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Table 3 LC50 (against C3A liver cells) and selectivity index (SI) values of extract, fractions and compounds of Oxyanthus speciosus

From: Fractions and isolated compounds from Oxyanthus speciosus subsp. stenocarpus (Rubiaceae) have promising antimycobacterial and intracellular activity

Samples LC50 (μg/mL) SI
Ms Ma Mt Mf
Extract 383a 1.24a 2.46a 2.25a 4.91
F1 40 0.03 0.02 0.02 0.02
F2 34 0.11 0.05 0.05 0.11
F3 60 0.38 0.19 0.19 0.19
F4 190 1.22 0.61 0.61 1.22
F5 200 1.28 0.65 0.08 0.32
F6 70 0.06 0.03 0.11 nd
F7 156 0.12 0.25 0.12 0.12
F8 510 3.27 0.82 0.20 0.41
F9 40 1.03 0.13 0.13 0.06
F10 50 1.28 0.32 0.16 0.08
F11 80 0.51 0.51 0.26 0.13
Rif > 200 nd nd nd nd
Lut > 200 > 4 > 16 > 8 > 8
RA 33 0.33 0.33 0.33 0.33
Dox 3.32 nd nd nd nd
  1. RA Rotundic acid, Rif Rifampicin, Lut Lutein, Dox Doxorubicin, Ms M. smegmatis, Ma M. aurum, Mt M. tuberculosis, Mf M. fortuitum, F1-F11 fractions, nd not determined
  2. apreviously published by Aro et al. [24]
  3. Values in bold indicates fractions with the highest selectivity indices