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Fig. 4 | BMC Complementary and Alternative Medicine

Fig. 4

From: Protective effects of Danshen injection against erectile dysfunction via suppression of endoplasmic reticulum stress activation in a streptozotocin-induced diabetic rat model

Fig. 4

Danshen injection suppressed ER stress via downregulation of Grp78 and CHOP in corpus cavernous tissue. a Immunohistochemical analysis of Grp78 expression in penile tissue sections: (i) Control group; (ii) Diabetes group; (iii) Danshen injection (0.5 mL/kg) group; (iv) Danshen injection (1 mL/kg) group. b Data represent the means ± S.E.M. for five rats per group. Scale bar: 20 μm. c Immunohistochemical analysis of CHOP expression: (i) Control group; (ii) Diabetes group. (iii) Danshen treatment (0.5 mL/kg) group; (iv) Danshen treatment (1 mL/kg) group. d Data represent the means ± S.E.M. for five rats per group. Scale bar: 50 μm. e Western blot analysis of Grp78 and CHOP expression in penile tissue and (f) densitometry of the respective blots. Data are represented as the means ± S.E.M. for five rats per group, normalized to β-actin and expressed as a percentage of the control. g, h The mRNA levels of Grp78 and CHOP among the four groups (n = 5)

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