Table 1 GRADE Assessment

Primary outcome

High Certainty

(High to Moderate quality evidence)

–

None

–

–

Moderate Certainty

(High to Low or Moderate to Low quality evidence)

Group 1

Amongst the best interventions

None

–

–

Group 2

Inferior to the best interventions

PB + MP

79%

Moderate to Low

PP

70%

High to Low

EA

68%

High to Low

Low Certainty

(High to Very low or Moderate to Very low or Low to Very low quality evidence)

Group 1

Amongst the best interventions

None

–

–

Group 2

Inferior to the best interventions

IF+PP

72%

Moderate to Very low

CHD

70%

Low to Very low

MP + CHD

68%

Low to Very low

Spontaneous bowel movements count

High Certainty

(High to Moderate quality evidence)

–

None

–

–

Moderate Certainty

(High to Low or Moderate to Low quality evidence)

Group 1

Amongst the best interventions

CSBS

90%

High to Low

RT

81%

High to Low

Group 2

Inferior to the best interventions

None

–

–

Low Certainty

(High to Very low or Moderate to Very low or Low to Very low quality evidence)

Group 1

Amongst the best interventions

CHD

80%

Moderate to Very low

Group 2

Inferior to the best interventions

SL

69%

High to Very low

LT + PB

69%

Low to Very low

Bristol score

High Certainty

(High to Moderate quality evidence)

Group 1

Amongst the best interventions

None

–

–

Group 2

Inferior to the best interventions

PEG

78%

High to Moderate

Moderate Certainty

(High to Low or Moderate to Low quality evidence)

Group 1

Amongst the best interventions

LT + PB

80%

Moderate to Low

Group 2

Inferior to the best interventions

None

–

–

Low Certainty

(High to Very low or Moderate to Very low or Low to Very low quality evidence)

Group 1

Amongst the best interventions

None

–

–

Group 2

Inferior to the best interventions

ACE

77%

High to Very low

CHD

70%

High to Very low