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Table 3 Effects of AqE on aorta remodeling in L-NAME induced hypertensive mice (mean ± SD, n = 10)

From: The protective effects of polysaccharide extract from Xin-Ji-Er-Kang formula on Ang II-induced HUVECs injury, L-NAME-induced hypertension and cardiovascular remodeling in mice

Group TAA(×103μm2) LA(×103μm2) CSA(×103μm2) CSA/TAA(%) AR(μm) Lumen(μm) Media(μm) M/L(%)
Control 424.5 ± 81.2 271.7 ± 66.6 152.8 ± 17.9 36.0 ± 22.0 366.4 ± 33.8 292.5 ± 33.9 73.9 ± 4.6 25.5 ± 3.0
Model 686.8 ± 162.3** 426.4 ± 97.1** 260.3 ± 73.1** 27.9 ± 45.0 464.8 ± 56.7** 366.3 ± 44.3** 98.5 ± 17.6** 27.0 ± 3.8
L-NAME+AqE 496.6 ± 81.5# 319.0 ± 59.6# 177.6 ± 22.0# 35.8 ± 27.0 396.5 ± 33.5# 317.5 ± 30.7 78.9 ± 2.9# 25.0 ± 1.7
L-NAME+XJEK 499.9 ± 65.2# 327.1 ± 59.5 172.9 ± 22.2# 34.6 ± 34.0 398.3 ± 26.7# 321.6 ± 29.4 76.6 ± 9.6# 24.1 ± 4.2
L-NAME+Fosinopril 445.1 ± 220.2# 292.5 ± 148.9# 153.2 ± 726.7# 34.4 ± 33.0 336.3 ± 159.0# 272.1 ± 129.2# 64.7 ± 30.0# 22.1 ± 6.5
  1. TAA total aorta area, LA lumen area, CSA cross-sectional area, AR aorta radius. The vascular remodeling of the upper thoracic aorta exposed to L-NAME was observed at the end of 8th week, which could be prevented by treatment with AqE for the last 4 weeks, as well as with two positive drugs, XJEK and fosinopril. Data are expressed as mean ± SD, n = 10. **P < 0.01 vs control; #P < 0.05 vs model