Fig. 4

Effect of naringin (Na) and sericin (Se) on the induction of the production of (a) TNF-α, (b) IL-12p40, (c) IL-23, and (d) IL-6. The hPBMCs from healthy subjects (untreated control) and patients with psoriasis were treated with 20 μg/mL Na, 100 μg/mL Se and Na/Se combination (20/100 μg/mL at the ratio of 1:1 (v:v). The cytokine production was measured by ELISA. Data are expressed as median (range) of 10 samples in each group (3 independent experiments, triplicate each). *P < 0.001 vs. untreated control hPBMCs from healthy subjects by Mann-Whitney U test. #P < 0.05 and ## P < 0.001 vs. untreated pPBMCs from psoriasis patients by Mann-Whitney U test. One vs. untreated pPBMCs from psoriasis patients by Mann-Whitney U test