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Table 8 Packed cell volume, rectal temperature and body weight of infected mice treated with solvent fractions of the leaves of Olea europaea in the 4-day suppressive test

From: Evaluation of the anti-malarial activity of crude extract and solvent fractions of the leaves of Olea europaea (Oleaceae) in mice

Groups

Packed cell volume

Rectal temperature

Body weight

D 0

D4

% change

D0

D4

% change

D0

D4

% change

2% TW80

59.51 ± 0.41

54.24 ± 0.51

−8.86

36.71 ± 0.08

34.83 ± 0.17

−5.12

28.57 ± 0.26

27.26 ± 0.22

−4.58

CQ25 mg/kg

60.32 ± 0.52

60.03 ± 0.52

−0.48a3

35.67 ± 0.28

35.68 ± 0.24

0.03a3

28.27 ± 0.21

28.61 ± 0.24

1.20a3

200 mg/kg CF

59.7 ± 0.70

56.11 ± 0.68

−5.85a3b3e1

36.50 ± 0.22

35.18 ± 0.21

−3.61a1b3

28.33 ± 0.15

27.15 ± 0.15

−4.17b3

400 mg/kg CF

60.18 ± 0.49

56.99 ± 0.44

−5.14a3b3

36.39 ± 0.17

35.53 ± 0.19

−3.46a2b3

28.16 ± 0.25

27.17 ± 0.28

−3.52a1b3

600 mg/kg CF

60.88 ± 0.34

57.99 ± 0.40

−4.75a3b3

35.92 ± 0.18

35.30 ± 0.16

−3.12a2b3

28.35 ± 0.73

27.4 ± 70

−3.35a2b3

2% TW80

59.51 ± 0.41

54.21 ± 0.51

−8.91

36.71 ± 0.08

34.78 ± 0.17

−5.26

28.59 ± 0.26

27.26 ± 0.37

−4.65

CQ25 mg/kg

60.32 ± 0.52

60.03 ± 0.51

−0.48a3

35.68 ± 0.29

35.68 ± 0.24

0.00a3

28.29 ± 0.22

28.61 ± 0.24

1.13a3

200 mg/kg BF

59.63 ± 0.70

56.47 ± 0.75

−5.30a3b3d1e2

36.55 ± 0.22

35.25 ± 0.20

−3.52 a1b3e2

28.20 ± 0.2

27.04 ± 0.18

−4.11b3

400 mg/kg BF

60.23 ± 0.49

57.73 ± 0.44

−4.15a3b3

36.44 ± 0.17

35.62 ± 0.20

−2.25a3b3

28.16 ± 0.32

27.21 ± 0.35

−3.37a1b3

600 mg/kg BF

60.93 ± 0.34

58.69 ± 0.40

−3.68a3b3

35.97 ± 0.18

35.5 ± 0.16

−1.31a3

27.85 ± 0.73

26.99 ± 0.71

−3.09a2b3

2% TW80

59.44 ± 0.41

54.22 ± 0.51

−8.78

36.69 ± 0.10

34.78 ± 0.14

−5.21

28.59 ± 0.26

27.26 ± 0.22

−4.65

CQ25 mg/kg

60.30 ± 0.51

60.03 ± 0.51

-.45a3

35.68 ± 0.28

35.67 ± 0.24

−0.03a3

28.29 ± 0.22

28.61 ± 0.24

1.13a3

200 mg/kg AF

59.75 ± 0.70

55.18 ± 0.68

−5.98a3b3

36.57 ± 0.22

35.14 ± 0.20

−3.90a1b3

28.36 ± 0.15

27.16 ± 0.16

−4.33b3

400 mg/kg AF

60.22 ± 0.49

55.87 ± 0.43

−5.57a3b3

36.43 ± 0.17

35.23 ± 0.19

−3.61a2b3

28.2 ± 0.25

27.01 ± 0.28

−4.22 b3

600 mg/kg AF

60.86 ± 0.35

56.69 ± 0.40

−5.22a3b3

36.02 ± 0.18

35.10 ± 0.16

−3.43a2b3

28.42 ± 0.73

27.31 ± 0.69

−3.91 b3

  1. Data are expressed as mean ± SEM; n = 6; CF, chloroform fraction; BF, butanol fraction; AF, aqueous fraction; a, compared to negative control; b, to CQ25mg/kg; c, to 200 mg/kg; d, to 400 mg/kg; e, to 600 mg/kg; 1, p < 0.05; 2, p < 0.01; 3, p < 0.001; 2% TW80, 2% Tween80; CQ chloroquine, D0 pre -treatment value on day 0, D4 post- treatment value on day 4