Table 1 The MIC (μg/ml) of CG sub-fractions, synthetic and commercially sourced gallate derivatives against a panel of six bacteria
From: Discovery, synthesis and antibacterial evaluation of phenolic compounds from Cylicodiscus gabunensis
Fractions/pure compound | S. aureus | S. epidermidis | E. coli | B. subtilis | B. cereus | A. faecalis |
|---|---|---|---|---|---|---|
CGEEA-F5 | 256 | 128 | 1024 | >  1024 | 1024 | 256 |
CGEEA-F5–8 | 128 | 64 | 512 | NA | NA | 128 |
3,4,5-Trihydroxybenzoic acid (gallic acid, 1) | 2000 | 500 | 1000 | 1000 | 1000 | 1000 |
3,4-Dihydroxybenzoic acid (2) | 1000 | 500 | 1000 | 1000 | 1000 | 500 |
4-Hydroxy-3-methoxybenzoic acid (3) | 1000 | 1000 | 1000 | 1000 | 1000 | 500 |
4-Hydroxy-3,5-dimethoxybenzoic acid (4) | 1000 | 1000 | 500 | 1000 | 2000 | 500 |
3,4,5- Trimethoxybenzoic acid (5) | 1000 | 1000 | 1000 | 1000 | 1000 | 500 |
Ethyl 3,4,5-trihydroxybenzoate (ethyl gallate, 6) | 1000 | 250 | 62.5 | 1000 | 1000 | 250 |
Propyl 3,4,5-trihydroxybenzoate (7) | 500 | 250 | 125 | 1000 | 1000 | 250 |
Propan-2-yl 3,4,5-trihydroxybenzoate (8) | 1000 | 250 | 62.5 | >1000 | >1000 | 250 |
2-Methylpropyl 3,4,5-trihydroxybenzoate (9) | 500 | 250 | 500 | 1000 | 1000 | 500 |
2-Methylbutyl 3,4,5-trihydroxybenzoate (10) | 250 | 250 | 250 | 250 | 500 | 250 |
3-Methylbutyl 3, 4, 5-trihydroxybenzoate (11) | 250 | 250 | 250 | 250 | 500 | 500 |
3-Methylbut-2-en-1-yl 3,4, 5-trihydroxybenzoate (12) | 250 | 250 | 500 | 500 | 1000 | 500 |
Dodecyl 3,4,5-trihydroxybenzoate (lauryl gallate, 13) | 8 | 8 | >1000 | 31.25 | 31.25 | 1000 |
Ampicillin | ≤0.5 | ≤0.5 | ≤0.5 | ≤0.5 | >64 | 16 |