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Fig. 8 | BMC Complementary and Alternative Medicine

Fig. 8

From: Methanol extract of semen Ziziphi Spinosae attenuates ethanol withdrawal anxiety by improving neuropeptide signaling in the central amygdala

Fig. 8

Effects of post-MESZS infusions of CRF or UFP-101 into the CeA on anxiolytic actions of MESZS in elevated plus maze (EPM) test. At 60 min after the third treatment with 180 mg/kg/d MESZS, the rats received bilateral intra-CeA infusions of CRF or UFP-101, and then were behaviorally evaluated in the EPM. (a) The total number of entries into (open and closed) arms of EPM by rats. (b) Percentage of numbers of entries into open arms. (c) Percentage of time spent in open arms. All data are expressed as a mean ± SEM (n = 6). S: saline, DW: distilled water, EtOH: ethanol, MRS: modified Ringers’ solution, MESZS: methanol extract of Semen Ziziphi Spinosae, MESZS180: 180 mg/kg/d MESZS. ### p < 0.001 vs. S/DW/MRS group; $$ p < 0.01 and $$$ p < 0.001 vs. EtOH/DW/MRS group; @@ p < 0.01 vs. EtOH/MESZS180/MRS group (one-way ANOVA followed by Newman-Keuls post hoc test)

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