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Table 1 Tolerability of oxyresveratrol alone and in combination with piperine

From: Comparative pharmacokinetics of oxyresveratrol alone and in combination with piperine as a bioenhancer in rats

Parameters Intravenous Oral
Oxyresveratrol (10 mg/kg) Oxyresveratrol + piperine (10 + 1 mg/kg) Oxyresveratrol (100 mg/kg) Oxyresveratrol + piperine (100 + 10 mg/kg)
Predose (0 h) Postdose (24 h) Predose (0 h) Postdose (24 h) Predose (0 h) Postdose (24 h) Predose (0 h) Postdose (24 h)
AST (U/L) 42.00 ± 7.15 45.40 ± 3.78 34.60 ± 17.03 46.75 ± 5.57 32.40 ± 16.47 40.83 ± 22.39 17.66 ± 13.50 23.66 ± 17.32
ALT (U/L) 5.00 ± 0.00 5.80 ± 1.09 9.40 ± 1.67 7.50 ± 2.88 9.40 ± 9.28 6.83 ± 3.25 7.00 ± 2.28 11.40 ± 11.63
Creatinine (mg/dL) 0.25 ± 0.15 0.32 ± 0.08 0.22 ± 0.03 0.24 ± 0.08 0.17 ± 0.01 0.17 ± 0.01 0.22 ± 0.03 0.20 ± 0.01
  1. Data are presented as mean ± S.D. (n = 6)