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Table 1 IC50 values of Carpinus tschonoskii leaf (CTL) extract and tellimagrandin I (TI) on each bioactivity, including free radical scavenging activity, inhibitory activity of NO production, IL-6, IL-8 and 5α-reductase

From: Anti-acne vulgaris effect including skin barrier improvement and 5α-reductase inhibition by tellimagrandin I from Carpinus tschonoskii

Samples

IC50

radical scavenging activity

inhibitory activity of NO

inhibitory activity of IL-6

inhibitory activity of IL-8

inhibitory activity on 5α-reductase

(μg mL−1)

CTL

31.42 ± 0.73a

5.98 ± 0.33a

14.20 ± 7.07a

7.46 ± 2.60a

197.81 ± 1.92a

Positive Control

14.67 ± 2.90b

1.48 ± 0.98b

2.98 ± 1.47b

0.74 ± 0.09b

40.65 ± 9.56b

Compound (μM)

TI

12.88 ± 0.30a

5.44 ± 1.84a, b

6.82 ± 2.37a

0.56 ± 0.56a

331.75 ± 14.62a

Positive Control

9.13 ± 0.49b

2.35 ± 1.14b

6.68 ± 1.86a

0.56 ± 0.52a

45.98 ± 15.40b

  1. The results were expressed as mean ± standard deviation (SD) of triplicate experiments. (n = 3) a-bin the same column are significantly different, p < 0.05. Positive control of free radical scavenging experiment is ascorbic acid, positive control of inhibitor activity of NO production is L-NMMA, positive control of inhibitory activity of IL-6 and IL-8 is EGCG, positive control of inhibitory activity of 5α-reductase is Finasteride