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Table 1 Effect of SMI and / or DOX treatment on animal characteristics

From: Protective effect of Shenmai injection on doxorubicin-induced cardiotoxicity via regulation of inflammatory mediators

Group

Ascites (mL)

First Body Weight (g)

Final Body Weight (g)

Heart Weight (g)

HW/BW (mg/g)

Control

0.00 ± 0.00#

23.24 ± 1.92

31.38 ± 1.57#

0.14 ± 0.02#

4.31 ± 0.49

DOX

1.43 ± 0.32*

23.15 ± 2.08

26.17 ± 9.08*

0.11 ± 0.03*

4.06 ± 0.87

SM

0.00 ± 0.00#

23.02 ± 2.36

31.12 ± 1.46#

0.13 ± 0.01#

4.28 ± 0.34

DOX + SMI(L)

1.35 ± 0.30*

23.09 ± 2.16

26.47 ± 1.38*

0.10 ± 0.01*

3.61 ± 0.19*

DOX + SMI(M)

0.89 ± 0.16*#

23.49 ± 1.88

25.80 ± 1.69*

0.09 ± 0.01*

3.65 ± 0.28*

DOX + SMI(H)

0.00 ± 0.00#

23.07 ± 2.32

27.69 ± 1.78*#

0.12 ± 0.02*

4.22 ± 0.29

DOX + Aft-SMI(H)

0.74 ± 0.62*#

23.79 ± 2.26

26.98 ± 2.67*

0.10 ± 0.02*

3.55 ± 0.41*#

  1. All values are mean ± S.D. (n = 10). *, significantly different (P < 0.05) from respective values in the control group. #, significantly different (P < 0.05) from respective values in the DOX group