been compared. We have performed the first comparati...

    Authors: Hiroyuki Oka, Ko Matsudaira, Yuichi Takano, Daichi Kasuya, Masaki Niiya, Juichi Tonosu, Masayoshi Fukushima, Yasushi Oshima, Tomoko Fujii, Sakae Tanaka and Hirohiko Inanami

    Citation: BMC Complementary and Alternative Medicine 2018 18:19

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  14. Content type: Study protocol

    It has been suggested that the antioxidant, anti-inflammatory and hypolipidemic activities of cardamom may improve diabetes. However, the effect of this spice has not been investigated in diabetic subjects. Th...

    Authors: Mohadeseh Aghasi, Shohreh Ghazi-Zahedi, Fariba Koohdani, Fereydoun Siassi, Ensieh Nasli-Esfahani, Ali Keshavarz, Mostafa Qorbani, Hoorieh Khoshamal, Asma Salari-Moghaddam and Gity Sotoudeh

    Citation: BMC Complementary and Alternative Medicine 2018 18:18

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  15. Content type: Case report

    Impairment of cognitive function as well as negative symptom is the major factor causing the decline of a patient’s functioning in chronic stages of schizophrenia. However, until now, there were no definite tr...

    Authors: Seung Sun Rho, Young Sup Woo and Won-Myong Bahk

    Citation: BMC Complementary and Alternative Medicine 2018 18:14

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  16. Content type: Research article

    Unhealthy lifestyles are a major factor in the development and exacerbation of many chronic diseases. Improving lifestyles though immersive residential experiences that promote healthy behaviours is a focus of...

    Authors: Dhevaksha Naidoo, Adrian Schembri and Marc Cohen

    Citation: BMC Complementary and Alternative Medicine 2018 18:8

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  17. Content type: Research article

    The aim of this clinical trial was to assess the efficacy and safety of curcuminoid complex extract from turmeric rhizome with turmeric volatile oil (CuraMed®) and its combination with boswellic acid extract f...

    Authors: Armine Haroyan, Vahan Mukuchyan, Nana Mkrtchyan, Naira Minasyan, Srbuhi Gasparyan, Aida Sargsyan, Mikael Narimanyan and Areg Hovhannisyan

    Citation: BMC Complementary and Alternative Medicine 2018 18:7

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  18. Content type: Research article

    Clitoria ternatea L., a natural food-colorant containing anthocyanin, demonstrated antioxidant and antihyperglycemic activity. The aim of this study was to determine the effects of Clitoria ternatea flower extrac...

    Authors: Charoonsri Chusak, Thavaree Thilavech, Christiani Jeyakumar Henry and Sirichai Adisakwattana

    Citation: BMC Complementary and Alternative Medicine 2018 18:6

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  19. Content type: Research article

    Alzheimer’s disease (AD) is the most common cause of dementia. However, none of medical treatment can stop or reverse the underlying neurodegenerative of AD at present. Acupuncture has attracted more and more ...

    Authors: Yujie Jia, Xuezhu Zhang, Jianchun Yu, Jingxian Han, Tao Yu, Jiangwei Shi, Lan Zhao and Kun Nie

    Citation: BMC Complementary and Alternative Medicine 2017 17:556

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  20. Content type: Research article

    Osteopathic manipulative treatment (OMT) of the sphenopalatine ganglion (SPG) is used empirically for the treatment of rhinitis and snoring and is thought to increase pharyngeal stability. This trial was desig...

    Authors: Olivier Jacq, Isabelle Arnulf, Thomas Similowski and Valérie Attali

    Citation: BMC Complementary and Alternative Medicine 2017 17:546

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