Fig. 4

Effect of diclofenac, HEBA, (+)-catechin and glibenclamide treatments in the acetic acid-induced writhing test. Panel a shows the effect of HEBA and glibenclamide pre-treatment on writhing. Panel b shows the effect of (+)-catechin and glibenclamide pre-treatment on writhing. Data are presented as mean ± SEM (n = 5). ^* represents p < 0.001, compared to control group mice. a, b, and c represent p < 0.01, compared to 50, 100 and 200 mg/Kg b.w. dose treatment group respectively. HEBA = hydro-methanolic extract of the bark of A. lacucha. Gbc = glibenclamide