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Table 7 Observations of micronucleus and PCE: RBC ratio – summary

From: An oral toxicity test in rats and a genotoxicity study of extracts from the stems of Opuntia ficus-indica var. saboten

Dose (mg/kg/day)

Animals per Dose

MNPCE/2000 PCE

PCE:RBC Ratio

(% Control)

0

4

1.00 ± 0.82

0.52 ± 0.05

100

500

4

2.25 ± 1.26

0.58 ± 0.07

110

1000

4

1.50 ± 1.29

0.62 ± 0.04

119

2000

4

1.50 ± 1.00

0.55 ± 0.08

104

5000

4

1.00 ± 0.82

0.56 ± 0.08

106

CPA 70

4

78.25 ± 4.86*

0.52 ± 0.06

99

  1. OE: Opuntia ficus-indica var. saboten extract, MNPCE: Micronucleated polychromatic erythrocyte, PCE: Polychromatic erythrocyte, RBC: Red blood cells (polychromatic erythrocyte+normochromatic erythrocyte), CPA: Cyclophosphamide monohydrate (positive control article)
  2. The data are reported as the mean ± SD. The non-parametric Kruskal-Wallis test was performed on the frequency of micronucleus using SPSS Statistics 22 for Medical Science in the micronucleus test, and the negative and positive controls data were analyzed using the Mann-Whitney U test. *Significantly different from the negative control group at P < 0.05