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Table 2 α-glucosidase activity of methanolic extract of Cornus capitata and its fractions

From: In vitro evaluation of the α-glucosidase inhibitory potential of methanolic extracts of traditionally used antidiabetic plants

Plant extract/Fractionate

Percentage α-glucosidase inhibition

IC 50 (μg/mL)

12.5 μg/mL

25 μg/mL

50 μg/mL

100 μg/mL

200 μg/mL

400 μg/mL

 

Cornus capitata (Leaves)

63.68 ± 1.98a

97.81 ± 0.03a

98.37 ± 0.12a

97.43 ± 0.18a

97.18 ± 0.18

94.70 ± 0.41

12.5

Hexane Fraction

2.78 ± 2.73b

16.04 ± 4.78b

31.94 ± 5.17b

69.07 ± 2.51a

98.98 ± 1.22

96.52 ± 3.02

65.12

Diethyl ether Fraction

8.31 ± 0.87b

13.04 ± 2.80b

30.98 ± 4.21b

52.64 ± 6.11a

96.54 ± 0.92

95.65 ± 0.65

71.85

Ethyl acetate Fraction

14.60 ± 3.07bc

18.42 ± 2.65b

50.06 ± 0.36bc

84.45 ± 2.80a

98.55 ± 0.51

97.45 ± 1.08

50

n-Butanol Fraction

10.57 ± 0.21bc

14.93 ± 2.83b

26.07 ± 4.53bc

78.75 ± 4.63ab

98.35 ± 0.24

97.75 ± 0.43

61.175

  1. Values are mean ± S.E. of three parallel measurements
  2. Different letters indicate significant differences between same concentrations of Cornus capitata methanolic extract and its fractionates (p < 0.05, Tukeys HSD test, F-ratio- 49.935 (12.5 μg/mL), 55.279 (25 μg/mL), 46.702 (50 μg/mL), 16.690 (100 μg/mL), 1.861 (200 μg/mL), 0.683 (400 μg/mL)
  3. Cornus capitata methanolic extract (leaves) (4.25% at 1.5 μg/mL; 6% at 3.1 μg/mL and 19% inhibition at 6.25 μg/mL concentration)