Clinical research

Edited by Jianping Liu

This section covers research reporting clinical applications of interventions or resources in the complementary medicine field, including the evaluation of the efficacy and safety of the therapies, clinical trials and systematic reviews/meta-analysis.

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  1. Research article

    Blood pressure-lowering effect of Shinrin-yoku (Forest bathing): a systematic review and meta-analysis

    Shinrin-yoku (experiencing the forest atmosphere or forest bathing) has received increasing attention from the perspective of preventive medicine in recent years. Some studies have rep...

    Yuki Ideno, Kunihiko Hayashi, Yukina Abe, Kayo Ueda, Hiroyasu Iso, Mitsuhiko Noda, Jung-Su Lee and Shosuke Suzuki

    BMC Complementary and Alternative Medicine 2017 17:409

    Published on: 16 August 2017

  2. Study protocol

    Evaluation of muscle activity, bite force and salivary cortisol in children with bruxism before and after low level laser applied to acupoints: study protocol for a randomised controlled trial

    Bruxism is a repetitive activity that causes tooth wear, audible sounds, and discomfort. Preventive measures have been studied for conditions that can exert a negative influence on physiological development in...

    Mônica da Consolação Canuto Salgueiro, Carolina Carvalho Bortoletto, Anna Carolina RattoTempestini Horliana, Ana Carolina Costa Mota, Lara Jansiski Motta, Pamella de Barros Motta, Raquel Agnelli MesquitaFerrari, Kristianne Porta Santos Fernandes and Sandra Kalil Bussadori

    BMC Complementary and Alternative Medicine 2017 17:391

    Published on: 8 August 2017

  3. Study protocol

    Study protocol on comparative effectiveness of mindfulness meditation and qigong on psychophysiological outcomes for patients with colorectal cancer: a randomized controlled trial

    Colorectal cancer imposes threats to patients’ well-being. Although most physical symptoms can be managed by medication, psychosocial stressors may complicate survival and hamper quality of life. Mindfulness a...

    Rainbow T. H. Ho, Adrian H. Y. Wan, Jessie S. M. Chan, S. M. Ng, K. F. Chung and Cecilia L. W. Chan

    BMC Complementary and Alternative Medicine 2017 17:390

    Published on: 8 August 2017

  4. Research article

    Effect of a herbal extract powder (YY-312) from Imperata cylindrica Beauvois, Citrus unshiu Markovich, and Evodia officinalis Dode on body fat mass in overweight adults: a 12-week, randomized, double-blind, placebo-controlled, parallel-group clinical trial

    YY-312 is a herbal extract powder from Imperata cylindrica Beauvois, Citrus unshiu Markovich, and Evodia officinalis Dode, which have health promoting effects, including body fat reduction. We aimed to evaluate t...

    Young-Gyu Cho, Ji-Hye Jung, Jae-Heon Kang, Jin Soo Kwon, Seung Pil Yu and Tae Gon Baik

    BMC Complementary and Alternative Medicine 2017 17:375

    Published on: 28 July 2017

  5. Study protocol

    Influence of the patient-practitioner interaction context on acupuncture outcomes in functional dyspepsia: study protocol for a multicenter randomized controlled trial

    In the treatment of functional dyspepsia, the placebo effect has been reported to be high, and the influence of the patient-practitioner relationship may be a major component of this effect. The specific and n...

    Seok-Jae Ko, Jae-Woo Park, Jungtae Leem, Ted J. Kaptchuk, Vitaly Napadow, Braden Kuo, Jessica Gerber, Laurie Dimisko, Inkwon Yeo, Junhee Lee and Jinsung Kim

    BMC Complementary and Alternative Medicine 2017 17:363

    Published on: 14 July 2017

  6. Research article

    Patient benefit of dog-assisted interventions in health care: a systematic review

    Dogs are the most common companion animal, and therefore not surprisingly a popular choice for animal-assisted interventions. Dog-assisted interventions are increasingly used in healthcare. The aim of the revi...

    Martina Lundqvist, Per Carlsson, Rune Sjödahl, Elvar Theodorsson and Lars-Åke Levin

    BMC Complementary and Alternative Medicine 2017 17:358

    Published on: 10 July 2017

  7. Study protocol

    Chinese acute ischemic stroke treatment outcome registry (CASTOR): protocol for a prospective registry study on patterns of real-world treatment of acute ischemic stroke in China

    Stroke presents a serious health problem in China. Despite progresses made in recent years, there is still a lack of effective treatments for acute ischemic stroke (AIS) in clinical practices.

    Weiping Sun, Qianhua Ou, Zhijun Zhang, Jiazhi Qu and Yining Huang

    BMC Complementary and Alternative Medicine 2017 17:357

    Published on: 6 July 2017

  8. Study protocol

    Moxibustion for cancer-related fatigue: study protocol for a randomized controlled trial

    Cancer-related fatigue is one of the most common symptoms experienced by cancer patients, and it diminishes their quality of life. However, there is currently no confirmed standard treatment for cancer-related...

    Mikyung Kim, Jung-Eun Kim, Hye-Yoon Lee, Ae-Ran Kim, Hyo-Ju Park, O-Jin Kwon, Eun-Jung Kim, Yeon-Cheol Park, Byung-Kwan Seo, Jung Hyo Cho and Joo-Hee Kim

    BMC Complementary and Alternative Medicine 2017 17:353

    Published on: 5 July 2017

  9. Research article

    Psychophysical responses in patients receiving a mock laser within context of an acupuncture clinical trial: an interoceptive perspective

    The psychophysical responses induced by verum acupuncture are characterized by a constellation of unique subjective sensory responses commonly termed De Qi. Furthermore, a variety of sham interventions have be...

    Shohreh Razavy, Marcus Gadau, Shi Ping Zhang, Fu Chun Wang, Sergio Bangrazi, Christine Berle, Mahrita Harahap, Tie Li, Wei Hong Li and Christopher Zaslawski

    BMC Complementary and Alternative Medicine 2017 17:348

    Published on: 3 July 2017

  10. Research article

    Rhythm-centred music making in community living elderly: a randomized pilot study

    Quality of life has become an important aspect in the measurement of the health of an individual as the population ages. Rhythm-centred music making (RMM) has been shown to improve physical, psychological and ...

    Angela Frances Yap, Yu Heng Kwan, Chuen Seng Tan, Syed Ibrahim and Seng Bin Ang

    BMC Complementary and Alternative Medicine 2017 17:311

    Published on: 14 June 2017

  11. Research article

    Chinese herbal Pulian ointment in treating psoriasis vulgaris of blood-heat syndrome: a multi-center, double-blind, randomized, placebo-controlled trial

    Traditional Chinese medicine (TCM) has a long history in the treatment of psoriasis vulgaris. We aimed to evaluate the clinical efficacy and safety of Chinese herbal Pulian ointment in treating psoriasis vulga...

    Nuo Li, Wenbin Zhao, Jianmin Xing, Jianping Liu, Guangzhong Zhang, Yunbi Zhang, Yuanwen Li, Wali Liu, Fei Shi and Yanping Bai

    BMC Complementary and Alternative Medicine 2017 17:264

    Published on: 15 May 2017

  12. Research article

    Effects of hyperthermic baths on depression, sleep and heart rate variability in patients with depressive disorder: a randomized clinical pilot trial

    Despite advances in the treatment of depression, one-third of depressed patients fail to respond to conventional antidepressant medication. There is a need for more effective treatments with fewer side effects. T...

    Johannes Naumann, Julian Grebe, Sonja Kaifel, Tomas Weinert, Catharina Sadaghiani and Roman Huber

    BMC Complementary and Alternative Medicine 2017 17:172

    Published on: 28 March 2017

  13. Research article

    Effects of mindfulness-based interventions on biomarkers in healthy and cancer populations: a systematic review

    Only a small number of articles have investigated the relationship between mindfulness-based interventions (MBIs) and biomarkers. The aim of this systematic review was to study the effect of MBIs on specific b...

    Kenji Sanada, Marta Alda Díez, Montserrat Salas Valero, María C. Pérez-Yus, Marcelo M. P. Demarzo, Jesús Montero-Marín, Mauro García-Toro and Javier García-Campayo

    BMC Complementary and Alternative Medicine 2017 17:125

    Published on: 23 February 2017

  14. Research article

    Feasibility study of transfer function model on electrocardiogram change caused by acupuncture

    Acupuncture treatments that regulate the heart are used to treat various clinical disorders and conditions. Although many studies have been conducted to measure quantitatively the effects of acupuncture, thus ...

    Haebeom Lee, Hyunho Kim, Jungkuk Kim, Hwan-Sup Oh, Young-Jae Park and Young-Bae Park

    BMC Complementary and Alternative Medicine 2017 17:101

    Published on: 8 February 2017

  15. Research article

    A Randomized controlled trial of the effect of yoga and peer support on glycaemic outcomes in women with type 2 diabetes mellitus: a feasibility study

    Type two diabetes is a complex and demanding chronic disease and its impact in a state (Kerala) which leads India in terms of the number of people with Diabetes is profound. Though the male to female ratio amo...

    Aswathy Sreedevi, Unnikrishnan Ambika Gopalakrishnan, Sundaram Karimassery Ramaiyer and Leelamoni Kamalamma

    BMC Complementary and Alternative Medicine 2017 17:100

    Published on: 7 February 2017

  16. Research article

    Effects of an L-arginine-based multi ingredient product on endothelial function in subjects with mild to moderate hypertension and hyperhomocysteinemia - a randomized, double-blind, placebo-controlled, cross-over trial

    Nutrition plays an important role in prevention and management of cardiovascular diseases (CVD) in early stages. Recent research demonstrated beneficial effects of various nutritional ingredients on vascular h...

    Claudia A. Reule, Birgit Goyvaerts and Christiane Schoen

    BMC Complementary and Alternative Medicine 2017 17:92

    Published on: 2 February 2017

  17. Research article

    A comparative study on the effects of systemic manual acupuncture, periauricular electroacupuncture, and digital electroacupuncture to treat tinnitus: A randomized, paralleled, open-labeled exploratory trial

    Many previous studies of electroacupuncture used combined therapy of electroacupuncture and systemic manual acupuncture, so it was uncertain which treatment was effective. This study evaluated and compared the...

    Bong Hyun Kim, Kyuseok Kim and Hae Jeong Nam

    BMC Complementary and Alternative Medicine 2017 17:85

    Published on: 31 January 2017

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