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Fig. 3 | BMC Complementary and Alternative Medicine

Fig. 3

From: Inhibition of airway remodeling and inflammatory response by Icariin in asthma

Fig. 3

Influence of ICA on expression of remodeling markers. Wild-type BALB/c female mice received vehicle or 0.2 ml sensitizing mixture (100 μg OVA and 1 mg aluminum hydroxide gel in sterile saline solution) on days 1 and 8. Then, mice were inhaled 1% OVA once a day for 0.5 h on days 16–43, and mice received vehicle or ICA (25, 50, or 100 mg/kg) or 1 mg/kg DXM 1 h before OVA inhalation. a TGF-β1 IHC in lung sections. b The percentage of TGF-β1 positive area . c The OD of TGF-β1 positive cells. d VEGF IHC in lung sections. e The percentage of VEGF positive area . f The OD of VEGF positive cells. g Western blot analysis of TGF-β1 and VEGF expression in mice lungs tissues. Results are shown as mean ± SEM (n = 10) . *P < 0.05 versus control group and #P < 0.05 versus OVA group

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