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Table 3 LC50 (against C3A liver cells) and selectivity index (SI) values of extract, fractions and compounds of Oxyanthus speciosus

From: Fractions and isolated compounds from Oxyanthus speciosus subsp. stenocarpus (Rubiaceae) have promising antimycobacterial and intracellular activity

Samples

LC50

(μg/mL)

SI

Ms

Ma

Mt

Mf

Extract

383a

1.24a

2.46a

2.25a

4.91

F1

40

0.03

0.02

0.02

0.02

F2

34

0.11

0.05

0.05

0.11

F3

60

0.38

0.19

0.19

0.19

F4

190

1.22

0.61

0.61

1.22

F5

200

1.28

0.65

0.08

0.32

F6

70

0.06

0.03

0.11

nd

F7

156

0.12

0.25

0.12

0.12

F8

510

3.27

0.82

0.20

0.41

F9

40

1.03

0.13

0.13

0.06

F10

50

1.28

0.32

0.16

0.08

F11

80

0.51

0.51

0.26

0.13

Rif

> 200

nd

nd

nd

nd

Lut

> 200

> 4

> 16

> 8

> 8

RA

33

0.33

0.33

0.33

0.33

Dox

3.32

nd

nd

nd

nd

  1. RA Rotundic acid, Rif Rifampicin, Lut Lutein, Dox Doxorubicin, Ms M. smegmatis, Ma M. aurum, Mt M. tuberculosis, Mf M. fortuitum, F1-F11 fractions, nd not determined
  2. apreviously published by Aro et al. [24]
  3. Values in bold indicates fractions with the highest selectivity indices
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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