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Table 3 Cytotoxic activity of the crude ethanolic extract and the isolated compounds against cancerous liver cells (HepG2 and KKU-M156) and normal cells (HaCaT)

From: Potential in vitro anti-allergic, anti-inflammatory and cytotoxic activities of ethanolic extract of Baliospermum montanum root, its major components and a validated HPLC method

Sample

IC50 (μg/mL) (Selective index)

HepG2

KKU-M156

HaCaT

Crude extract

0.06 ± 0.02* (> 100)

0.16 ± 0.02* (> 100)

> 100*

Compound1

87.07 ± 1.36* (> 1.15)

58.32 ± 5.95* (> 1.71)

> 100*

Compound2

47.61 ± 1.20* (> 2.10)

95.65 ± 0.48* (> 1.04)

> 100*

Compound3

90.33 ± 5.65* (> 1.11)

83.38 ± 5.20* (> 1.20)

> 100*

Vincristine

0.013 ± 0.0006 (< 0.008)

0.0030 ± 0.0015 (< 0.033)

< 0.0001

  1. Data performed as mean ± SD from triplicate experiments. Mean difference of IC50 data of tested sample and positive control were compared by Student’s t-test. *Significant difference at p-value < 0.05
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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