Phytochemical analysis and antidiabetic potential of Elaeagnus umbellata (Thunb.) in streptozotocin-induced diabetic rats: pharmacological and computational approach

Table 6 Effect of E. umbellata fruit extract/fractions on liver and renal functions in streptozotocin-induced diabetic rats

S.No	Treatment groups	Dose (mg/kg)	SGPT (IU)	SGOT (IU)	ALP (IU)	BUN (mg/dl)	Serum creatinine (mg/ml)
1	^aNormal control	0.3 ml	20 ± 5.6***	16 ± 3.5***	141 ± 7.2**	18.5 ± 3.5**	0.527 ± 0.2***
2	^bDiabetic control	0.3 ml	62.47 ± 7.5	62.27 ± 6.1	272.57 ± 8.3	35.7 ± 4.5	2.57 ± 0.2
3	^cGlibenclamide	0.5	24.5 ± 6.4***	20.07 ± 3.6***	142.47 ± 9.3***	17.6 ± 2.3**	0.56 ± 0.2***
4	^cMe-Ext	100	44.56 ± 6.0*	39.17 ± 3.9**	197.39 ± 10.33*	21.4 ± 5.4**	1.50 ± 0.3*
5	^cMe-Ext	200	30.37 ± 8.0**	21.97 ± 5.6***	160.19 ± 12.23**	20.3 ± 3.2**	0.85 ± 0.2**
6	^cChf-Ext	100	45.70 ± 4.5**	34.37 ± 3.5**	174.22 ± 8.5*	24.6 ± 4.5*	1.46 ± 0.2*
7	^cChf-Ext	200	28.80 ± 3.5*	22.37 ± 4.5**	154.32 ± 11.5**	18.6 ± 2.5**	0.76 ± 0.2**
8	^cEtAC-Ext	100	38.70 ± 4.5*	45.37 ± 2.8*	185.50 ± 17.2*	25.5 ± 5.2*	1.7 ± 0.3*
9	^cEtAC-Ext	200	28.85 ± 3.5**	25.37 ± 3.5**	165.50 ± 11.2**	21.5 ± 6.2**	1.2 ± 0.2*

Each value is mean ± SEM of 8 animals; comparisons were made between ^anormal control to ^bdiabetic control using student t-test (** p < 0.01, ***p < 0.001) and between ^bdiabetic control to positive control ^c(Glibenclamide/extract) treated groups using one way ANOVA followed by Dunnett’s posthoc multiple comparison test ((* p < 0.05, ** p < 0.01, ***p < 0.001)

ISSN: 2662-7671