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Fig. 3 | BMC Complementary and Alternative Medicine

Fig. 3

From: Leaf extracts from Dendropanax morbifera Léveille mitigate mercury-induced reduction of spatial memory, as well as cell proliferation, and neuroblast differentiation in rat dentate gyrus

Fig. 3

Immunohistochemistry for Ki67 in the dentate gyrus of the control group (a), dimethylmercury (MeHg)-treated group (b), Dendropanax morbifera leaf extract treated group with MeHg (MeHg + DML) (c), and galantamine (GAL) treated group with MeHg (MeHg + GAL) (d). In the control group, Ki67 positive nuclei (arrows) are mainly observed in the subgranular zone of the dentate gyrus. Note that few Ki67 positive nuclei are found in the MeHg-treated group, while in the MeHg + DML-treated group, Ki67 positive nuclei are relatively abundant. GCL, granule cell layer; ML, molecular layer; PoL, polymorphic layer. Scale bar = 100 μm. (e): Quantitative analysis of Ki67 positive nuclei number per section in the control, MeHg-treated, and MeHg+DML-treated rats using an image analyzer (n = 5 per group; ap <0.05, vs. control group; bp < MeHg-treated group). Values are mean ± standard error of the mean

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