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Table 6 Effect of E. umbellata fruit extract/fractions on liver and renal functions in streptozotocin-induced diabetic rats

From: Phytochemical analysis and antidiabetic potential of Elaeagnus umbellata (Thunb.) in streptozotocin-induced diabetic rats: pharmacological and computational approach

S.No Treatment groups Dose (mg/kg) SGPT (IU) SGOT (IU) ALP (IU) BUN (mg/dl) Serum creatinine (mg/ml)
1 aNormal control 0.3 ml 20 ± 5.6*** 16 ± 3.5*** 141 ± 7.2** 18.5 ± 3.5** 0.527 ± 0.2***
2 bDiabetic control 0.3 ml 62.47 ± 7.5 62.27 ± 6.1 272.57 ± 8.3 35.7 ± 4.5 2.57 ± 0.2
3 cGlibenclamide 0.5 24.5 ± 6.4*** 20.07 ± 3.6*** 142.47 ± 9.3*** 17.6 ± 2.3** 0.56 ± 0.2***
4 cMe-Ext 100 44.56 ± 6.0* 39.17 ± 3.9** 197.39 ± 10.33* 21.4 ± 5.4** 1.50 ± 0.3*
5 cMe-Ext 200 30.37 ± 8.0** 21.97 ± 5.6*** 160.19 ± 12.23** 20.3 ± 3.2** 0.85 ± 0.2**
6 cChf-Ext 100 45.70 ± 4.5** 34.37 ± 3.5** 174.22 ± 8.5* 24.6 ± 4.5* 1.46 ± 0.2*
7 cChf-Ext 200 28.80 ± 3.5* 22.37 ± 4.5** 154.32 ± 11.5** 18.6 ± 2.5** 0.76 ± 0.2**
8 cEtAC-Ext 100 38.70 ± 4.5* 45.37 ± 2.8* 185.50 ± 17.2* 25.5 ± 5.2* 1.7 ± 0.3*
9 cEtAC-Ext 200 28.85 ± 3.5** 25.37 ± 3.5** 165.50 ± 11.2** 21.5 ± 6.2** 1.2 ± 0.2*
  1. Each value is mean ± SEM of 8 animals; comparisons were made between anormal control to bdiabetic control using student t-test (** p < 0.01, ***p < 0.001) and between bdiabetic control to positive control c(Glibenclamide/extract) treated groups using one way ANOVA followed by Dunnett’s posthoc multiple comparison test ((* p < 0.05, ** p < 0.01, ***p < 0.001)