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Table 3 Effect of Placebo, Phyllanthus emblica 250 mg and Phyllanthus emblica 500 mg on biomarkers

From: Evaluation of the effects of a standardized aqueous extract of Phyllanthus emblica fruits on endothelial dysfunction, oxidative stress, systemic inflammation and lipid profile in subjects with metabolic syndrome: a randomised, double blind, placebo controlled clinical study

Parameter Placebo (A) (n = 18) Phyllanthus emblica 250 mg (B) (n = 20) Phyllanthus emblica 500 mg (C) (n = 21)
Baseline 12 weeks Mean % change Baseline 12 weeks Mean % change Baseline 12 weeks Mean% change
NO (μM/L) 32.97 ± 4.02 32.58 ± 3.88 −0.94% 34.53 ± 5.81 47.88 ± 5.62 *† 41.89% 32.62 ± 3.91 48.80 ± 5.97 *† 50.70%†∞
GSH (μM/L) 421.24 ± 61.1 429.3 ± 62.4 2.15% 424.91 ± 103.16 524.05 ± 121.5 24.31% 395.07 ± 58.03 599.33 ± 62.69*† 53.22%†∞
MDA (nM/ml) 3.79 ± 0.67 3.90 ± 0.60 3.53% 3.86 ± 0.75 2.94 ± 0.57*† −21.02% 3.85 ± 0.79 2.48 ± 0.38*† −31.44% †Ns
hsCRP (mg/L) 3.61 ± 0.74 3.66 ± 0.61 2.48% 3.39 ± 0.74 2.06 ± 0.93*† −39.68% 3.51 ± 0.91 1.56 ± 0.63*† −53.77%†‡
  1. Values expressed as mean ± SD
  2. SD Standard deviation, NO Nitric oxide, GSH Glutathione, MDA Malondialdehyde, hsCRP high sensitivity C - reactive protein
  3. *p < 0.001 compared to baseline value. p < 0.001 and §p < 0.01 compared to placebo (A vs B, A vs C). p < 0.001 B vs C, p < 0.05: B vs C