Dose (mg/kg/day) | Animals per Dose | MNPCE/2000 PCE | PCE:RBC Ratio | (% Control) |
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0 | 4 | 1.00 ± 0.82 | 0.52 ± 0.05 | 100 |
500 | 4 | 2.25 ± 1.26 | 0.58 ± 0.07 | 110 |
1000 | 4 | 1.50 ± 1.29 | 0.62 ± 0.04 | 119 |
2000 | 4 | 1.50 ± 1.00 | 0.55 ± 0.08 | 104 |
5000 | 4 | 1.00 ± 0.82 | 0.56 ± 0.08 | 106 |
CPA 70 | 4 | 78.25 ± 4.86* | 0.52 ± 0.06 | 99 |
- OE: Opuntia ficus-indica var. saboten extract, MNPCE: Micronucleated polychromatic erythrocyte, PCE: Polychromatic erythrocyte, RBC: Red blood cells (polychromatic erythrocyte+normochromatic erythrocyte), CPA: Cyclophosphamide monohydrate (positive control article)
- The data are reported as the mean ± SD. The non-parametric Kruskal-Wallis test was performed on the frequency of micronucleus using SPSS Statistics 22 for Medical Science in the micronucleus test, and the negative and positive controls data were analyzed using the Mann-Whitney U test. *Significantly different from the negative control group at P < 0.05