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Table 5 HepG2 Cytotoxicity, Streptomyces hyphae formation inhibition and Anti-leishmanial capability of various solvent extracts

From: Bio-guided profiling and HPLC-DAD finger printing of Atriplex lasiantha Boiss

Extract/ Samples Hep G2 Cytotoxicity Protein kinase inhibition Antileishmanial capability
inhibition% IC50 (μg/ml) Diameter of zone of inhibition (mm) Mortality % LC50 μg/ml
   Clear zone Bald zone   
N 7 ± 0.37*** 71 ± 0.49 12.8***
C 10 ± 1.5 204*** 8 ± 0.81***
EA 18 ± 1.01 101*** 9 ± 0.49***
A 3 ± 0.9 773*** 7 ± 0.97***
E 7 ± 0.89 312*** 8 ± 0.43***
M 21 ± 0.37 096*** 9 ± 0.57***
W 71 ± 0.93 16.8***
NEA 8 ± 0.68*** 72 ± 0.76 11.5**
EN 16 ± 1.34 168*** 8 ± 0.34
MEC 39 ± 1.01 046*** 9 ± 0.41
MEEA 8 ± 0.70
MEA 12 ± 0.57 191*** 11 ± 0.49***
AW 15 ± 0.83 149*** 9 ± 0.51
MD 8 ± 0.68
PC 57 ± 2.56 5.10 21 ± 1.02 79 ± 1.15 0.01
  1. Results were presented as mean ± SD; n = 3; The percent potential of each sample has been expressed at 100 μg/mL **: P < 0.01, ***: P < 0.001. -- = Not active, N: n-hexane, C: Chloroform, EA: Ethyl acetate, A: Acetone, E: Ethanol, M: Methanol, W: Distilled water, NEA: n-hexane-Ethyl acetate, EN: ethanol-n-hexane, MEC: methanol-chloroform MEEA: Methanol-Ethyl acetate, MEA: methanol-acetone, AW: acetone-water, MD: methanol-water, PC: Positive control; Doxorubicin employed in cytotoxicity assay, Surfactin in Protein kinase inhibition assay, Amphotericin-B in Antileshmanial assay