Skip to main content

Advertisement

Table 1 The fraction affected level (Fa) of Huaier and 5-FU in individual or in combination, and the combination index (CI) values of combination after 24 h

From: The synergistic antitumor effect of Huaier combined with 5-Florouracil in human cholangiocarcinoma cells

Huaier (mg/ml) 5-FU (μg/ml) Concentration ratio (Hauier: 5-FU) Fa of Huaier Fa of 5-FU Fa of combination CI
1.5 7.5   3.30% 17.10% 18.10% 1.09
3 15   9.10% 21.20% 25.20% 1.16
6 30 1:05 25.20% 27.40% 50.90% 0.59
12 60   43.40% 37.90% 67.40% 0.63
24 120   69.80% 45.40% 81.20% 0.71
  1. CI was used for a quantitative measure of the extent of the interaction between two drugs. The CI > 1 indicates antagonism; CI < 1 means synergy; CI = 1 indicates additive effects. The CI values< 1 indicates that the combination (24 h) of Huaier (1.5–24 mg/ml) and 5-FU (7.5–120 μg/ml) was synergistic on Huh28 cells