Anti-inflammatory and cytotoxic activities of the extracts, fractions, and chemical constituents isolated from Luehea ochrophylla Mart

Table 4 In vitro effect of lupeol and β-sitosterol-3-O-β-D-glucopyranoside on the proliferation of human cancer cell lines and non-tumorigenic cell line (Vero cells)

Compounds	MDA-MB-231		MCF-7		HCT-116		Vero
Compounds	IC₅₀ ± SD	SI	IC₅₀ ± SD	SI	IC₅₀ ± SD	SI	IC₅₀ ± SD
Lupeol	60 ± 17.2	0.8	67 ± 22.4	0.8	35.2 ± 13.2	1.5	51 ± 18.2
β-Sitosterol-3-O-β-D-glucopyranoside	33 ± 10.1	0.6	11 ± 5.2	1.9	1.279 ± 0.7	16.4	21 ± 9.9
Cisplatin	> 100		> 100		> 100		13.05 ± 0.6

Data are presented as mean ± SD. IC50 50% inhibition of cell growth. SI Selectivity index calculated as follows IC50 (μg/mL) for Vero / IC50 (μg/mL) for tumor cells

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