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Fig. 3 | BMC Complementary and Alternative Medicine

Fig. 3

From: Multi-targeting chemoprevention of Chinese herb formula Yanghe Huayan decoction on experimentally induced mammary tumorigenesis

Fig. 3

YHHY Decoction inhibited tumor cell proliferation. a. Representative images of Ki-67 immunohistochemistry staining showing the proliferative cells in tumor sections in a: DMBA-induced rat and b: YHHY treated DMBA rat. Tumor sections were stained with primary Ki-67 antibody and the DAB Detection kit for cell proliferation detection. Ki-67-positive cells contain dark-brown nuclei. Scale bar: 50 μm. b. Quantitative analysis of the % of Ki-67 positive cells in the tumor sections. P < 0.05, student t test. n = 5 animals per group. c. Representative Western blot images of ERK1/2, PI3K and AKT in one tumor sample from each group. d. Expressions of ERK1/2, PI3K and AKT in 5 individual tumors in the YHHY Decoction treated vs. DMBA control group. e. Quantification of the western blot analysis for ERK1/2, PI3K and AKT in normal mammary glands (normal and YHHY groups) and mammary tumors (DMBA and YHHY+DMBA groups). * p < 0.05 vs. normal; ^ p < 0.05 vs. DMBA

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