Evaluation of the anti-malarial activity of crude extract and solvent fractions of the leaves of Olea europaea (Oleaceae) in mice

Table 7 Parasitemia and survival time of infected mice treated with solvent fractions of the leaves of Olea europaea in the 4-day suppressive test

Groups	% Parasitemia	% Suppression	Survival time (days)
2% TW80	37.84 ± 0.51	–	7.33 ± 0.21
CQ25 mg/kg	0.00 ± 0.00	100.00^a3	28.00 ± 0.00^a3
200 mg/kg CF	25.92 ± 0.25	31.52^a3b3d2e3	10.17 ± 0.31^a3b3e1
400 mg/kg CF	24.17 ± 0.24	36.12^a3b3	10.83 ± 0.33^a3b3
600 mg/kg CF	23.45 ± 0.13	38.03^a3b3	11.17 ± 0.17^a3b3
2% TW80	38.01 ± 0.61	–	7.17 ± .017
CQ25 mg/kg	0.00 ± 0.00	100.00^a3	28.00 ± 0.00^a3
200 mg/kg BF	22.55 ± 0.28	40.68^a3b3d2e3	11.33 ± 0.33^a3b3d1e3
400 mg/kg BF	20.44 ± 0.45	46.23^a3b3e1	12.67 ± 0.33^a3b3e1
600 mg/kg BF	18.77 ± 0.22	50.63^a3b3	13.83 ± 0.31^a3b3
2% TW80	37.86 ± 0.51	–	7.17 ± 0.17
CQ25 mg/kg	0.00 ± 0.00	100.00^a3	28.00 ± 0.00^a3
200 mg/kg AF	31.25 ± 0.78	17.46^a3b3e1	8.83 ± 0.17^a3b3e1
400 mg/kg AF	30.34 ± 0.26	19.86^a3b3	9.50 ± 0.22^a3b3
600 mg/kg AF	30.03 ± 0.27	20.67^a3b3	9.83 ± 0.17^a3b3

Data are expressed as mean ± SEM; n = 6; CF, chloroform fraction; BF, butanol fraction; AF, aqueous fraction; a, compared to negative control; b, to CQ25 mg/kg; c, to 200 mg/kg; d, to 400 mg/kg; e, to 600 mg/kg; 1, p < 0.05; 2, p < 0.01; 3, p < 0.001; 2% TW80, 2% Tween80; CQ chloroquine

ISSN: 2662-7671