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Table 2 IC50 values and selectivity index of compounds (1 and 2), cisplatin and doxorubicin treated cancer cells

From: Cytotoxic and cell cycle arrest properties of two steroidal alkaloids isolated from Holarrhena floribunda (G. Don) T. Durand & Schinz leaves

Cell line Drug (IC50 (μM)) Selectivity index
C1 C2 Cisplatin Dox C1 C2 Cisplatin Dox
HT-29 31.06 22.36 7.07 17.38 3.31 3.82 0.87 0.27
HeLa 51.42 46.17 2.91 3.57 2.00 1.62 2.11 1.31
MCF-7 42.82 52.69 10.58 8.20 2.00 1.85 0.58 0.57
KMST-6 102.95 85.45 6.14 4.68     
  1. C1 Compound 1, C2 Compound 2, Dox Doxorubicin. IC50 values were determined by non-linear regression of MTT assay dose-response data