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Fig. 5 | BMC Complementary and Alternative Medicine

Fig. 5

From: Methanol extract of semen Ziziphi Spinosae attenuates ethanol withdrawal anxiety by improving neuropeptide signaling in the central amygdala

Fig. 5

Effects of MESZS on the mRNA expressions of amygdaloid (a) CRF and (b) CRFR1 during EtOHW. Immediately after the behavioral test, the mRNA levels of CRF and CRFR1 in the CeA were determined using qPCR analysis. All data are expressed as a mean ± SEM (n = 5). S: saline, DW: distilled water, EtOH: ethanol, MESZS: methanol extract of Semen Ziziphi Spinosae, MESZS180: 180 mg/kg/d MESZS. ### p < 0.001 vs. S/DW group; $$$ p < 0.001 vs. EtOH/DW group (one-way ANOVA followed by Newman-Keuls post hoc test)

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