Fig. 5

Expression of the proteins that are involved in the mTOR signaling pathways. The HepG2/mTOR⁺ cells were treated with 0.1%DMSO as solvent control, or 2 mg/L DDP, or different concentrations of COE (20, 40, and 80 mg/L) for 24 h. The proteins expression of mTOR, p-mTOR, 4E-BP1, p-4E-BP1, P70S6K, and p-P70S6K were studied by Western blot analysis. (**P < 0.01, ***P < 0.001, compared with the vehicle control)