An oral toxicity test in rats and a genotoxicity study of extracts from the stems of Opuntia ficus-indica var. saboten

Han, Eun Hye; Lim, Mi Kyung; Lee, Sang Ho; Rahman, Md. Mahbubur; Lim, Young-Hee

doi:10.1186/s12906-019-2442-7

BMC Complementary Medicine and Therapies

Table 1 Effect of oral administration of OE on body weight, food and water consumption, and relative organs weight to body weight

From: An oral toxicity test in rats and a genotoxicity study of extracts from the stems of Opuntia ficus-indica var. saboten

	Male				Female
	G1	G2	G3	G4	G1	G2	G3	G4
IBW (g)	200.81 ± 12.55	198.09 ± 7.90	201.98 ± 8.35	202.77 ± 12.53	144.92 ± 5.29	149.25 ± 6.00	153.67 ± 9.68	160.69 ± 6.01
FBW (g)	220.79 ± 15.32	211.72 ± 7.37	219.15 ± 10.37	217.26 ± 9.93	161.83 ± 2.88	166.26 ± 7.00	173.32 ± 12.22	173.29 ± 3.79
Food consumption g/day	20.91 ± 1.11	19.46 ± 1.20	20.14 ± 0.91	20.11 ± 0.79	12.95 ± 1.32	14.61 ± 1.01	15.39 ± 0.31	15.10 ± 0.05
Water consumption mL/day	22.83 ± 1.13	24.14 ± 0.82	24.42 ± 0.35	25.27 ± 0.08	22.10 ± 0.93	17.26 ± 1.42	20.95 ± 0.35	22.03 ± 0.73
Adrenal gland-left	0.0193 ± 0.003	0.0174 ± 0.001	0.0214 ± 0.002	0.0195 ± 0.004	0.0212 ± 0.003	0.0224 ± 0.002	0.0247 ± 0.004	0.0217 ± 0.002
% to BW	0.009 ± 0.001	0.008 ± 0.001	0.010 ± 0.001	0.009 ± 0.002	0.015 ± 0.001	0.015 ± 0.001	0.016 ± 0.002	0.014 ± 0.001
Adrenal gland-right	0.017 ± 0.002	0.018 ± 0.001	0.021 ± 0.003	0.019 ± 0.003	0.021 ± 0.004	0.021 ± 0.002	0.024 ± 0.005	0.022 ± 0.002
% to BW	0.008 ± 0.001	0.008 ± 0.000	0.009 ± 0.001	0.009 ± 0.002	0.015 ± 0.002	0.014 ± 0.001	0.015 ± 0.003	0.014 ± 0.001
Thymus	0.631 ± 0.076	0.572 ± 0.168	0.694 ± 0.105	0.614 ± 0.057	0.368 ± 0.046	0.438 ± 0.043	0.385 ± 0.041	0.441 ± 0.052
% to BW	0.285 ± 0.016	0.271 ± 0.080	0.316 ± 0.040	0.283 ± 0.023	0.255 ± 0.042	0.293 ± 0.019	0.250 ± 0.015	0.276 ± 0.043
Spleen	0.697 ± 0.058	0.574 ± 0.091	0.653 ± 0.045	0.616 ± 0.028	0.434 ± 0.078	0.411 ± 0.023	0.423 ± 0.072	0.467 ± 0.032
% to BW	0.316 ± 0.007	0.272 ± 0.050	0.298 ± 0.008	0.284 ± 0.024	0.299 ± 0.046	0.276 ± 0.021	0.275 ± 0.041	0.290 ± 0.009
Kidney-left	0.877 ± 0.079	0.797 ± 0.044	0.851 ± 0.034	0.895 ± 0.011	0.624 ± 0.085	0.596 ± 0.025	0.619 ± 0.058	0.653 ± 0.083
% to BW	0.397 ± 0.008	0.377 ± 0.031	0.388 ± 0.007	0.412 ± 0.014	0.430 ± 0.051	0.399 ± 0.017	0.403 ± 0.026	0.406 ± 0.043
Kidney-right	0.889 ± 0.056	0.818 ± 0.064	0.876 ± 0.012	0.897 ± 0.010	0.637 ± 0.069	0.588 ± 0.008	0.608 ± 0.062	0.667 ± 0.057
% to BW	0.403 ± 0.010	0.387 ± 0.037	0.400 ± 0.017	0.414 ± 0.022	0.440 ± 0.044	0.395 ± 0.021	0.396 ± 0.029	0.415 ± 0.026
Heart	0.945 ± 0.161	0.782 ± 0.042	0.868 ± 0.047	0.905 ± 0.069	0.620 ± 0.015	0.620 ± 0.024	0.626 ± 0.066	0.620 ± 0.068
% to BW	0.426 ± 0.046	0.370 ± 0.033	0.396 ± 0.008	0.416 ± 0.020	0.428 ± 0.023	0.415 ± 0.002	0.409 ± 0.048	0.386 ± 0.038
Lung	1.243 ± 0.111	1.048 ± 0.081	1.138 ± 0.079	1.159 ± 0.082	0.912 ± 0.042	0.882 ± 0.104	0.950 ± 0.105	1.031 ± 0.110
% to BW	0.562 ± 0.012	0.495 ± 0.043	0.519 ± 0.034	0.534 ± 0.043	0.629 ± 0.018	0.590 ± 0.052	0.620 ± 0.076	0.641 ± 0.058
Brain	1.918 ± 0.027	1.825 ± 0.049	1.858 ± 0.108	1.904 ± 0.027	1.741 ± 0.044	1.825 ± 0.084	1.788 ± 0.065	1.750 ± 0.113
% to BW	0.871 ± 0.049	0.863 ± 0.047	0.849 ± 0.047	0.877 ± 0.029	1.202 ± 0.043	1.223 ± 0.008	1.168 ± 0.111	1.090 ± 0.083
Liver	7.564 ± 1.085	6.768 ± 0.356	7.725 ± 0.576	7.464 ± 0.520	4.915 ± 0.143	4.815 ± 0.518	4.830 ± 0.213	5.158 ± 0.200
% to BW	3.417 ± 0.259	3.196 ± 0.097	3.531 ± 0.334	3.439 ± 0.257	3.393 ± 0.073	3.223 ± 0.253	3.147 ± 0.119	3.211 ± 0.082

G1: negative control; G2: 500 mg/kg OE treated group; G3: 1000 mg/kg OE treated group; G4: 2000 mg/kg OE treated group. IBW: initial body weight; FBW: final body weight
Data are expressed as mean ± SD. Bonferroni’s post hoc test was used following a one-way ANOVA vs. G1, and the homogeneity of variance was tested using Levene’s test. There was no significance difference among all the groups

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