Skip to main content

Advertisement

Table 2 Minimal inhibitory concentration (MIC in mg/mL) and total activity (TA) in L of extract, fractions and isolated compounds of Oxyanthus speciosus. (TA in L is calculated by dividing mass of fraction in mg (MF) by MIC in mg/mL and dividing the answer by 1000)

From: Fractions and isolated compounds from Oxyanthus speciosus subsp. stenocarpus (Rubiaceae) have promising antimycobacterial and intracellular activity

Samples Yield (%) MF (mg) Microorganisms
M. smegmatis M. aurum M. tuberculosis M. fortuitum Average MIC Average TA inL
MIC TA MIC TA MIC TA MIC TA
Extract 2.99a 26,340 0.08a 329.3 0.06a 439.0 0.17a 154.9 0.078 337.7 0.097 315.2
F1 2.02 750 1.25 0.6 2.5 0.3 2.5 0.3 2.5 0.3 2.19 0.3
F2 3.15 1160 0.31 3.7 0.625 1.8 0.625 1.9 0.31 3.7 1.02 2.8
F3 1.48 550 0.15 3.7 0.31 1.8 0.31 1.8 0.31 1.8 0.27 2.2
F4 3.08 1140 0.15 7.6 0.31 3.7 0.31 3.7 0.156 7.3 0.27 5.6
F5 1.64 610 0.15 4.1 0.31 1.9 2.5 0.2 0.625 0.9 0.78 1.8
F6 0.32 120 1.25 0.09 2.5 0.048 0.625 0.2 1.25 0.1 1.25 0.1
F7 0.43 160 1.25 0.1 0.625 0.3 1.25 0.1 1.25 0.1 1.09 0.2
F8 0.81 300 0.15 2 0.625 0.5 2.5 0.1 1.25 0.2 1.13 0.7
F9 0.08 30 0.039 0.8 0.31 0.09 0.31 0.09 0.625 0.05 0.48 0.3
F10 28.35 10,490 0.039 269 0.156 67.2 0.31 33.8 0.625 16.8 0.28 96.7
F11 29.81 11,030 0.15 73.5 0.156 71 0.31 35.6 0.625 17.6 0.31 33
Rif nd nd 12.5 nd 1.56 nd 100 nd nd nd 38.02 nd
Lut nd 6.4 0.05 na 0.013 na 0.025 na 0.025 na 0.028 na
RA nd 50 0.1 na 0.1 na 0.1 na 0.1 na 0.1 na
  1. Ms M. smegmatis, Ma M. aurum, Mt M. tuberculosis, Mf M. fortuitum, F1-F11 fractions, nd not determined, na not available, RA Rotundic acid, Rif Rifampicin, Lut Lutein
  2. aMICs previously published by Aro et al. [24]
  3. Values in bold indicates MIC and TA of fractions with good activites