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Table 2 Pharmacokinetic parameters of oxyresveratrol alone and in combination with piperine

From: Comparative pharmacokinetics of oxyresveratrol alone and in combination with piperine as a bioenhancer in rats

Parameters

Intravenous

Oral

Oxyresveratrol alone (10 mg/kg)

Oxyresveratrol + piperine (10 + 1 mg/kg)

Oxyresveratrol alone (100 mg/kg)

Oxyresveratrol + piperine (100 + 10 mg/kg)

Oxyresveratrol

 Cmax (μg/L)

N/A

N/A

977.99 ± 649.59

1580.99 ± 674.31*

 Tmax (h)

N/A

N/A

2.08 ± 1.11

1.30 ± 0.67

 AUC0-t (μg.h/L)

825.60 ± 545.26

1455.90 ± 1953.48

5133.32 ± 1227.78

7837.18 ± 2603.81*

 AUC0-inf (μg.h/L)

825.80 ± 545.18

1471.00 ± 1945.62

5431.21 ± 1022.82

9375.27 ± 1974.32*

 MRT (h)

1.40 ± 0.29

1.60 ± 0.42

7.25 ± 4.07

11.66 ± 8.11

 Vd (L/kg)

47.30 ± 42.97

68.60 ± 60.02

105.10 ± 73.82

138.10 ± 112.83

 CL (L/h/kg)

16.90 ± 9.30

14.60 ± 8.57

19.05 ± 4.06

11.09 ± 2.52

 T1/2 (h)

1.70 ± 0.77

2.80 ± 1.60

3.72 ± 1.95

8.67 ± 6.55

 Relative bioavailability (%)

100

178

100

173

Oxyresveratrol glucuronide

 AUC0-t (μg.h/L)

20,875.50 ± 19,742.93

1190.60 ± 231.25

10,518.33 ± 6239.13

6977.34 ± 811.94

 AUC0-inf (μg.h/L)

20,875.80 ± 19,742.99

1640.00 ± 743.29

10,993.61 ± 6140.74

7491.24 ± 522.99

 Ratio of AUCoxyresveratrol glucuronide/AUCoxyresveratrol

25.28

1.11

2.02

0.80*

  1. Data are presented as mean ± S.D. (n = 6), *p < 0.05 for Oxyresveratrol alone vs Oxyresveratrol + piperine