Fig. 2
From: Inhibition of airway remodeling and inflammatory response by Icariin in asthma
Changes in pulmonary function, pulmonary inflammation and airway remodeling following OVA exposure in mice treated with ICA. Wild-type BALB/c female mice were received vehicle or 0.2 ml sensitizing mixture (100 μg OVA and 1 mg aluminum hydroxide gel in sterile saline solution) on days 1 and 8. Then, mice were inhaled 1% OVA once a day for 0.5 h on days 16–43, and mice received vehicle or ICA (25, 50, or 100 mg/kg) or 1 mg/kg DXM 1 h before OVA inhalation. a Responsiveness to inhaled methacholine was measured using whole-body barometric plethysmography in awake, unrestrained mice. b H&E staining was performed in mice lungs sections to observe the inflammation degree and measure the remodeling related indicators: Wam/ Pbm (c)、Wai/ Pbm (d)、N (e). Data are shown as mean ± SEM (n = 10). *P < 0.05 versus control group and #P < 0.05 versus OVA group