Antinociceptive activities of Artocarpus lacucha Buch-ham (Moraceae) and its isolated phenolic compound, catechin, in mice

Table 2 Effect of catechin and morphine in formalin-induced nociception test

Treatment	Dose (mg/Kg)	Nociceptive response (s)				Edema thickness (mm)	% inhibition
Treatment	Dose (mg/Kg)	Early Phase (0–10 min)	% inhibition	Late Phase (11–45 min)	% inhibition	Edema thickness (mm)	% inhibition
Vehicle	–	118.18 ± 2.80	–	487.37 ± 17.41	–	1.37 ± 0.03	–
Morphine	5	21.45 ± 2.29^*	81.35	22.65 ± 1.37*	95.35	0.72 ± 0.04^*	47.67
(+)-Catechin	50	114.05 ± 2.62	3.49	404.17 ± 13.08	17.07	1.34 ± 0.01	2.62
(+)-Catechin	100	112.43 ± 2.28	4.86	377.18 ± 7.11*	22.61	1.11 ± 0.02^*	19.24
(+)-Catechin	200	110.56 ± 2.38	6.45	338.19 ± 3.48*	30.61	0.92 ± 0.01^*	33.24

Data are presented as mean ± SEM (n = 5). ^* represents p < 0.001, compared to control group mice

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