Fig. 1

ASH-WEX improves the locomotor coordination impaired due to LPS-induced sickness behavior During rotarod test (n = 8/group), ASH-WEX supplemented LPS (LPS + ASH-WEX)-treated rats exhibited better performance than LPS-treated animals as evaluated by their (a) latency to fall and (b) time spent on rotating rod. ASH-WEX administration also improved the performance of LPS + ASH-WEX rats in narrow beam walking test which was adversely affected by LPS as assessed by (c) time taken and (d) paw slippage to cross the beam thus implying their intact motor functions. Values are expressed as mean ± SEM. *p ≤ 0.05 control versus ASH-WEX alone and LPS + ASH-WEX groups. ⁺p ≤ 0.05 control versus LPS alone group. ^#p ≤ 0.05 LPS alone versus LPS + ASH-WEX group (one-way ANOVA with Holm-Sidak post hoc test)