| Screening | Attachment | Penetration | |||
---|---|---|---|---|---|---|
IC50 (μg/ml) | SI | IC50 (μg/ml) | SI | IC50 (μg/ml) | SI | |
P. giganteus HAE | 344.8 ± 35.4** | 12.4 ± 2.2** | – | – | 1731 ± 160** | 2.5 ± 0.3** |
L. rhinocerotis HAE | 485.9 ± 69.5** | 7.4 ± 0.4** | – | – | – | – |
S. commune HAE | 312.9 ± 14.1** | 13.7 ± 4.8* | – | – | 943.1 ± 70.4** | 4.5 ± 0.4** |
H. erinaceus HAE | 680.6 ± 79.3** | 7.8 ± 2.6* | – | – | 2080.2 ± 252.7** | 2.5 ± 0.3** |
P. giganteus ASE | 637.9 ± 40.3** | 15.7 ± 1** | 872 ± 63.2** | 11.5 ± 0.9** | 315.4 ± 52.4** | 32.3 ± 5.7** |
L. rhinocerotis ASE | 399.2 ± 18.9** | 7.6 ± 0.6** | 261.2 ± 38.3** | 11.9 ± 1.7** | 226.3 ± 157.1 | 17.5 ± 8.7 |
S. commune ASE | 424.9 ± 76.6** | 24.1 ± 4.4** | 1245.8 ± 73.7** | 8.1 ± 0.5** | 279.3 ± 27.3** | 36 ± 3.7** |
H. erinaceus ASE | 574.4 ± 83.4** | 17.7 ± 2.7** | 327.6 ± 29.2** | 30.7 ± 2.9** | 278.7 ± 87* | 38.2 ± 11.4* |
Ribavirin | 80.7 ± 1.8** | 10.9 ± 2.8** | – | – | 205 ± 15.2** | 4.3 ± 0.5** |