Clinical research

Edited by Jianping Liu

This section covers research reporting clinical applications of interventions or resources in the complementary medicine field, including the evaluation of the efficacy and safety of the therapies, clinical trials and systematic reviews/meta-analysis.

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  1. Research article

    Effects of dietary supplementation with a standardized aqueous extract of Terminalia chebula fruit (AyuFlex®) on joint mobility, comfort, and functional capacity in healthy overweight subjects: a randomized placebo-controlled clinical trial

    Joint and connective tissue integrity, comfort and function are paramount to optimal performance in exercise, recreational and occupational activities. The fruit of Terminalia chebula has been used extensively in...

    H. L. Lopez, S. M. Habowski, J. E. Sandrock, B. Raub, A. Kedia, E. J. Bruno and T. N. Ziegenfuss

    BMC Complementary and Alternative Medicine 2017 17:475

    Published on: 2 October 2017

  2. Study protocol

    Effectiveness of acupuncture for breast cancer related lymphedema: protocol for a single-blind, sham-controlled, randomized, multicenter trial

    Although various treatments for breast cancer related lymphedema exist, there is still a need for a more effective and convenient approach. Pilot studies and our clinical observations suggested that acupunctur...

    Huiru Zhu, Jinwan Li, Zheng Peng, Yujie Huang, Xiaolan Lv, Liuying Song, Gechen Zhou, Shengzhang Lin, Jifei Chen, Baoyu He, Fengxian Qin, Xumexiang Liu, Meiyu Dai, Yan Zou and Shengming Dai

    BMC Complementary and Alternative Medicine 2017 17:467

    Published on: 21 September 2017

  3. Research article

    Post-market outcome of an extract of traditional Cretan herbs on upper respiratory tract infections: a pragmatic, prospective observational study

    The beneficial effects of traditional herbs of Crete, Greece for the treatment of upper respiratory tract infections have been reported in observational and laboratory studies. Following a published, double bl...

    Marilena Anastasaki, Antonios Bertsias, Stergios A. Pirintsos, Elias Castanas and Christos Lionis

    BMC Complementary and Alternative Medicine 2017 17:466

    Published on: 21 September 2017

  4. Research article

    A pilot single centre, double blind, placebo controlled, randomized, parallel study of Calmagen® dermaceutical cream and lotion for the topical treatment of tinea and onychomycosis

    Most of the current anti-fungal treatments are chemical-based, fungistatic, have low efficacy in the treatment of tinea and toxicity concerns, while onychomycosis remains recalcitrant to most antifungal therap...

    Manoj Parekh, Girisha Ramaiah, Prachi Pashilkar, Ranjani Ramanujam, Peter Johnston and Leodevico L. Ilag

    BMC Complementary and Alternative Medicine 2017 17:464

    Published on: 18 September 2017

  5. Research article

    Moon phases and moon signs do not influence morbidity, mortality and long-term survival, after living donor kidney transplantation

    Approximately 11% of the German population are convinced that certain moon phases and moon signs may impact their health and the onset and clinical course of diseases. Before elective surgery, a considerable n...

    A. Kleespies, M. Mikhailov, P. N. Khalil, S. Pratschke, A. Khandoga, M. Stangl, W. D. Illner, M. K. Angele, K. W. Jauch, M. Guba, J. Werner and M. Rentsch

    BMC Complementary and Alternative Medicine 2017 17:440

    Published on: 4 September 2017

    The Correction to this article has been published in BMC Complementary and Alternative Medicine 2017 17:478

  6. Research article

    Clinical efficacy and IL-17 targeting mechanism of Indigo naturalis as a topical agent in moderate psoriasis

    Indigo naturalis is a Traditional Chinese Medicine (TCM) ingredient long-recognized as a therapy for several inflammatory conditions, including psoriasis. However, its mechanism is unk...

    Hui-Man Cheng, Yang-Chang Wu, Qingmin Wang, Michael Song, Jackson Wu, Dion Chen, Katherine Li, Eric Wadman, Shung-Te Kao, Tsai-Chung Li, Francisco Leon, Karen Hayden, Carrie Brodmerkel and C. Chris Huang

    BMC Complementary and Alternative Medicine 2017 17:439

    Published on: 2 September 2017

  7. Research article

    Effects of acupoint-stimulation for the treatment of primary dysmenorrhoea compared with NSAIDs: a systematic review and meta-analysis of 19 RCTs

    Primary dysmenorrhoea (PD), defined as painful menses in women with normal pelvic anatomy, is one of the most common gynaecological syndromes. Acupoint-stimulation could potentially be an effective interventio...

    Yang Xu, Wenli Zhao, Te Li, Huaien Bu, Zhimei Zhao, Ye Zhao and Shilin Song

    BMC Complementary and Alternative Medicine 2017 17:436

    Published on: 31 August 2017

  8. Research article

    A combination of coenzyme Q10, feverfew and magnesium for migraine prophylaxis: a prospective observational study

    Feverfew (Tanacetum parthenium L.), magnesium and coenzyme Q10 are frequently used for migraine prophylaxis. Supplementation with a fixed combination of these three agents (Antemig®, PiLeJe) was investigated in a...

    Angèle Guilbot, Marie Bangratz, Samira Ait Abdellah and Christian Lucas

    BMC Complementary and Alternative Medicine 2017 17:433

    Published on: 30 August 2017

  9. Research article

    Impact of Moringa oleifera lam. Leaf powder supplementation versus nutritional counseling on the body mass index and immune response of HIV patients on antiretroviral therapy: a single-blind randomized control trial

    To achieve effective antiretroviral therapy (ART) outcomes, adherence to an antiretroviral regimen and a good immunometabolic response are essential. Food insecurity can act as a real barrier to adherence to b...

    Koy Tshingani, Philippe Donnen, Henri Mukumbi, Pierre Duez and Michèle Dramaix-Wilmet

    BMC Complementary and Alternative Medicine 2017 17:420

    Published on: 22 August 2017

  10. Research article

    A randomized double-blind placebo-controlled trial to investigate the effectiveness and safety of a novel green-lipped mussel extract -BioLex® -for managing pain in moderate to severe osteoarthritis of the hip and knee

    Extracts from perna canaliculus, the Green Lipped Mussel (GLM) are widely used as a complimentary therapy by patients with osteoarthritis (OA). The current study investigated the potential of a novel GLM formulat...

    Simon Stebbings, Andrew Gray, Anthony G. Schneiders and Andrew Sansom

    BMC Complementary and Alternative Medicine 2017 17:416

    Published on: 22 August 2017

  11. Research article

    Body composition and personality traits in so-Yang type males

    The purpose of the present study was to examine the body composition of So-Yang type males according to Sasang constitutional medicine, which is popular in Korea. Different Sasang constitutional types are asso...

    Jiwon Yoon, Jiho Nam, Chae Hun Leem and Jong Yeol Kim

    BMC Complementary and Alternative Medicine 2017 17:417

    Published on: 22 August 2017

  12. Study protocol

    Wrist-ankle acupuncture (WAA) for primary dysmenorrhea (PD) of young females: study protocol for a randomized controlled trial

    Primary dysmenorrhea (PD) is one of the most common health complaints all over the world, specifically among young females. Acupuncture has been employed to relieve the pain-based symptoms and to avoid the sid...

    Yingfan Chen, Sinan Tian, Jing Tian and Shi Shu

    BMC Complementary and Alternative Medicine 2017 17:421

    Published on: 22 August 2017

  13. Research article

    Blood pressure-lowering effect of Shinrin-yoku (Forest bathing): a systematic review and meta-analysis

    Shinrin-yoku (experiencing the forest atmosphere or forest bathing) has received increasing attention from the perspective of preventive medicine in recent years. Some studies have rep...

    Yuki Ideno, Kunihiko Hayashi, Yukina Abe, Kayo Ueda, Hiroyasu Iso, Mitsuhiko Noda, Jung-Su Lee and Shosuke Suzuki

    BMC Complementary and Alternative Medicine 2017 17:409

    Published on: 16 August 2017

  14. Study protocol

    Evaluation of muscle activity, bite force and salivary cortisol in children with bruxism before and after low level laser applied to acupoints: study protocol for a randomised controlled trial

    Bruxism is a repetitive activity that causes tooth wear, audible sounds, and discomfort. Preventive measures have been studied for conditions that can exert a negative influence on physiological development in...

    Mônica da Consolação Canuto Salgueiro, Carolina Carvalho Bortoletto, Anna Carolina RattoTempestini Horliana, Ana Carolina Costa Mota, Lara Jansiski Motta, Pamella de Barros Motta, Raquel Agnelli MesquitaFerrari, Kristianne Porta Santos Fernandes and Sandra Kalil Bussadori

    BMC Complementary and Alternative Medicine 2017 17:391

    Published on: 8 August 2017

  15. Study protocol

    Study protocol on comparative effectiveness of mindfulness meditation and qigong on psychophysiological outcomes for patients with colorectal cancer: a randomized controlled trial

    Colorectal cancer imposes threats to patients’ well-being. Although most physical symptoms can be managed by medication, psychosocial stressors may complicate survival and hamper quality of life. Mindfulness a...

    Rainbow T. H. Ho, Adrian H. Y. Wan, Jessie S. M. Chan, S. M. Ng, K. F. Chung and Cecilia L. W. Chan

    BMC Complementary and Alternative Medicine 2017 17:390

    Published on: 8 August 2017

  16. Research article

    Effect of a herbal extract powder (YY-312) from Imperata cylindrica Beauvois, Citrus unshiu Markovich, and Evodia officinalis Dode on body fat mass in overweight adults: a 12-week, randomized, double-blind, placebo-controlled, parallel-group clinical trial

    YY-312 is a herbal extract powder from Imperata cylindrica Beauvois, Citrus unshiu Markovich, and Evodia officinalis Dode, which have health promoting effects, including body fat reduction. We aimed to evaluate t...

    Young-Gyu Cho, Ji-Hye Jung, Jae-Heon Kang, Jin Soo Kwon, Seung Pil Yu and Tae Gon Baik

    BMC Complementary and Alternative Medicine 2017 17:375

    Published on: 28 July 2017

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