Parameters | Intravenous | Oral | ||||||
---|---|---|---|---|---|---|---|---|
Oxyresveratrol (10 mg/kg) | Oxyresveratrol + piperine (10 + 1 mg/kg) | Oxyresveratrol (100 mg/kg) | Oxyresveratrol + piperine (100 + 10 mg/kg) | |||||
Predose (0 h) | Postdose (24 h) | Predose (0 h) | Postdose (24 h) | Predose (0 h) | Postdose (24 h) | Predose (0 h) | Postdose (24 h) | |
AST (U/L) | 42.00 ± 7.15 | 45.40 ± 3.78 | 34.60 ± 17.03 | 46.75 ± 5.57 | 32.40 ± 16.47 | 40.83 ± 22.39 | 17.66 ± 13.50 | 23.66 ± 17.32 |
ALT (U/L) | 5.00 ± 0.00 | 5.80 ± 1.09 | 9.40 ± 1.67 | 7.50 ± 2.88 | 9.40 ± 9.28 | 6.83 ± 3.25 | 7.00 ± 2.28 | 11.40 ± 11.63 |
Creatinine (mg/dL) | 0.25 ± 0.15 | 0.32 ± 0.08 | 0.22 ± 0.03 | 0.24 ± 0.08 | 0.17 ± 0.01 | 0.17 ± 0.01 | 0.22 ± 0.03 | 0.20 ± 0.01 |