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Table 2 IC50 values and selectivity index of compounds (1 and 2), cisplatin and doxorubicin treated cancer cells

From: Cytotoxic and cell cycle arrest properties of two steroidal alkaloids isolated from Holarrhena floribunda (G. Don) T. Durand & Schinz leaves

Cell line

Drug (IC50 (μM))

Selectivity index

C1

C2

Cisplatin

Dox

C1

C2

Cisplatin

Dox

HT-29

31.06

22.36

7.07

17.38

3.31

3.82

0.87

0.27

HeLa

51.42

46.17

2.91

3.57

2.00

1.62

2.11

1.31

MCF-7

42.82

52.69

10.58

8.20

2.00

1.85

0.58

0.57

KMST-6

102.95

85.45

6.14

4.68

    
  1. C1 Compound 1, C2 Compound 2, Dox Doxorubicin. IC50 values were determined by non-linear regression of MTT assay dose-response data