The fallacy of enzymatic hydrolysis for the determination of bioactive curcumin in plasma samples as an indication of bioavailability: a comparative study

Table 2 C_max ± SEM (ng/mL) for human plasma samples from 8 subjects that were assayed with and without enzymatic hydrolysis

NON-HYDROLYZED			HYDROLYZED
Curcumin	Curcumin Glucuronide	Total Curcumin^a	Curcumin	Tetrahydrocurcumin	Total Curcumin^a
0.71 ± 0.71	28.8 ± 13.4	19.5 ± 9.0	129.4 ± 44.7	313.5 ± 45.0	369.1 ± 39.1

^aCorrected—curcumin quantity from each form adjusted by molecular weights for each analyte

ISSN: 2662-7671