Fig. 1

Histopathological observation of liver samples. a N-C group showed normal arrangement of hepatocytes and sinusoids (Green arrow) (H&E ×20); b N-Cd group showed infiltration of the portal tract with inflammatory cells (Red arrow), vacuolation of liver cell (Blue arrow), hydropic degeneration (Black arrow), nuclear pyknosis and karyorrhexis (Yellow arrow), and fibrosis (White arrow) (H&E ×40); c N-P group showed hepatocytes with regular and large spheroidal nucleus (Green arrow), normal sinusoids (Green arrow), mild inflammatory cells (Red arrow) and low fat deposition (White arrow) (H&E × 20); d N-PCd group showed some normal hepatocytes with central vein (Green arrow), less inflammation (Red arrow), fatty changes and fibrosis (White arrow), karyorrhexis and karyolysis (Yellow arrow) (H&E × 40); e DM-P group showed normal appearance of hepatocytes (Green arrow), mild inflammation (Red arrow), fibrosis (White arrow) and nuclear pyknosis (Yellow arrow) (H&E x 40); f DM-PCd group showed restoration of hepatocytes (Green arrow), karyorrhexis and karyolysis (Yellow arrow), reduced both inflammation (Red arrow) and fatty changes (White arrow) (H&E × 40)