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Table 1 IC50 values of PM produced by six strains of Lactobacillus plantarum on various cancer cells

From: Postbiotic metabolites produced by Lactobacillus plantarum strains exert selective cytotoxicity effects on cancer cells

 

IC50 value of PM produced by L. plantarum strains, % (v/v)

Cancer Cells

UL4

TL1

RS5

RG14

RG11

RI11

 MCF-7 (ATCC®HTB-22)

10

13

21

20

16

16

 HeLa (ATCC® CCL2)

20

18

24

20

N.D.

18

 Hep-G2 (ATCC®HB-8065)

22

22

27

22

N.D.

N.D.

 HT-29 (ATCC®HTB-38)

N.D.

N.D.

28

22

N.D.

N.D.

 K562 (ATCC®CCL-240)

10

5

5

5

5

5

 HL60 (ATCC®CCL-243)

5

5

9

10

1

1

  1. Notes: Human breast cancer cells MCF-7 (ATCC-HTB-22), colorectal cancer cells HT-29 (ATCC HTB-38), cervical cancer cells HeLa (ATCC CCL2) and liver cancer cells Hep-G2 (ATCC HB-8065) are anchorage-dependent cells while leukemia cells HL60 (ATCC CCL-240) and K562 (ATCC CCL-243) are suspension cells. The highest concentration of PM being tested on all cells was 30% (v/v). The IC50 values were detected after 72 h of incubation. The values reported are the means of nine replicates. N.D., no IC50 values were detected up to the concentration of 30% (v/v)