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Table 1 Tolerability of oxyresveratrol alone and in combination with piperine

From: Comparative pharmacokinetics of oxyresveratrol alone and in combination with piperine as a bioenhancer in rats

Parameters

Intravenous

Oral

Oxyresveratrol (10 mg/kg)

Oxyresveratrol + piperine (10 + 1 mg/kg)

Oxyresveratrol (100 mg/kg)

Oxyresveratrol + piperine (100 + 10 mg/kg)

Predose (0 h)

Postdose (24 h)

Predose (0 h)

Postdose (24 h)

Predose (0 h)

Postdose (24 h)

Predose (0 h)

Postdose (24 h)

AST (U/L)

42.00 ± 7.15

45.40 ± 3.78

34.60 ± 17.03

46.75 ± 5.57

32.40 ± 16.47

40.83 ± 22.39

17.66 ± 13.50

23.66 ± 17.32

ALT (U/L)

5.00 ± 0.00

5.80 ± 1.09

9.40 ± 1.67

7.50 ± 2.88

9.40 ± 9.28

6.83 ± 3.25

7.00 ± 2.28

11.40 ± 11.63

Creatinine (mg/dL)

0.25 ± 0.15

0.32 ± 0.08

0.22 ± 0.03

0.24 ± 0.08

0.17 ± 0.01

0.17 ± 0.01

0.22 ± 0.03

0.20 ± 0.01

  1. Data are presented as mean ± S.D. (n = 6)