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Table 4 MIC of antibiotics after the association with compound 2 + 3 at MIC/2 and MIC/4 against seven MDR bacteria strains

From: Antibacterial and antibiotic-modifying activities of fractions and compounds from Albizia adianthifolia against MDR Gram-negative enteric bacteria

Antibioticsa

Bacterial strainsb, MIC (μg/mL) of antibiotics in the absence and presence of compound 2 + 3

Compounds concentration

PA124

KP55

ATCC11296

EA27

ATCC13048

AG102

ATCC10536

PBSS (%)

CIP

0

2

0.5

0.5

0.5

4

2

0.125

 
 

CMI/2

0.5(0.25)S

0.5(1)I

0.25 (0.5)S

0.25 (0.5)S

0.125(0.031)S

0.5(0.25)S

0.125 (1)I

(5/7) 71.42%

CMI/4

0.5(0.25)S

0.5 (1)I

0.25 (0.5)S

0.5 (1)I

0.5 (0.125)S

1 (0.5)S

0.125 (1)I

(4/7) 57.14%

ERY

0

> 32

4

> 32

> 32

> 32

16

16

 
 

CMI/2

32(0.5)S

2(0.5)S

4(< 0.125)S

32 (0.5)S

32 (0.5)S

8 (0.5)S

8 (0.5)S

(7/7) 100%

CMI/4

32(0.5)S

2(0.5)S

4(< 0.125)S

32 (0.5)S

32 (0.5)S

8 (0.5)S

8 (0.5)S

(7/7) 100%

GEN

0

> 4

2

> 4

4

4

> 4

4

 
 

CMI/2

4(0.5)S

1(0.5)S

0.125(< 0.031)S

4(1)I

2(0.5)S

4 (0.5)S

2(0.5)S

(6/7) 85.71%

CMI/4

4(0.5)S

1(0.5)S

0.125(< 0.031)S

4(1)I

2(0.5)S

4 (0.5)S

2(0.5)S

(6/7) 85.71%

KAN

0

0.5

2

4

4

16

16

4

 
 

CMI/2

< 0.125(0.25)S

2(1)I

2(0.5)S

4(1)I

16(1)I

8 (0.5)S

4(1)I

(3/7) 42.85%

CMI/4

< 0.125(0.25)S

2(1)I

2(0.5)S

4(1)I

16(1)I

8 (0.5)S

4(1)I

(3/7) 42.85%

NOR

0

> 16

16

1

16

16

2

1

 
 

CMI/2

< 0.125(0.007)S

8(0.5)S

1(1)I

4(0.25)S

2(0.125)S

2 (1)I

1 (1)I

(4/7) 57.14%

CMI/4

< 0.125(0.007)S

8(0.5)S

1(1)I

4(0.25)S

4(0.25)S

2 (1)I

1 (1)I

(4/7) 57.14%

STR

0

> 32

> 32

> 32

> 32

> 32

> 32

> 32

 
 

CMI/2

32(0.5)S

16(< 0.5)S

32(0.5)S

16(< 0.5)S

32(0.5)S

16(< 0.5)S

2(< 0.062)S

(7/7) 100%

CMI/4

32(0.5)S

32(0.5)S

32(0.5)S

16(< 0.5)S

32(0.5)S

16(< 0.5)S

4(< 0.125)S

(7/7) 100%

TET

0

8

0.125

> 16

> 16

> 16

> 16

16

 
 

CMI/2

4(0.5)S

0.0625(0.5)S

8(< 0.5)S

16(0.5)S

4(< 0.25)S

1(< 0.062)S

0.125(0.007)S

(7/7) 100%

CMI/4

4(0.5)S

0.0625(0.5)S

8(< 0.5)S

16(0.5)S

4(< 0.25)S

1(< 0.062)S

0.125(0.007)S

(7/7) 100%

  1. aAntibiotics [CIP: Ciprofloxacin, ERY: Erythromycin, GEN: Gentamycin, KAN: Kanamycin, NOR: Norfloxacin, STR: Streptomycin, TET: Tetracycline]. bBacteria: Escherichia coli [ATCC10536, AG102], Pseudomonas aeruginosa [PA124], Enterobacter aerogenes [ATCC13048, EA27], Klebsiella pneumoniae [ATCC11296, KP55]. PBSS: Percentage of bacteria strain on which synergism has been observed; S: Synergy; I: Indifference; (): FIC (Fractional Inhibitory Concentration) of the antibiotics after association with compounds, 0: MIC of the antibiotic alone
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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