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Table 2 Pharmacokinetic parameters of oxyresveratrol alone and in combination with piperine

From: Comparative pharmacokinetics of oxyresveratrol alone and in combination with piperine as a bioenhancer in rats

Parameters Intravenous Oral
Oxyresveratrol alone (10 mg/kg) Oxyresveratrol + piperine (10 + 1 mg/kg) Oxyresveratrol alone (100 mg/kg) Oxyresveratrol + piperine (100 + 10 mg/kg)
Oxyresveratrol
 Cmax (μg/L) N/A N/A 977.99 ± 649.59 1580.99 ± 674.31*
 Tmax (h) N/A N/A 2.08 ± 1.11 1.30 ± 0.67
 AUC0-t (μg.h/L) 825.60 ± 545.26 1455.90 ± 1953.48 5133.32 ± 1227.78 7837.18 ± 2603.81*
 AUC0-inf (μg.h/L) 825.80 ± 545.18 1471.00 ± 1945.62 5431.21 ± 1022.82 9375.27 ± 1974.32*
 MRT (h) 1.40 ± 0.29 1.60 ± 0.42 7.25 ± 4.07 11.66 ± 8.11
 Vd (L/kg) 47.30 ± 42.97 68.60 ± 60.02 105.10 ± 73.82 138.10 ± 112.83
 CL (L/h/kg) 16.90 ± 9.30 14.60 ± 8.57 19.05 ± 4.06 11.09 ± 2.52
 T1/2 (h) 1.70 ± 0.77 2.80 ± 1.60 3.72 ± 1.95 8.67 ± 6.55
 Relative bioavailability (%) 100 178 100 173
Oxyresveratrol glucuronide
 AUC0-t (μg.h/L) 20,875.50 ± 19,742.93 1190.60 ± 231.25 10,518.33 ± 6239.13 6977.34 ± 811.94
 AUC0-inf (μg.h/L) 20,875.80 ± 19,742.99 1640.00 ± 743.29 10,993.61 ± 6140.74 7491.24 ± 522.99
 Ratio of AUCoxyresveratrol glucuronide/AUCoxyresveratrol 25.28 1.11 2.02 0.80*
  1. Data are presented as mean ± S.D. (n = 6), *p < 0.05 for Oxyresveratrol alone vs Oxyresveratrol + piperine