Fig. 7
From: Wu-Mei-wan protects pancreatic β cells by inhibiting NLRP3 Inflammasome activation in diabetic mice
Effect of WMW on the activation of the NLRP3 inflammasome in the mouse pancreas. Western blot analyses for NLRP3 (a); ASC (b); and caspase-1 (P20) (c). Band densities were converted to a bar graph. Immunofluorescence staining for NLRP3 (red) and caspase-1 (P20) (red) in pancreatic islets from wild-type, db/db, and db/db mice treated with HWMW (19,200 mg/kg/bw) are illustrated in (d) and (e), respectively. Nuclei were counterstained with DAPI (blue). Scales were 25 μm (d) and 50 μm (e). Signals for NLRP3 and caspase-1 (P20) were calculated in bar graph (f). P < 0.05 (*), P < 0.001 (***) (n = 6)