Table 5 HepG2 Cytotoxicity, Streptomyces hyphae formation inhibition and Anti-leishmanial capability of various solvent extracts
From: Bio-guided profiling and HPLC-DAD finger printing of Atriplex lasiantha Boiss
Extract/ Samples | Hep G2 Cytotoxicity | Protein kinase inhibition | Antileishmanial capability | |||
|---|---|---|---|---|---|---|
inhibition% | IC50 (μg/ml) | Diameter of zone of inhibition (mm) | Mortality % | LC50 μg/ml | ||
| Â | Â | Clear zone | Bald zone | Â | Â | |
N | – | – | – | 7 ± 0.37*** | 71 ± 0.49 | 12.8*** |
C | 10 ± 1.5 | 204*** | – | 8 ± 0.81*** | – | – |
EA | 18 ± 1.01 | 101*** | – | 9 ± 0.49*** | – | – |
A | 3 ± 0.9 | 773*** | – | 7 ± 0.97*** | – | – |
E | 7 ± 0.89 | 312*** | – | 8 ± 0.43*** | – | – |
M | 21 ± 0.37 | 096*** | – | 9 ± 0.57*** | – | – |
W | – | – | – | – | 71 ± 0.93 | 16.8*** |
NEA | – | – | – | 8 ± 0.68*** | 72 ± 0.76 | 11.5** |
EN | 16 ± 1.34 | 168*** | 8 ± 0.34 | – | – | – |
MEC | 39 ± 1.01 | 046*** | 9 ± 0.41 | – | – | – |
MEEA | – | – | 8 ± 0.70 | – | – | – |
MEA | 12 ± 0.57 | 191*** | – | 11 ± 0.49*** | – | – |
AW | 15 ± 0.83 | 149*** | 9 ± 0.51 | – | – | – |
MD | – | – | 8 ± 0.68 | – | – | – |
PC | 57 ± 2.56 | 5.10 | – | 21 ± 1.02 | 79 ± 1.15 | 0.01 |