Fig. 6
Effect of bioconverted mulberry leaf extract (BMLE) and unaltered mulberry leaf extract (MLE) on HbA1C blood concentrations and plasma insulin levels in obese diabetic mice. MLE (300 and 600 mg/kg) or BMLE (300 and 600 mg/kg) were administered (PO) for 7 weeks in obese diabetic mice, and (a) the amount of glycated hemoglobin (HbA1C) in blood and (b) plasma insulin level was measured. Data are expressed as the mean ± SEM (n = 7). * P < 0.05 and ** P < 0.01 versus the vehicle; $ P < 0.05 versus the MLE-treated group (300 mg/kg); # P < 0.05 versus the MLE-treated group (600 mg/kg). HFD, high-fat diet; NA, nicotinamide; STZ, streptozotocin