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Fig. 4 | BMC Complementary and Alternative Medicine

Fig. 4

From: Effects of unaltered and bioconverted mulberry leaf extracts on cellular glucose uptake and antidiabetic action in animals

Fig. 4

Effects of bioconverted mulberry leaf extract (BMLE) compared to unaltered mulberry leaf extract (MLE) on the body weight and blood glucose levels of obese diabetic mice. Obese diabetic mice were produced by feeding on high-fat diet (HFD) for 8 weeks into six-week-old C57BL/6 mice and then (at the beginning of 9th week) injecting streptozotocin with nicotinamide (see Materials and methods). After checking for high blood glucose, mice were orally administered with MLE (300 and 600 mg/kg) or BMLE (300 and 600 mg/kg) for 7 weeks and the changes in (a) body weight and (b) blood glucose level were examined. Metformin (300 mg/kg) was used as a positive control. Data are expressed as the mean ± SEM (n = 7). ** P < 0.01 versus blood glucose levels in vehicle-control mice

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