Evaluation of the effects of a standardized aqueous extract of Phyllanthus emblica fruits on endothelial dysfunction, oxidative stress, systemic inflammation and lipid profile in subjects with metabolic syndrome: a randomised, double blind, placebo controlled clinical study

Table 2 Effect of Placebo, Phyllanthus emblica 250 mg and Phyllanthus emblica 500 mg on reflection index % (marker of endothelial function)

Parameter	Placebo (A) (n = 18)				Phyllanthus emblica 250 mg (B) (n = 20)				Phyllanthus emblica 500 mg (C) (n = 21)
RI (%)	Baseline	After treatment			Baseline	After treatment			Baseline	After treatment
RI (%)	Baseline	4 weeks	8 weeks	12 weeks	Baseline	4 weeks	8 weeks	12 weeks	Baseline	4 weeks	8 weeks	12 weeks
Mean ± SD	−2.27 ± 1.22	−1.88 ± 1.24	− 1.46 ± 1.61	− 0.97 ± 2.45	− 2.20 ± 0.97	− 2.39 ± 1.16	− 4.18 ± 0.87*†	−8.82 ± 1.54*†	−2.52 ± 1.13	−2.76 ± 0.99	− 4.86 ± 0.88*†‡	− 10.03 ± 1.58*†‡
p		NS	NS	NS		NS	< 0.001	< 0.001		NS	< 0.001	< 0.001

Values expressed as mean ± SD
SD standard deviation, RI Reflection index
*p < 0.001: compared to baseline value. ^†p < 0.001: compared to placebo (A vs B, A vs C), ^‡ p < 0.05: B vs C

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