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Clinical research

Edited by Holger Cramer, Jianping Liu and Karen Pilkington

This section covers research reporting clinical applications of interventions or resources in the complementary medicine field, including the evaluation of the efficacy and safety of the therapies, clinical trials and systematic reviews/meta-analysis.

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  1. Content type: Research article

    Chinese herbal bath therapy (CHBT) is a traditional external therapy that has been used for the treatment of uremic pruritus (UP) in China. We conducted a meta-analysis to evaluate the efficacy and safety of C...

    Authors: Wenxuan Xue, Yanhua Zhao, Mengyun Yuan and Zhiqiang Zhao

    Citation: BMC Complementary and Alternative Medicine 2019 19:103

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  2. Content type: Research article

    Type 2 diabetes (T2D) is a global pandemic, and contributes significantly to the increasing incidence of conditions such as cardiovascular disease (CVD). Postprandial plasma glucose measured 2-h after the star...

    Authors: Ratheesh Mohan, Svenia Jose, Johannah Mulakkal, Darla Karpinsky-Semper, Andrew G. Swick and I. M. Krishnakumar

    Citation: BMC Complementary and Alternative Medicine 2019 19:99

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  3. Content type: Research article

    Endothelial dysfunction (ED) has been observed in individuals with metabolic syndrome (MetS) and contributes to the initiation and progression of atherosclerosis. The primary management of MetS involves lifest...

    Authors: Pingali Usharani, Padma Latha Merugu and Chandrasekhar Nutalapati

    Citation: BMC Complementary and Alternative Medicine 2019 19:97

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  4. Content type: Research article

    The purpose of this pilot study was to determine if a definitive clinical trial of thiamine supplementation was warranted in patients with acute heart failure. We hypothesized that thiamine, when added to stan...

    Authors: Howard A. Smithline, Michael Donnino, Fidela S. J. Blank, Richard Barus, Ryan A. Coute, Alexander B. Knee and Paul Visintainer

    Citation: BMC Complementary and Alternative Medicine 2019 19:96

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  5. Content type: Research article

    Whole-body electrical myostimulation (WB-EMS) is a relatively recent training methodology that has been extraordinarily used in recent years. However, there is a lack of consensus on the effectiveness of WB-EM...

    Authors: Alvaro Pano-Rodriguez, Jose Vicente Beltran-Garrido, Vicenç Hernández-González and Joaquim Reverter-Masia

    Citation: BMC Complementary and Alternative Medicine 2019 19:87

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  6. Content type: Case report

    Fructus Psoraleae is the seed of Psoralea corylifolia Linn. Fructus Psoraleae has been shown to be effective in treating some skin diseases, such as vitiligo. As a main ingredient in five types of herbs in the Qu...

    Authors: Ang Li, Minhong Gao, Na Zhao, Ping Li, Jinguo Zhu and Wenfei Li

    Citation: BMC Complementary and Alternative Medicine 2019 19:84

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  7. Content type: Research article

    Diabetic nephropathy (DN) is a common complication of diabetes mellitus (DM) that imposes an enormous burden on the healthcare system. Although some studies show that traditional Chinese medicine (TCM) treatme...

    Authors: Hsing-Yu Chen, Heng-Chih Pan, Yung-Chang Chen, Yu-Chun Chen, Yi-Hsuan Lin, Sien-Hung Yang, Jiun-Liang Chen and Hau-Tieng Wu

    Citation: BMC Complementary and Alternative Medicine 2019 19:81

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  8. Content type: Research article

    Cordyceps is a traditional Chinese herb that produces various biopharmaceutical effects, including immune-enhancing effects. In this study, we prepared a Cordyceps mycelium culture extract (Paecilomyces hepiali, ...

    Authors: Su-Jin Jung, Eun-Soo Jung, Eun-Kyung Choi, Hong-Sig Sin, Ki-Chan Ha and Soo-Wan Chae

    Citation: BMC Complementary and Alternative Medicine 2019 19:77

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  9. Content type: Research article

    Music has been shown to improve health and quality of life. It was suggested that music may also have an impact on gait stability and fall risk. Yet, few studies have exploited music in the hospital setting, a...

    Authors: Julia Chabot, Olivier Beauchet, Shek Fung and Isabelle Peretz

    Citation: BMC Complementary and Alternative Medicine 2019 19:76

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  10. Content type: Research article

    Influenza is a common viral infection worldwide. Maoto (ma-huang-tang) was developed in ancient China and is used to alleviate flu symptoms. Currently, no meta-analyses have evaluated the efficacy and safety of m...

    Authors: Tetsuhiro Yoshino, Ryutaro Arita, Yuko Horiba and Kenji Watanabe

    Citation: BMC Complementary and Alternative Medicine 2019 19:68

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  11. Content type: Research article

    Physical activity is an important part of the diabetes management plan. However, the effects caused by different training durations and styles of Tai Chi have not been evaluated. We conducted an updated system...

    Authors: Ting-Wei Xia, Yue Yang, Wei-Hong Li, Zhao-Hui Tang, Zong-Run Li and Li-Jun Qiao

    Citation: BMC Complementary and Alternative Medicine 2019 19:63

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  12. Content type: Research article

    This systematic review evaluates the use of manual therapy for clinical conditions in the pediatric population, assesses the methodological quality of the studies found, and synthesizes findings based on healt...

    Authors: Carol Parnell Prevost, Brian Gleberzon, Beth Carleo, Kristian Anderson, Morgan Cark and Katherine A. Pohlman

    Citation: BMC Complementary and Alternative Medicine 2019 19:60

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  13. Content type: Research article

    Despite the reported health effects of cardamom on dyslipidemia, hepatomegaly, and fasting hyperglycemia, no human research has studied its potency in non-alcoholic fatty liver disease (NAFLD) as the hepatic p...

    Authors: Milad Daneshi-Maskooni, Seyed Ali Keshavarz, Mostafa Qorbani, Siavash Mansouri, Seyed Moayed Alavian, Mahtab Badri-Fariman, Seyed Ali Jazayeri-Tehrani and Gity Sotoudeh

    Citation: BMC Complementary and Alternative Medicine 2019 19:59

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  14. Content type: Study protocol

    Practitioners of complementary and alternative medicine have suggested that acupuncture could alleviate poststroke shoulder pain, based on the clinical evidence. This study protocol is aimed at showing the eff...

    Authors: Seungwon Shin, Sung Pil Yang, Ami Yu, Junghee Yoo, Sung Min Lim and Euiju Lee

    Citation: BMC Complementary and Alternative Medicine 2019 19:58

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  15. Content type: Research article

    There are no published studies regarding the efficacy of traditional Chinese medicine (TCM) for the prevention of osteoporotic fracture. Therefore, we conducted this nationwide, population-based cohort study t...

    Authors: Yu-Chi Wang, Jen-Huai Chiang, Hsin-Cheng Hsu and Chun-Hao Tsai

    Citation: BMC Complementary and Alternative Medicine 2019 19:42

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  16. Content type: Research article

    Patients with cancer are vulnerable to depression or other depressive conditions. The aim of this paper was to evaluate the efficacy and safety of Chinese herbal medicine (CHM) for the treatment of depression ...

    Authors: Menglin Li, Zijie Chen, Zhenzhu Liu, Ning Zhang, Jintao Liu, Huiru Wang, Weiguang Wang, Yan Liang, Jingwen Chen, Zhe Liu, Yongle Li and Shuangqing Zhai

    Citation: BMC Complementary and Alternative Medicine 2019 19:28

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  17. Content type: Research article

    Dyslipidemia is one of the most frequently implicated risk factors for development of atherosclerosis. This study evaluated the efficacy of amla (Emblica officinalis) extract (composed of polyphenols, triterpenoi...

    Authors: Haridas Upadya, S. Prabhu, Aravinda Prasad, Deepa Subramanian, Swati Gupta and Ajay Goel

    Citation: BMC Complementary and Alternative Medicine 2019 19:27

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  18. Content type: Research article

    Menstrual pain is very common amongst young women. Despite the significant impact that menstrual pain has on academic attendance and performance, social activities and quality of life, most young women do not ...

    Authors: Mike Armour, Caroline A. Smith, Kylie A. Steel and Freya Macmillan

    Citation: BMC Complementary and Alternative Medicine 2019 19:22

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  19. Content type: Research article

    Peppermint oil (PO) has intrinsic properties that may benefit patients with irritable bowel syndrome (IBS) symptoms. The study objective was to determine the effect of peppermint oil in the treatment of the IBS.

    Authors: N. Alammar, L. Wang, B. Saberi, J. Nanavati, G. Holtmann, R. T. Shinohara and G. E. Mullin

    Citation: BMC Complementary and Alternative Medicine 2019 19:21

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  20. Content type: Research article

    Almost half of mild cognitive impairment (MCI) patients progress to dementia, which is associated with decreased quality of life and obstacles to independent living. Relevant management is expected to prevent ...

    Authors: Hwan Kim, Hong Kyoung Kim, Si Yeon Kim, Young Il Kim, Ho Ryong Yoo and In Chul Jung

    Citation: BMC Complementary and Alternative Medicine 2019 19:13

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  21. Content type: Research article

    Patients with rheumatoid arthritis (RA) have a higher risk of coronary heart disease (CHD). Acupuncture, a commonly used treatment for patients with RA, has not been reported to prevent CHD in patients with RA...

    Authors: Mei-Yao Wu, Ming-Cheng Huang, Hou-Hsun Liao, Jen-Huai Chiang, Yu-Chen Lee, Chung-Y Hsu, Mao-Feng Sun and Hung-Rong Yen

    Citation: BMC Complementary and Alternative Medicine 2018 18:341

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  22. Content type: Research article

    (Trans)-3,7-Dimethyl-2,6-octadien-1-ol, commonly called geraniol (Ge-OH), is an acyclic monoterpene alcohol with well-known anti-inflammatory and antimicrobial properties. Ge-OH is a non-toxic compound classif...

    Authors: Fernando Rizzello, Chiara Ricci, Michela Scandella, Elena Cavazza, Elisabetta Giovanardi, Maria Chiara Valerii, Massimo Campieri, Antonietta Comparone, Luigia De Fazio, Marco Candela, Silvia Turroni and Enzo Spisni

    Citation: BMC Complementary and Alternative Medicine 2018 18:338

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  23. Content type: Research article

    Little is studied about complications related to probiotic ingestion. This study proposes to present a synthesis and critical evaluation of the reports and series of cases on the infectious complications relat...

    Authors: Rafael Lessa Costa, José Moreira, Andrea Lorenzo and Cristiane C. Lamas

    Citation: BMC Complementary and Alternative Medicine 2018 18:329

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  24. Content type: Research article

    One of the most common orthopedic problems is the incidence of pressure ulcer followed by immobility. This study aimed to investigate the effect of Aloe Vera gel on the prevention of pressure ulcer in patients ho...

    Authors: Davood Hekmatpou, Fatemeh Mehrabi, Kobra Rahzani and Atefeh Aminiyan

    Citation: BMC Complementary and Alternative Medicine 2018 18:264

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  25. Content type: Research article

    Due to limitations of conventional medicine for atopic eczema (AE), complementary and alternative medicine (CAM) is widely used as an alternative, maintaining, or simultaneous treatment for AE. We aimed to eva...

    Authors: Chun-li Lu, Xue-han Liu, Trine Stub, Agnete E. Kristoffersen, Shi-bing Liang, Xiao Wang, Xue Bai, Arne Johan Norheim, Frauke Musial, Terje Araek, Vinjar Fonnebo and Jian-ping Liu

    Citation: BMC Complementary and Alternative Medicine 2018 18:260

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    The Correction to this article has been published in BMC Complementary and Alternative Medicine 2019 19:16

  26. Content type: Research article

    The first-line agents comprising antihistamines for chronic urticaria, are not completely satisfactory. Tripterygium wilfordii Hook F (TwHF), a Chinese herb, has been developed into several Tripterygium agents an...

    Authors: Liu Liu, Huaibo Zhao, Xiaoying Sun, Qi Zheng, Ying Luo, Yi Ru, Ying Zhang, Xi Chen, Bo Zhu, Chengqian Yin, Bin Li and Xin Li

    Citation: BMC Complementary and Alternative Medicine 2018 18:243

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  27. Content type: Research article

    Cancer-related anorexia remains one of the most prevalent and troublesome clinical problems experienced by patients with cancer during and after therapy. To ensure high-quality care, systematic reviews (SRs) a...

    Authors: Fangyuan Zhang, Aomei Shen, Yinghui Jin and Wanmin Qiang

    Citation: BMC Complementary and Alternative Medicine 2018 18:236

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  28. Content type: Study protocol

    Hypertension control remains a major global challenge. The behavioral approaches recommended for blood pressure reduction are stress reduction, increased exercise and healthy dietary habits. Some study finding...

    Authors: Raja Ram Dhungana, Mahesh Kumar Khanal, Suira Joshi, Om Prakash Kalauni, Anu Shakya, Vijay Bhrutel, Savyata Panthi, Ramesh Kumar KC, Binod Ghimire, Achyut Raj Pandey, Bihungum Bista, Binaya Sapkota, Shiva Ram Khatiwoda, Craig Steven McLachlan and Dinesh Neupane

    Citation: BMC Complementary and Alternative Medicine 2018 18:207

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  29. Content type: Research article

    We aimed to evaluate the effects of a hydroalcoholic extract of Juglans regia L. leaves on blood glucose level and cardiovascular risk factors in type 2 diabetic patients.

    Authors: Khadijeh Rabiei, Mohammad Ali Ebrahimzadeh, Majid Saeedi, Adele Bahar, Ozra Akha and Zahra Kashi

    Citation: BMC Complementary and Alternative Medicine 2018 18:206

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  30. Content type: Study protocol

    Uncomplicated urinary tract infections (UTI) are common in general practice and usually treated with antibiotics. This contributes to increasing resistance rates of uropathogenic bacteria. A previous trial sho...

    Authors: Kambiz Afshar, Nina Fleischmann, Guido Schmiemann, Jutta Bleidorn, Eva Hummers-Pradier, Tim Friede, Karl Wegscheider, Michael Moore and Ildikó Gágyor

    Citation: BMC Complementary and Alternative Medicine 2018 18:203

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  31. Content type: Research article

    Evidence suggests that tocotrienols may benefit bone health in osteopenic women. However, their safety in this population has never been investigated. This study was to evaluate the safety of a 12-week supplem...

    Authors: Chwan-Li Shen, Shu Wang, Shengping Yang, Michael D. Tomison, Mehrnaz Abbasi, Lei Hao, Sheyenne Scott, Md Shahjalal Khan, Amanda W. Romero, Carol K. Felton and Huanbiao Mo

    Citation: BMC Complementary and Alternative Medicine 2018 18:198

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  32. Content type: Research article

    The prevalence of functional constipation (FC) is 3–27%, and FC has been reported to cause discomfort in daily life and various complications. The treatment for FC depends on laxatives, and thus, effective and...

    Authors: Hye-Yoon Lee, Oh-Jin Kwon, Jung-Eun Kim, Mikyeong Kim, Ae-Ran Kim, Hyo-Ju Park, Jung-Hyo Cho, Joo-Hee Kim and Sun-Mi Choi

    Citation: BMC Complementary and Alternative Medicine 2018 18:186

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  33. Content type: Research article

    Patients entering a treatment have expectancy to outcome based on their previous experience, the information received, and the credibility of the treatment. Once the treatment has started, patients may detect ...

    Authors: Ingrid Liodden, Are Hugo Pripp and Arne Johan Norheim

    Citation: BMC Complementary and Alternative Medicine 2018 18:183

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  34. Content type: Research article

    Aromatase inhibitors reduce breast cancer recurrence rates in postmenopausal women by about 30% compared with tamoxifen while treatments differ. Unfortunately, nearly half of women taking AIs report AI-associa...

    Authors: Inmaculada Conejo, Bella Pajares, Emilio Alba and Antonio Ignacio Cuesta-Vargas

    Citation: BMC Complementary and Alternative Medicine 2018 18:180

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  35. Content type: Research article

    Advanced hepatobiliary cancers are highly lethal cancers that require precise prediction in clinical practice. Serum ferritin level increases in malignancy and high serum ferritin level is associated with poor...

    Authors: Anna Song, Wankyu Eo, Sehyun Kim, Bumsang Shim and Sookyung Lee

    Citation: BMC Complementary and Alternative Medicine 2018 18:176

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  36. Content type: Study protocol

    Knee Osteoarthritis (KOA) is a very common condition with prevalence rising with age. It is a major contributor to global disability and has a large socioeconomic burden worldwide. Conservative therapies have ...

    Authors: Regina Wing Shan Sit, Ricky Wing Keung Wu, Kenneth Dean Reeves, David Rabago, Dicken Cheong Chun Chan, Benjamin Hon Kei Yip, Vincent Chi Ho Chung and Samuel Yeung Shan Wong

    Citation: BMC Complementary and Alternative Medicine 2018 18:157

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  37. Content type: Research article

    Cancer patients often suffer from emotional distress as a result of the oncological process. The purpose of our study was to determine whether practice of Jacobson’s relaxation technique reduced consumption of...

    Authors: Paula Parás-Bravo, Cristina Alonso-Blanco, María Paz-Zulueta, Domingo Palacios-Ceña, Carmen María Sarabia-Cobo, Manuel Herrero-Montes, Ester Boixadera-Planas and César Fernández-de-las-Peñas

    Citation: BMC Complementary and Alternative Medicine 2018 18:139

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  38. Content type: Study protocol

    Sinew acupuncture is a new modality of acupuncture in which needles are inserted into acupoints, ashi points or spasm points of sinew and muscles along the meridian sinew pathway. A previous observational stud...

    Authors: Kwok Yin Au, Haiyong Chen, Wing Chung Lam, Chiu On Chong, Andrew Lau, Varut Vardhanabhuti, Kin Cheung Mak, Fei Jiang, Wing Yi Lam, Fung Man Wu, Hiu Ngok Chan, Yan Wah Ng, Bacon Fung-Leung Ng, Eric Tat-Chi Ziea and Lixing Lao

    Citation: BMC Complementary and Alternative Medicine 2018 18:133

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  39. Content type: Research article

    We aimed to investigate the effectiveness of two different forms of dry pulsatile cupping in patients with chronic low back pain (cLBP) compared to medication on demand only in a three-armed randomized trial.

    Authors: M. Teut, A. Ullmann, M. Ortiz, G. Rotter, S. Binting, M. Cree, F. Lotz, S. Roll and B. Brinkhaus

    Citation: BMC Complementary and Alternative Medicine 2018 18:115

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  40. Content type: Research article

    To evaluate the efficacy and tolerability of a poly-herbal formulation, Herbagut, for the treatment of gastrointestinal symptoms and its effect on quality of life parameters in patients presenting with self-re...

    Authors: Adrian L. Lopresti, Hemant Gupta and Stephen J. Smith

    Citation: BMC Complementary and Alternative Medicine 2018 18:98

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  41. Content type: Research article

    To explore if health related quality of life(HRQoL) increased after traditional yoga(TY), mindfulness based cognitive therapy(MBCT), or cognitive behavioral therapy(CBT), in patients on sick leave because of b...

    Authors: Astrid Grensman, Bikash Dev Acharya, Per Wändell, Gunnar H. Nilsson, Torkel Falkenberg, Örjan Sundin and Sigbritt Werner

    Citation: BMC Complementary and Alternative Medicine 2018 18:80

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  42. Content type: Research article

    Evidence suggests that fasting, during which only water is consumed, results in potentially health promoting physiological effects. However, peer-reviewed research assessing the safety of water-only fasting is...

    Authors: John S. Finnell, Bradley C. Saul, Alan C. Goldhamer and Toshia R. Myers

    Citation: BMC Complementary and Alternative Medicine 2018 18:67

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  43. Content type: Research article

    Depression is a common mental disorder. Chai Hu Shu Gan San, a traditional Chinese medicine, is used to treat depression empirically. We present a systematic review and meta-analysis of the therapeutic efficac...

    Authors: Yan Sun, Xia Xu, Jinping Zhang and Yuanyuan Chen

    Citation: BMC Complementary and Alternative Medicine 2018 18:66

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  44. Content type: Research article

    Although the efficiency of conservative management for lumbar spinal stenosis (LSS) has been examined, different conservative management approaches have not been compared. We have performed the first comparati...

    Authors: Hiroyuki Oka, Ko Matsudaira, Yuichi Takano, Daichi Kasuya, Masaki Niiya, Juichi Tonosu, Masayoshi Fukushima, Yasushi Oshima, Tomoko Fujii, Sakae Tanaka and Hirohiko Inanami

    Citation: BMC Complementary and Alternative Medicine 2018 18:19

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  45. Content type: Study protocol

    It has been suggested that the antioxidant, anti-inflammatory and hypolipidemic activities of cardamom may improve diabetes. However, the effect of this spice has not been investigated in diabetic subjects. Th...

    Authors: Mohadeseh Aghasi, Shohreh Ghazi-Zahedi, Fariba Koohdani, Fereydoun Siassi, Ensieh Nasli-Esfahani, Ali Keshavarz, Mostafa Qorbani, Hoorieh Khoshamal, Asma Salari-Moghaddam and Gity Sotoudeh

    Citation: BMC Complementary and Alternative Medicine 2018 18:18

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  46. Content type: Case report

    Impairment of cognitive function as well as negative symptom is the major factor causing the decline of a patient’s functioning in chronic stages of schizophrenia. However, until now, there were no definite tr...

    Authors: Seung Sun Rho, Young Sup Woo and Won-Myong Bahk

    Citation: BMC Complementary and Alternative Medicine 2018 18:14

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  47. Content type: Research article

    Unhealthy lifestyles are a major factor in the development and exacerbation of many chronic diseases. Improving lifestyles though immersive residential experiences that promote healthy behaviours is a focus of...

    Authors: Dhevaksha Naidoo, Adrian Schembri and Marc Cohen

    Citation: BMC Complementary and Alternative Medicine 2018 18:8

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  48. Content type: Research article

    The aim of this clinical trial was to assess the efficacy and safety of curcuminoid complex extract from turmeric rhizome with turmeric volatile oil (CuraMed®) and its combination with boswellic acid extract f...

    Authors: Armine Haroyan, Vahan Mukuchyan, Nana Mkrtchyan, Naira Minasyan, Srbuhi Gasparyan, Aida Sargsyan, Mikael Narimanyan and Areg Hovhannisyan

    Citation: BMC Complementary and Alternative Medicine 2018 18:7

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