Fig. 1
The AG129 mice infected with non-adapted serotype 2 NGC strain dengue virus developed NS1 antigenemia and splenomegaly. AG129 mice intraperitoneally infected with 2 X 103 PFU or 2 X 104 PFU or 2 X 105 PFU of dengue virus strain NGC on Day 0 post infection. The mock infected mice group (n=5) were inoculated with 200 μl of media only. a The plasma NS1 level of mock infected (black circle) (n=5) and infected (n=5) (blue square: 2 X 103 PFU; yellow triangle: 2 X 104 PFU; red triangle: 2 X 105 PFU) AG129 mice groups were detected on day 1, 3, 5, 7 and 9 post infection by NS1 antigen immunoassay. Data represent mean values ± standard error of the mean (SEM). b The spleens of mock infected (n=5) and infected (n=5) AG129 mice groups were harvested and weighed on Day 11 post infection. Data represent mean values ± standard deviations (SD). The data comparison was done by using Tukey’s multiple comparison ANOVA. Statistical significance (p<0.05) is depicted with asterisks above the columns