From: Modulation of cancer signalling pathway(s) in two -stage mouse skin tumorigenesis by annonacin
Features/ Groups | Inflammation | Degeneration | Necrosis | Sinusoidal dilatation | Microvesicular steatosis | |||||
---|---|---|---|---|---|---|---|---|---|---|
Distribution (n = 10) | Mean score ± S.E.M | Distribution (n = 10) | Mean score ± S.E.M | Distribution (n = 10) | Mean score ± S.E.M | Distribution (n = 10) | Mean score ± S.E.M | Distribution (n = 10) | Mean score ± S.E.M | |
I (vehicle control) | 10 | 1.0 ± 0.0 | 0 | 0.0 ± 0.0 | 0 | 0.0 ± 0.0a | 0 | 0.0 ± 0.0 | 0 | 0.0 ± 0.0b |
II (carcinogen control) | 10 | 1.8 ± 0.1a | 2 | 0.3 ± 0.2a | 0 | 0.0 ± 0.0a | 8 | 1.2 ± 0.8a | 10 | 1.7 ± 0.2a |
III (treatment, annonacin) | 10 | 1.0 ± 0.0 | 0 | 0.0 ± 0.0 | 0 | 0.0 ± 0.0a | 0 | 0.0 ± 0.0 | 4 | 0.4 ± 0.2bc |
IV (treatment control) | 10 | 1.0 ± 0.0 | 0 | 0.0 ± 0.0 | 0 | 0.0 ± 0.0a | 0 | 0.0 ± 0.0 | 2 | 0.2 ± 0.1b |
V (reference, curcumin) | 10 | 1.2 ± 0.5 | 0 | 0.0 ± 0.0 | 0 | 0.0 ± 0.0a | 0 | 0.0 ± 0.0 | 4 | 0.4 ± 0.2bc |