Fig. 7

Effects of bioconverted mulberry leaf extract (BMLE) and unaltered mulberry leaf extract (MLE) on indices of insulin resistance and insulin sensitivity in obese diabetic mice. MLE (300 and 600 mg/kg) or BMLE (300 and 600 mg/kg) were administered (PO) for 7 weeks in obese diabetic mice, and (a) homeostasis model assessment of insulin resistance (HOMA-IR) and (b) quantitative insulin sensitivity check index (QUICKI) values were calculated by measuring fasting glucose and insulin levels. Data are expressed as the mean ± SEM (n = 7). * P < 0.05 and ** P < 0.01 versus the vehicle; ^# P < 0.05 versus the MLE-treated group (600 mg/kg). HFD, high-fat diet; NA, nicotinamide; STZ, streptozotocin