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Table 5 Effects of BZ formula and its main components timosaponin BII and mangiferin on P450 activity in rat liver microsomes

From: Baihe Zhimu formula attenuates the efficacy of tamoxifen against breast cancer in mice through modulation of CYP450 enzymes

Names

CYP450s

IC50 (μg/mL)

ZB formula

1A2

93.2 ± 2.1

2D6

45.6 ± 2.6

3A4

74.4 ± 6.2

Timosaponin B II

1A2

>  100

2D6

>  100

3A4

>  100

Mangiferin

1A2

90.6 ± 5.1

2D6

41.3 ± 4.3

3A4

93.8 ± 2.2